A novel biodegradable biliary stent in the endoscopic treatment of cystic-duct leakage after cholecystectomy

Laukkarinen, Johanna; Nordback, Isto; Mikkonen, Joonas; Sand, Juhani

doi:10.1016/j.gie.2006.11.059

Cited by 60 publications

(42 citation statements)

References 17 publications

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“…The prevalence of post-ERCP pancreatitis in our series was 3.9%, which is within the range of previous studies (3.8-10%) [5,[19][20][21][22][23][24]. The severity of pancreatitis varies from a minor inconvenience requiring only 1 or 2 days of hospitalisation with full recovery to a devastating illness with pancreatic necrosis, multiorgan failure, permanent disability, and even death.…”

Section: Discussionsupporting

confidence: 80%

ERCP in a cohort of 759 cases: A 6-year experience of a single tertiary centre in Libya

Tumi

Magadmi

Elfageih

et al. 2015

Arab Journal of Gastroenterology

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Section: Discussionsupporting

confidence: 80%

ERCP in a cohort of 759 cases: A 6-year experience of a single tertiary centre in Libya

Tumi

Magadmi

Elfageih

et al. 2015

Arab Journal of Gastroenterology

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“…It should be considered that the persistence of chronic inflammatory effect and of fibroblastic reaction in the bile duct in which the bile stent has already been removed occurred due to bacteria in the bile at the time of endoscopic drainage. Regarding the type of material of the prostheses, both plastic, metal and, more recently, the biodegradable not differ in terms of histology, bile duct or serum determinations, and the findings of previous studies of the latter with low or no toxicity 19 . In the present study was demonstrated that more strongly reaction of collagen and relationship between elastin and collagen occurred at the 15 days, meaning hystologic events in the lumen and mainly in the extrahepatic biliary wall.…”

Section: Discussionmentioning

confidence: 89%

Effects of plastic stenting in commom bile duct of rats: a quantitative reaction analysis using collagen and elastin morphometry

Artifon¹,

Lopasso²,

Moura³

et al. 2010

Acta Cir. Bras.

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Effects of plastic stenting in commom bile duct of rats. A quantitative reaction analysis using collagen and elastin morphometry ABSTRACT Purpose: To evaluate the effects of biliary stenting in rats through analysis of collagen and elastin deposition in the bile ducts. Methods: Twenty male rats underwent midline laparotomy, duodenotomy and transampullary stenting of the common bile duct with a 22Fr plastic stent. Animals were randomized in 4 groups, with 5 components in each: (I) control, (II) biliary stenting for 7 days, (III) biliary stenting for 14 days, and (IV) biliary stenting for 30 days. Sections of the common bile duct were stained using Hematoxylin Eosin; Sirius Red to quantitate the amount of collagen present; and Weigert's Resorcin-fuchsin to quantitate the amount of elastin present. Results: The percentage of area stained for collagen was 13.4; 21.5; 29.5 and 32.8, for groups I to IV, respectively. The percentage of area stained for elastin fibers was 7.0; 5.2; 4.0 and 2.9, for groups I to IV, respectively. Collagen/Elastin ratio was 2.4; 5.1; 11.0 and 14.4 for groups I to IV, respectively. Conclusions: The biliary stenting leads to collagen and elastin deposition in the bile ducts; and collagen deposition and collagen/elastin ratio are proportional to the period of stenting. Key words: Prostheses and Implants. Collagen. Elastin. Common Bile Duct. Rats. RESUMOObjetivo: Avaliar os efeitos da colocação de prótese biliar em ratos, analisando a deposição de colágeno e elastina no hepatocolédoco. Métodos: Vinte ratos machos foram submetidos à laparotomia mediana, duodenotomia e colocação transpapilar de uma prótese plástica 22Fr no hepatocolédoco. Os animais foram randomizados em 4 grupos, com cinco componentes cada: (I) controle, (II) prótese biliar por 7 dias, (III) prótese biliar durante 14 dias e (IV) prótese biliar por 30 dias. Cortes do hepatocolédoco foram corados com Hematoxilina Eosina; Sirius Red para quantificar o colágeno; e Resorcina-fucsina de Weigert para quantificar a elastina. Resultados: A porcentagem de área corada para colágeno foi de 13,4; 21,5; 29,5 e 32,8 para os grupos I a IV, respectivamente. A porcentagem de área corada para fibras de elastina foi de 7,0; 5,2; 4,0 e 2,9, para os grupos I a IV, respectivamente. A razão colágeno / elastina foi de 2,4, 5,1, 11,0 e 14,4 para os grupos I a IV, respectivamente. Conclusões: O implante da prótese biliar leva à deposição de colágeno e elastina nos ductos biliares; e a deposição de colágeno e a relação colágeno / elastina são proporcionais ao tempo de permanência da prótese. Descritores: Próteses e Implantes. Colágeno. Elastina. Ducto Colédoco. Ratos.

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“…More importantly the maintained dilatation preserves the lumen over 3-5 months [12][13][14][15][16], potentially allowing remodelling of the stricture around the stent and increasing long-term patency, as seen in our patients.…”

Section: Discussionmentioning

confidence: 96%

“…Many of these are well-established materials for suture materials and surgical prostheses. The degradation rate of biodegradable stents depends on the fibre diameter, structure of the stent mesh, the material used, temperature, pH and type of tissue in which the stent is implanted [15]. The polymers are often degraded by hydrolysis which attacks firstly the amorphous and crystalline structure of individual stent filaments [16].…”

Section: Introductionmentioning

confidence: 99%

Biodegradable polydioxanone stents: a new option for therapy-resistant anastomotic strictures of the colon

et al. 2011

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A novel biodegradable biliary stent in the endoscopic treatment of cystic-duct leakage after cholecystectomy

Cited by 60 publications

References 17 publications

ERCP in a cohort of 759 cases: A 6-year experience of a single tertiary centre in Libya

ERCP in a cohort of 759 cases: A 6-year experience of a single tertiary centre in Libya

Effects of plastic stenting in commom bile duct of rats: a quantitative reaction analysis using collagen and elastin morphometry

Biodegradable polydioxanone stents: a new option for therapy-resistant anastomotic strictures of the colon

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