A novel approach to study the pMDI plume using an infrared camera and to evaluate the aerodynamic properties after varying the time between actuations

Kunda, Nitesh K.; Hautmann, Julia; Godoy, Sebastián; Marshik, Patricia; Chand, Ramesh; Krishna, S.; Muttil, Pavan

doi:10.1016/j.ijpharm.2017.04.051

Cited by 6 publications

(4 citation statements)

References 22 publications

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“…Shaking the MDI vigorously before inhalation is a fundamental step for achieving a consistent steady drug dose [ 42 , 43 ]. We noted that most children in both the verbal counseling and the advanced counseling groups totally neglected to do this, or they shake inadequately in the first counseling visit but after three successive visits, the number of mistakes in this inhalation step decreased by 74% in the verbal counseling group while it decreased in advanced counseling group by 90.7%…”

Section: Discussionmentioning

confidence: 99%

The Effect of Adding a Training Device and Smartphone Application to Traditional Verbal Counseling in Asthmatic Children

et al. 2021

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Introduction: New training devices have been introduced to help in inhaler counseling by addressing the inspiratory flow through the metered-dose inhaler (MDI), which is the most important problem of the MDI inhalation technique. This study aims to compare the effects of MDI traditional verbal counseling and advanced counseling using training devices with a smartphone application in pediatric asthmatic patients.

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Section: Discussionmentioning

confidence: 99%

The Effect of Adding a Training Device and Smartphone Application to Traditional Verbal Counseling in Asthmatic Children

et al. 2021

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“…The IP deposition was found to correlate with the flow rate when actuating the pMDI, and the most pronounced deviation was found when low volume flow rates were applied. As pMDIs utilize energy provided by flash evaporation of a liquefied propellant (i.e., aerosol generation is independent from the patients inspiratory air flow), the timeframe for generating the aerosol plume is less than half of a second, 43 so modulation of the air flow over the entire duration of the experiment might not be as relevant as it is for dry powder devices, where the energy required for deagglomeration is provided by the inspiratory air flow of the patients. Also, patients in the lung deposition studies were trained on how to use the device (excluding forceful and weak inhalation) so this method was not incorporated into the setup of the current study.…”

Section: Discussionmentioning

confidence: 99%

Cascade Impactor Performance of Commercial pMDI Formulations Using Modified Induction Ports

et al. 2020

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The induction port (IP) for aerosol analysis with the Next Generation Pharmaceutical Impactor as monographed in the United States and European pharmacopoeia (USPIP) lacks physiological relevance, which, amongst other reasons, has been identified as critical for the predictability of in vitro aerosol data to lung deposition observed in vivo. In this publication, we report the impact of replacing the USPIP with two modified induction ports, which were designed based around geometries derived from a computer tomographic scan of a human trachea and the distal section of the USPIP. Test formulations were selected on the basis of availability of in vivo lung deposition data so that results obtained in vitro could be evaluated for their predictability. All formulations assessed showed increased deposition in the modified induction ports, and different mechanisms of particle deposition have been identified. In vitro predictions of the lung deposition were found to correlate well with the in vivo observations reported using the modified induction ports. Furthermore, the quality of the correlation was found superior to the one achieved with the USPIP with an average deviation of the predicted from observed values (n = 10) of 6 ± 4, 12 ± 6, and 16 ± 6% for the modified induction ports (mIP and mIPext) and the USPIP, respectively, when using a fine particle fraction (FPF) cutoff value of 5 μm. Using a FPF cutoff value of 3 μm yielded a more accurate in vitro−in vivo correlation with an average deviation of the predicted from observed values of 5 ± 4, 7 ± 5, and 8 ± 4% for the mIP, mIPext, and USPIP, respectively. For both FPF size cutoff values, the mIP yielded the most accurate in vitro−in vivo correlation.

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“…These add-on devices increase the time between device actuation and inhalation allowing patients to inhale drug over longer periods of time thereby enhancing drug delivery to the deep lungs and decreasing deposition in the oropharyngeal regions and upper airways Kunda et al, 2017). More recently, pMDIs have been designed to operate on breath-activation rather than hand-breath coordination (Newman, 2005;Zhou et al, 2014).…”

Section: Problems Associated With Different Inhaler Devicesmentioning

confidence: 99%

Challenges Associated with the Pulmonary Delivery of Therapeutic Dry Powders for Preclinical Testing

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Kunda

Muttil

2019

KONA

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Significant progress has been made over the last half-century in delivering therapeutics by the pulmonary route. Inhaled therapeutics are administered to humans using metered-dose inhalers, nebulizers, or dry powder inhalers, and each device requires a different formulation strategy for the therapeutic to be successfully delivered into the lung. In recent years, there has been a shift to the use of dry powder inhalers due to advantages in the consistency of the dose delivered, ease of administration, and formulation stability. Numerous preclinical studies, involving small and large animals, have evaluated dry powder drugs, vaccines, and immunotherapeutics delivered by the pulmonary route. These studies used different dry powder delivery devices including nose-only, whole-body, and intratracheal administration systems, each of which works with different aerosolization mechanisms. Unfortunately, these delivery platforms usually lead to variable powder deposition in the respiratory tract of animals. In this review, we will discuss obstacles and variables that affect successful pulmonary delivery and uniform powder deposition in the respiratory tract, such as the type of delivery device, dry powder formulation, and the animal model used. We will conclude by outlining factors that enhance the reproducible deposition of dry powders in the respiratory tract of preclinical animal models and identifying knowledge and technology gaps within the field. We will also outline the important factors necessary for successful translation of studies performed in preclinical models to humans.

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A novel approach to study the pMDI plume using an infrared camera and to evaluate the aerodynamic properties after varying the time between actuations

Cited by 6 publications

References 22 publications

The Effect of Adding a Training Device and Smartphone Application to Traditional Verbal Counseling in Asthmatic Children

The Effect of Adding a Training Device and Smartphone Application to Traditional Verbal Counseling in Asthmatic Children

Cascade Impactor Performance of Commercial pMDI Formulations Using Modified Induction Ports

Challenges Associated with the Pulmonary Delivery of Therapeutic Dry Powders for Preclinical Testing

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