2013
DOI: 10.1371/journal.pone.0053616
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A Novel Approach to Enhancing Ganoderic Acid Production by Ganoderma lucidum Using Apoptosis Induction

Abstract: Ganoderma lucidum is one of most widely used herbal medicine and functional food in Asia, and ganoderic acids (GAs) are its active ingredients. Regulation of GA biosynthesis and enhancing GA production are critical to using G. lucidum as a medicine. However, regulation of GA biosynthesis by various signaling remains poorly understood. This study investigated the role of apoptosis signaling on GA biosynthesis and presented a novel approach, namely apoptosis induction, to increasing GA production. Aspirin was ab… Show more

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Cited by 62 publications
(45 citation statements)
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“…Recently, it was reported that the MAPK cascade played an important role in regulating sterigmatocystin biosynthesis [43]. In G. lucidum , H 2 O 2 induced phosphorylation of the proteins Hog-1 and Fus3, which are homologs of the mammalian MAPKs p38 and ERK [49]. In contrast, the mammalian JNK homolog in BCRC 36111 was not detected using a JNK-specific antibody [50].…”
Section: Discussionmentioning
confidence: 99%
“…Recently, it was reported that the MAPK cascade played an important role in regulating sterigmatocystin biosynthesis [43]. In G. lucidum , H 2 O 2 induced phosphorylation of the proteins Hog-1 and Fus3, which are homologs of the mammalian MAPKs p38 and ERK [49]. In contrast, the mammalian JNK homolog in BCRC 36111 was not detected using a JNK-specific antibody [50].…”
Section: Discussionmentioning
confidence: 99%
“…You et al . reported that the addition of aspirin significantly increased GA biosynthesis, which is accompanied by a burst of intracellular ROS (You et al ., ). Endogenous ROS also exhibits similar effects on the regulation of growth and GA biosynthesis in G. lucidum .…”
Section: Introductionmentioning
confidence: 97%
“…You et al found that the addition of H 2 O 2 is an efficient way to enhance the accumulation of GAs in G. lucidum (You et al, 2012). You et al reported that the addition of aspirin significantly increased GA biosynthesis, which is accompanied by a burst of intracellular ROS (You et al, 2013). Endogenous ROS also exhibits similar effects on the regulation of growth and GA biosynthesis in G. lucidum.…”
Section: Introductionmentioning
confidence: 99%
“…Although the specific functions of GPx in G. lucidum have not been reported, existing studies in other species have revealed a close relationship between GPx and ROS. In previous studies, the addition of exogenous H 2 O 2 , salicylic acid, phenobarbital, and other compounds affect ROS levels and induce physiological effects, such as apoptosis and the induction of secondary mechanisms, in G. lucidum (Liang et al, 2010;You et al, 2013;Zhang et al, 2010). Thus, although many studies have indicated that both stress and the addition of exogenous ROS generate ROS-related changes, the cellular mechanisms underlying these changes are still not well understood.…”
Section: Introductionmentioning
confidence: 99%