A Novel Avian Hypothalamic Peptide Inhibiting Gonadotropin Release

Tsutsui, Kazuyoshi; Saigoh, Etsuko; Ukena, Kazuyoshi; Teranishi, Hitoshi; Fujisawa, Yuko; Kikuchi, Motoshi; Ishii, Susumu; Sharp, P. J.

doi:10.1006/bbrc.2000.3350

Cited by 749 publications

(860 citation statements)

References 29 publications

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“…Since its discovery, the inhibitory action of GnIH on pituitary release of gonadotropins has been firmly established in birds and mammals (Tsutsui et al, 2000Osugi et al, 2004;Bentley et al, in press;Ciccone et al, 2004). Despite the focus of attention upon regulation of the release of gonadotropins, the distribution of GnIH-ir fibers in the central nervous system of birds and mammals has been suggestive of more than one function of this RF-amide peptide (Tsutsui et al, 2000;Ukena and Tsutsui, 2001;Bentley et al, 2003, in press;Ukena et al, 2002Ukena et al, , 2003.…”

Section: Discussionmentioning

confidence: 99%

“…with either GnIH (200 ng in 4 μl sterile avian saline) or 4 μl sterile avian saline. Dosage of GnIH was calculated based upon amounts of GnIH detected in quail brain (Tsutsui et al, 2000), and infusions took place 7 days after initial cannulation (2 days after testing of cannula patency). Blood samples were collected from the brachial vein at 5 and 20 min post-infusion.…”

Section: Experiments 1: Effect Of Icv Gnih Upon Plasma Luteinizing Hormentioning

confidence: 99%

“…A recently discovered neuropeptide, gonadotropin-inhibitory hormone (GnIH), acts in opposition to GnRH-I (Tsutsui et al, 2000). GnIH is a novel hypothalamic dodecapeptide having a C-terminal RF-amide motif (first identified in quail as SIKPSAYLPLRF-NH2; Tsutsui et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…GnIH is a novel hypothalamic dodecapeptide having a C-terminal RF-amide motif (first identified in quail as SIKPSAYLPLRF-NH2; Tsutsui et al, 2000). GnIH administration decreases plasma LH in vitro and in vivo in birds and in mammals (Tsutsui et al, 2000Osugi et al, 2004;Bentley et al, in press). Furthermore, in vivo GnIH administration to quail for 2 weeks via osmotic pumps decreases the expressions of gonadotropin common α and LH β-subunit mRNAs in a dose-dependent manner, with a knock-on effect of reducing plasma testosterone (Ubuka et al, in press).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Rapid inhibition of female sexual behavior by gonadotropin-inhibitory hormone (GnIH)

Bentley

Jensen

Kaur

et al. 2006

Hormones and Behavior

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167

119

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TitleRapid inhibition of female sexual behavior by gonadotropin-inhibitory hormone (GnIH). Abstract Gonadotropin-releasing hormone (GnRH) is largely responsible for the initiation of sexual behaviors; one form of GnRH activates a physiological cascade causing gonadal growth and gonadal steroid feedback to the brain, and another form is thought to act as a neurotransmitter to enhance sexual receptivity. In contrast to GnRH, gonadotropin-inhibitory hormone (GnIH) inhibits gonadotropin release. The distribution of GnIH in the avian brain suggests that it has not only hypophysiotropic actions but also unknown behavioral actions. GnIH fibers are present in the median eminence (ME) and are in apparent contact with chicken GnRH (cGnRH)-I and -II neurons and fibers. In birds, cGnRH-I regulates pituitary gonadotropin release, whereas cGnRH-II enhances copulation solicitation in estradiol-primed females exposed to male song. In the present study, we determined the effects of GnIH administered centrally to female white-crowned sparrows. A physiological dose of GnIH reduced circulating LH and inhibited copulation solicitation, without affecting locomotor activity. Using rhodaminated GnIH, putative GnIH binding sites were seen in the ME close to GnRH-I fiber terminals and in the midbrain on or close to GnRH-II neurons. These data demonstrate direct effects of GnIH upon reproductive physiology and behavior, possibly via separate actions on two forms of GnRH.

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Section: Discussionmentioning

confidence: 99%

Section: Experiments 1: Effect Of Icv Gnih Upon Plasma Luteinizing Hormentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Rapid inhibition of female sexual behavior by gonadotropin-inhibitory hormone (GnIH)

Bentley

Jensen

Kaur

et al. 2006

Hormones and Behavior

Self Cite

167

119

View full text Add to dashboard Cite

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Neuroendocrine Control of Estrus and Ovulation

Amstalden

Williams

2014

Bovine Reproduction

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Seasonal Control of the GnRH Neuronal Network as a Means of Uncovering Novel Central Mechanisms Governing Mammalian Reproduction

Milesi

Klosen

Simonneaux

2018

The GnRH Neuron and Its Control

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The ovarian cycle and ovulation in the female, and spermatogenesis in the male, are dependent upon the brain, and specifically upon a diffusely distributed network of peptidergic neurons in the hypothalamus that synthesize the neurohormone, gonadotropin-releasing hormone (GnRH). The decapeptide was isolated in 1971 from bovine and ovine hypothalami by the laboratories of Andrew Schally and Roger Guillemin, respectively (Matsuo et al., 1971;Amoss et al., 1971), and initially termed luteinizing hormone releasing hormone (LH-RH) or luteinizing hormone releasing factor (LRF). This review provides a brief historical account of the development of the concepts underpinning current research on the GnRH neuron and its control.

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A Novel Avian Hypothalamic Peptide Inhibiting Gonadotropin Release

Cited by 749 publications

References 29 publications

Rapid inhibition of female sexual behavior by gonadotropin-inhibitory hormone (GnIH)

Rapid inhibition of female sexual behavior by gonadotropin-inhibitory hormone (GnIH)

Neuroendocrine Control of Estrus and Ovulation

Seasonal Control of the GnRH Neuronal Network as a Means of Uncovering Novel Central Mechanisms Governing Mammalian Reproduction

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