A novel block copolymer with excellent amphiphobicity synthesized via ARGET ATRP

Tao, Qian; Wang, Juanjuan; Cheng, Tiantian; Zhan, Xiaoli; Zhang, Qinghua; Chen, Fengqiu

doi:10.1002/pola.28070

Cited by 13 publications

(5 citation statements)

References 33 publications

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“…AIBN (0.03%, based on the molar ratio of total monomers), HEMA, GMA and DMF (200%, based on the total weight of monomers) were added to test tube. After aeration of N 2 for 15 min, the tube was sealed and placed into an oil bath, with 70°C to react for a given time under magnetic stirring (the reaction time should ensure that the conversion rate was less than 10%) (Qian et al , 2016; Terashima et al , 2015). After that, the products were diluted by adding 10 mL DMF and the reactants were precipitated using 150 mL anhydrous ether under vigorous stirring.…”

Section: Methodsmentioning

confidence: 99%

“…In fact, there are also some reports about applying the temperature-sensitive resin with LCST as a carrier to immobilized enzyme (Zhang et al , 2016; Tao et al , 2011). However, above reports did not explored the influence of the microenvironment of carriers, such as monomer ratio, composition and structure, on the catalytic activity of the immobilized enzyme (Qian et al , 2016). The reason of choosing resins as the carrier was that the structure and composition of the resin are easily controlled.…”

Section: Introductionmentioning

confidence: 99%

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Design and synthesis of thermosensitive target segment resin with precisely controlled distance between immobilization sites for immobilization of penicillin G acylase

Liu

et al. 2023

PRT

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Purpose To save the economic cost and improve the performance of enterprises, this study aims to synthesize high performance immobilized penicillin G acylase (PGA) carriers with fast reaction speed, high recovery rate of enzyme activity and good reusability through corresponding theoretical guidance and experimental exploration. Design methodology approach A diblock resin was synthesized by reversible addition-fragmentation chain transfer polymerization method using N, N-diethylacrylamide (DEA) and β-hydroxyethyl methacrylate (HEMA) as functional monomers poly(N, N-diethylacrylamide)-b-poly(β-hydroxyethyl methacrylate) (PDEA-b-PHEMA) was obtained, and the effect of the ratio of DEA and HEMA on the activity of PGA was investigated, and the appropriate block ratio of DEA and HEMA was obtained. After that, the competitive rate of HEMA and glycidyl methacrylate (GMA) under the carrier preparation conditions was investigated. Based on the above work, a thermosensitive resin carrier PDEA-b-PHEMA-b-P(HEMA-co-GMA) with different target distances was synthesized, and the chemical structures and molecular weight of copolymers were investigated by hydrogen NMR (1H NMR). Findings The lower critical solution temperature of the resin support decreases with the increase of the monomer HEMA in the random copolymerization; the catalytic performance study indicated that the response rate of the immobilized PGA is fast, and the recovery rate of the enzyme activity of the immobilized PGA varies with the distance between the targets. When the molar ratio of HEMA to GMA in the resin block is 8.15:1 [i.e. resin PDEA100-b-PHEMA10-b-P(HEMA65-co-GMA8)], the activity recovery rate of immobilized PGA can reach 50.51%, which was 15.49% higher than that of pure GMA immobilized PGA. Originality value This contribution provides a novel carrier for immobilizing PGA. Under the optimal molar ratio, the enzyme activity recovery could be up to 50.51%, which was 15.49% higher than that of PGA immobilized on the carrier with nonregulated distance between two immobilization sites.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Design and synthesis of thermosensitive target segment resin with precisely controlled distance between immobilization sites for immobilization of penicillin G acylase

Liu

et al. 2023

PRT

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“…8,9 As the experimentally straightforward method, "grafting to" refers to the precursor polymers synthesized via different polymerization approaches reacting with suitable surface groups to form the tethered polymer chains, such as the combination of different atom transfer radical polymerization (ATRP), reversible addition-fragmentation chaintransfer (RAFT), and "Click" methods. [10][11][12] The grafted layer thicknesses are defined and limited by the average molar mass of the pre-synthesized polymers. 13 In contrast, "grafting from" is a bottom-up approach in which polymer chains are grown via surface-initiated polymerization from a substrate modified with functional groups that can initiate a polymerization reaction.…”

