A Novel Aspect for Depression and Cytokine Hypothesis: \NLRP3 Inflammasome\

Şahin, Ceren; Arıcıoğlu, Feyza

doi:10.5455/musbed.20130628030312

Cited by 3 publications

(5 citation statements)

References 18 publications

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“…Studies show that NLRP3 inflammasome plays an important role in various diseases, including Alzheimer's disease, diabetes and atherosclerosis [10,11]. Recent researches implicate that NLRP3 inflammasome and related pathways are associated with the pathogenesis of depression, and it could be accepted as an intriguing subject for possibly bringing a new approach for antidepressant therapies [12,13].…”

Section: Introductionmentioning

confidence: 99%

Geraniol produces antidepressant-like effects in a chronic unpredictable mild stress mice model

Deng

Xue

et al. 2015

Physiology & Behavior

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Section: Introductionmentioning

confidence: 99%

Geraniol produces antidepressant-like effects in a chronic unpredictable mild stress mice model

Deng

Xue

et al. 2015

Physiology & Behavior

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“…En çok çalışılmış ve en iyi karakterize edilmiş inflamazom sensör molekülü olan NLRP3, NLR ailesinin üçlü bir proteinidir ve bir amino terminal PİRİN (PYD) alanı, bir nükleotid bağlayıcı NACHT alanı ve bir karboksi terminal lösin açısından zengin tekrar (LRR) alanı içerir. NLRP3 inflamazomu, makrofaj ve mikroglia gibi immün sistem hücrelerine ulaşan tehlike sinyallerini tanıyan ve IL-1β ile IL-18 aracılı enflamatuvar yanıtların aktivasyonuna aracılık eden sitozolik sinyal kompleksidir 8,9 . NLRP3 inflamazomu, bakteriyel, fungal ve viral enfeksiyonlara karşı konakçı immün savunması için de oldukça önemlidir 3 .…”

Section: Nlrp3 İnflamazomunclassified

“…NLRP3 aktivasyonu birçok hücre içi mekanizma ile düzenlenmektedir. Bunlar arasında; ATP, lizozomal hasar, mitokondriyal disfonksiyon, ROS (Reaktif oksijen türleri) aracılı aktivasyon, hücre membranına hasar veren mikrobiyal toksinler ve fagosite edilen çözünmez kristaller yer almaktadır 3,9 . İkinci sinyalizasyon, inaktif NLRP3'ün aktivasyonuna ve aktif NLRP3, ASC ve pro-kaspaz-1'in bir kompleks halinde birleşmesine yol açar.…”

Section: Nlrp3 Inflamazom Aktivasyonuunclassified

“…İlk sinyal sonucu, IL-6, TNF-α gibi proenflamatuvar sitokinlerin gen transkripsiyonları artar ve doğrudan salınımları gerçekleşir. Diğer taraftan, IL-1β ve IL-18 üretimi inflamazom aktivasyonunu gerektiren iki aşamalı bir süreçtir 9 . NF-κB, dinlenme koşulları altında, inflamazom aktivasyonunu başlatmak için yetersiz konsantrasyonlarda var olduğu düşünülen NLRP3 ekspresyonunu ile dinlenme halindeki hücrelerde eksprese edilmeyen pro-IL-1β ve pro-IL-18'in ekspresyonlarını upregüle etmektedir 13 .…”

Section: Nlrp3 Inflamazom İlk (Primer) Sinyalizasyon (Sinyal 1)unclassified

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NLRP3 İnflamazom Aktivasyon ve Düzenleme Mekanizmalarına Genel Bir Bakış

Şaker

Polat

2022

Arşiv Kaynak Tarama Dergisi

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The innate immune system is vital in host defense against pathogens entering the body. The NLRP3 (NACHT-, LRRand Pyrin Domain Containing 3) inflammasome, a component of the innate immune system, is a multimeric protein complex. Inflammasome activation is a process that starts and improves differently from classical inflammatory responses. In order to induce inflammasome activation, there must be a danger signal such as DAMP (Damage-Associated Molecular Pattern) or PAMP (Pathogen-Associated Molecular Pattern) detected. In response to these stimuli, caspase-1 is activated. This in turn leads to cleavage and maturation of potent pro-inflammatory cytokines, IL-1β (interleukin-1β) and IL-18 (interleukin-18) by mature caspase-1. Thus, inflammatory responses mediated by IL-1β and IL-18 are activated. Although NLPR3 activation is an important immune response, its overactivation can cause inflammatory disorders and cell death. For this reason, regulation and inhibition of the NLRP3 inflammasome may be a promising treatment approach for these autoinflammatory diseases. In this review presents the current understanding of the mechanisms of NLRP3 inflammasome activation, as well as recent advances in the non-canonical and alternative inflammasome pathways.

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“…Therefore, accelerating the process is important to enable athletes to perform more effectively in both training load and competitive performance. Many methods have been used, such as cold-water therapy (cryotherapy), hot water therapy, nutrition, ergogenic support, jogging, massage, and relaxation exercises (Smith et al, 1994;Alga y et al, 2007;Şahin, 2018).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Heart Rate Variability Biofeedback on Recovery After Aerobic Exercise

YILMAZ,

AKTOP,

ABDİOĞLU

et al. 2024

Preprint

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Recovery is a critical factor in athletic performance, and accelerating this process is essential to enable athletes to perform more effectively in both training load and competitive performance. After exercise, immediate recovery is potentially helpful for investigating autonomic activity levels, as they are definable with heart rate variability (HRV). The purpose of this study was to examine the effect of ten sessions of HRV-Biofeedback (HRV-BF) training on recovery process parameters after the aerobic performance. In this study, twenty-four soccer players aged 18–24 volunteered to participate. The athletes who met the research criteria were divided into an experimental group (n = 12) and a control group (n = 12). Each participant’s height, weight, BMI, body fat percentage, and aerobic capacity were measured before and after the 10-session intervention. The experimental group participated in a 10-session HRV-BF training and soccer training program, while the control group only participated in a 10-session soccer training program. Aerobic capacity tests were then applied again to experimental and control group participants. The effect of biofeedback on the three HRV parameters during the 5-minute acute recovery period after the test was investigated. The results showed that regularly applied HRV-BF training can significantly shorten the HRV recovery parameter after exercise. Specifically, the athletes who performed HRV-BF training demonstrated faster cardiovascular recovery after aerobic exercise. This suggests that implementing HRV-BF training for athletes can significantly accelerate their recovery processes during and after competitions. Given recent technological advancements, it is promising to consider adding HRV-BF training to stress management interventions, particularly in relation to physiological stress indicators.

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A Novel Aspect for Depression and Cytokine Hypothesis: \NLRP3 Inflammasome\

Cited by 3 publications

References 18 publications

Geraniol produces antidepressant-like effects in a chronic unpredictable mild stress mice model

Geraniol produces antidepressant-like effects in a chronic unpredictable mild stress mice model

NLRP3 İnflamazom Aktivasyon ve Düzenleme Mekanizmalarına Genel Bir Bakış

The Effect of Heart Rate Variability Biofeedback on Recovery After Aerobic Exercise

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