A Novel Bionic Catalyst-Mediated Drug Delivery System for Enhanced Sonodynamic Therapy

Abstract

Ultrasound (US)-triggered sonodynamic therapy (SDT) proves itself to be a formidable tool in the fight against cancer, due to its large spectrum of uses as a non-invasive therapeutic measure, while also demonstrating itself to be a certain improvement upon traditional SDT therapeutics. However, tumor hypoxia remains to be a major challenge for oxygen-dependent SDT. This study describes the development of an innovative, multi-use, catalyst-based and improved SDT targeting cancer, through the employment of a sonosensitizing curcumin (Cur) load embedded within a MnO2 core, together with an extraneous tumor cell membrane component. The latter allows for efficient tumor recognition properties. Hollowed-out MnO2 allows for efficient drug delivery, together with catalyzing oxygen generation from hydrogen peroxide present in tumor tissue, leading to enhanced SDT efficacy through the induction of a reduced hypoxic state within the tumor. In addition, Cur acts as a cytotoxic agent in its own right. The results deriving from in vivo studies revealed that such a biomimetic approach for drug-delivery actually led to a reduced hypoxic state within tumor tissue and a raised tumor-inhibitory effect within mouse models. Such a therapeutic measure attained a synergic SDT-based tumor sensitization treatment option, together with the potential use of such catalysis-based therapeutic formulations in other medical conditions having hypoxic states.

Nano-Innovations in Cancer Therapy: The Unparalleled Potential of MXene Conjugates

“…The authors claim that the remarkable performance of their biosensor can be ascribed to the unique attributes of MXene and BLM. Recent findings have integrated the biomimetic characteristics of MXenes for diverse applications, such as the detection of miRNA-135b [ 132 ], cuproptosis-based immunotherapy [ 133 ], and the design of cascaded-enzyme nanoreactors [ 134 ]. To summarize, the use of biomimetic approaches to alter MXenes holds great potential for various nanoscale biomedical applications.…”

Advances in cell membrane-based biomimetic nanodelivery systems for natural products

“…To improve the therapeutic efficacy of PDT, Cur-loaded MnO 2 nanoparticles were coated with cancer cell membrane. The resulting nanosystem evaded immune clearance and supported Cur-based sonodynamic therapy in parallel with the compound’s ability to stimulate apoptosis and inhibit proliferation (Yang et al., 2021 ). In addition, the MnO 2 nanoparticles acted as catalase to alleviate hypoxia in the acidic tumor microenvironment.…”

Biomimetic Targeting Nanoadjuvants for Sonodynamic and Chronological Multi‐Immunotherapy against Holistic Biofilm‐Related Infections

“…A compelling strategy for BRI treatment is sonodynamic therapy (SDT), a cutting-edge treatment approach that utilizes low-intensity ultrasound (US) and sonosensitizers to generate ROS, eliminate dense EPS, and kill bacteria that have detached from biofilms. [22][23][24] Unlike conventional photodynamic therapy, which is limited to treating skin lesions, [8][9][10] SDT takes advantage of the superior tissue penetrability and non-invasiveness of US, making it highly promising for addressing deep-seated diseases. [25][26][27] However, free sonosensitizers have inherent limitations that seriously impede their SDT effectiveness, such as instability, poor solubility, lack of target specificity, suboptimal sonodynamic properties, and susceptibility to decomposition.…”