A novel balloon technique to induce intra‐abdominal hypertension and its effects on cardiovascular parameters in a conscious dog model

Abstract

The balloon device was successfully insufflated and led to sustained IAH in conscious dogs. This balloon technique does not require general anesthesia for instillation or removal of gas after installment. An acute IAP increase in normal conscious dogs induced discomfort, vomiting, and increased respiratory effort.

Effect of intra‐abdominal hypertension on plasma exogenous creatinine clearance in conscious and anesthetized dogs

“…In addition, the animals in these models need specific insufflators and general anesthesia in order to develop an increase in IAP. Although an intra‐abdominal balloon had the limitation of a homogenous increase in IAP, insufflation of an intra‐abdominal balloon induces IAH without peritoneal absorption, resulting in minimal systemic effects on the respiratory and gastrointestinal systems . Fourth, in the AC and A25 treatment conditions, 0.9% sodium chloride solution was administered at a rate of 2 mL/kg/h.…”

“…Although an intra-abdominal balloon had the limitation of a homogenous increase in IAP, insufflation of an intraabdominal balloon induces IAH without peritoneal absorption, resulting in minimal systemic effects on the respiratory and gastrointestinal systems. 27 Fourth, in the AC and A25 treatment conditions, 0.9% sodium chloride solution was administered at a rate of 2 mL/kg/h. The fluid rates of 5-10 mL/kg/h are recommended to maintain fluid volume and hydration under general anesthesia.…”

“…After intubation, anesthesia was maintained with 2% isoflurane in oxygen delivered through a semiclosed circle system. The abdominal region was prepared aseptically and the balloon device for induction of IAH was placed in the abdominal cavity through a ventral midline incision . The abdominal wall was sutured, leaving only the urinary catheter port of the device accessible from the outside of the abdominal cavity.…”

“…Most of the studies on IAH/ACS have been performed in the abdominal surgical and general anesthesia setting . In a previous study, a balloon device was developed to induce and maintain IAH in conscious dogs and the device successfully increased IAP without general anesthesia in conscious dogs . This IAH dog model may be helpful for predicting kidney function in conscious patients because anesthetic agents can decrease cardiac output and reduce renal blood flow, which in turn decreases the GFR …”

“…[13][14][15][16][17][18][19][23][24][25][26] In a previous study, a balloon device was developed to induce and maintain IAH in conscious dogs and the device successfully increased IAP without general anesthesia in conscious dogs. 27 This IAH dog model may be helpful for predicting kidney function in conscious patients because anesthetic agents can decrease cardiac output and reduce renal blood flow, which in turn decreases the GFR. 25 Therefore, the purpose of this study was to evaluate the effect of increased IAP on plasma exogenous creatinine clearance in conscious and anesthetized canine IAH models.…”