A novel approach to preparing magnetic protein microspheres with core-shell structure

Jiang, Wei; Sun, Zhen‐Dong; Li, Fengsheng; Chen, Kai; Liu, Tianyu; Liu, Jialing; Zhou, Ting; Guo, Rui

doi:10.1016/j.jmmm.2010.09.039

Cited by 15 publications

(8 citation statements)

References 21 publications

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“…Nowadays active research is focused on the preparation of nanoparticles using proteins like albumin, gelatin, gliadin and legumin for drug delivery in chemotherapeutic applications [18,19].…”

Section: Introductionmentioning

confidence: 99%

Magnetic nanoparticles–serum proteins bioconjugates for binding of irinotecan

Tamyurek

Maltaş

Baş

et al. 2015

International Journal of Biological Macromolecules

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Section: Introductionmentioning

confidence: 99%

Magnetic nanoparticles–serum proteins bioconjugates for binding of irinotecan

Tamyurek

Maltaş

Baş

et al. 2015

International Journal of Biological Macromolecules

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“…In these experiments, researchers usually pay more attention to toxicity effect of drug delivering, releasing process on the cell or tissue in lesion, and biocompatibility of drug carriers. Today there are more researches on polyethylene glycol (PEG), polylactic acid (PLA), and/or poly-caprolactone (PCL) for coating nanoparticles in the internal and external environment [8][9][10][11][12][13][14][15][16]. The toxicity reduction in human fibroblast cell was reported with superparamagnetic particles coated with pullulan in human skin fibroblast [17].…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility and Toxicity of Polylactic Acid/Ferrosoferric Oxide Nanomagnetic Microsphere

Xiang

et al. 2017

Journal of Nanomaterials

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Magnetic targeted drugs delivery system (MTDDS) is a new targeted drug system, which can greatly reduce the dosage and improve the therapeutic efficiency of medicine. Currently superparamagnetic ferric oxide plays important function as targeted drug in the treatment of tumors, but cytotoxicity was still regarded as side effect in the process of drug. In this paper, we take advantage of drug carrier (ferric oxide) toxicity controlling cancer cell growth in cancer treatment, increasing targeted drug efficiency. We applied the modified chemical precipitation method to prepare polylactic acid (PLA) coated high-purity superparamagnetic Fe 3 O 4 nanoparticles for targeted drug, characterized PLA/Fe 3 O 4 microspheres physical and chemical properties, and then investigated cytotoxicity influence of PLA/Fe 3 O 4 nanomagnetic microspheres as carrier for normal liver cells (7701) and liver cancer cells (HePG2) in different concentration; results of MTT and hemolysis and micronucleus test showed that carrier restrained the growth of HePG2 in special concentration, meanwhile the proliferation rate of liver cells was not affected. The study demonstrates that compared with liver cell, liver cancer cells (HepG2) are easy to be disturbed by PLA/Fe 3 O 4 nanomagnetic microsphere, which have higher sensitivity and absorption ability. We hope to take advantage of the susceptible property of cancer cells for carriers to improve targeted drug function.

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“…To date, many methods of preparation have been developed for magnetic polymer microspheres, for example, dispersion polymerization [14][15][16], precipitation polymerization [17], emulsion polymerization [18][19][20], inverse emulsion polymerization [21], inverse microemulsion polymerization [22], seeded polymerization [23,24], soap-free emulsion polymerization [25,26], atom transfer radical polymerization (ATRP) [27], and so on [28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%