Section: Introductionmentioning

confidence: 99%

“…Polymer chains can be prepared by “grafting to” as well as “grafting from” methods 8,9 . As the experimentally straightforward method, “grafting to” refers to the precursor polymers synthesized via different polymerization approaches reacting with suitable surface groups to form the tethered polymer chains, such as the combination of different atom transfer radical polymerization (ATRP), reversible addition‐fragmentation chain‐transfer (RAFT), and “Click” methods 10–12 . The grafted layer thicknesses are defined and limited by the average molar mass of the pre‐synthesized polymers 13 .…”

Section: Introductionmentioning

confidence: 99%

High‐efficient surface tailoring via reverse atom transfer radical polymerization and reversible addition‐fragmentation chain‐transfer polymerization in an aqueous system initiated by a monocenter redox pair

Cai

Jiang

Cao

et al. 2022

Journal of Polymer Science

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The commonly used multi-center initiation methods always lead to the formation of quantities of homopolymer in the surface tailoring based on reverse atom transfer radical polymerization (ATRP) and reversible addition-fragmentation chaintransfer (RAFT) polymerization. In this study, a monocenter redox pair constructed of silica bearing tert-butyl hydroperoxide groups and ascorbic acid (SiO 2 -TBHP/AsAc) was applied to substitute the commonly used initiation method of R-supported RAFT grafting polymerization. All the propagating radicals were restricted on the surface of solid particles during the whole procedure theoretically, resulting in a higher grafting efficiency of 95.1% combined with the "controllable" feature at 10 h. This redox pair was also used to initiate the reverse ATRP in miniemulsion successfully with a grafting efficiency of 86.3% at 10 h.The grafting efficiency obtained under this monocenter initiation method was significantly higher than that of the frequently reported surface modification by reverse ATRP and RAFT polymerization. In addition, the high-efficient surface tailoring was traced and confirmed by nuclear magnetic resonance, Fourier transform infrared, X-ray photoelectron spectroscopy, thermogravimetric analysis, transmission electron microscopy, and other analysis tests. The advantage of this monocenter redox pair will open a new avenue for the potential "high-efficient" surface tailoring of various materials.

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“…74 Techniques for the Synthesis of Well-Defined, End Group Preserved Polymers 15 methacrylates 85 and styrene 86 or formation of block copolymers. 87,88 Overall ATRP is a powerful technique for the synthesis of defined macromolecular architectures. 89 The advantages of the strategy are the commercial availability of the conventional reagents such as initiators, ligands and the metal catalysts.…”

Section: Figurementioning

confidence: 99%

From UV to NIR light, photo-triggered 1,3 dipolar cycloadditions as a modern ligation method in solution and on surface

Lederhose¹

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angefertigt.Ich erkläre hiermit, dass ich die vorliegende Arbeit im Rahmen der Betreuung durch Prof. tracking. In addition, the trigger wavelength of the pyrene functionalized tetrazole was extended deep into the NIR range via the combination of the NITEC with upconversion nanoparticles (UCNPs). Assisted by the UCNPs, photoinduced ligation of both, small and macromolecules was obtained with irradiation at 974 nm. Full conversion and rapid formation of the desired pyrazoline cycloadducts were observed. In addition, a block copolymer featuring the biological relevant biotin moiety was prepared via NITEC at 974 nm, demonstrating the suitability of the approach for applications in the field of biology. Biotin was found to retain bioactivity after being exposed to the NITEC reaction conditions. The efficient penetration ability of the NIR irradiation applied was verified by 'through tissue' conjugation experiments. After the NITEC reaction was demonstrated to be a powerful ligation tool in solution, the concept was employed for the modification of surfaces in a λ-orthogonal approach. The selective ability of the pyrene tetrazole and an UV-active diaryl tetrazole to undergo independent NITEC reactions at 410 -420 nm, and 320 nm respectively, was demonstrated in solution. Importantly, the UV-active tetrazole remains unreacted if exposed to visible light, even for prolonged irradiation times. Subsequently, a surface grafted with pyrene functional tetrazole and UV-active tetrazole was prepared and utilized for formation of advanced patterned surfaces.

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A novel block copolymer with excellent amphiphobicity synthesized via ARGET ATRP

Cited by 13 publications

References 33 publications

Design and synthesis of thermosensitive target segment resin with precisely controlled distance between immobilization sites for immobilization of penicillin G acylase

Design and synthesis of thermosensitive target segment resin with precisely controlled distance between immobilization sites for immobilization of penicillin G acylase

High‐efficient surface tailoring via reverse atom transfer radical polymerization and reversible addition‐fragmentation chain‐transfer polymerization in an aqueous system initiated by a monocenter redox pair

From UV to NIR light, photo-triggered 1,3 dipolar cycloadditions as a modern ligation method in solution and on surface

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