A novel chalcone derivative from Punica granatum peel inhibits LOX/COX enzyme activity

Sudheesh, Siji; Soumya, K.; James, Jesna

doi:10.1016/j.bjbas.2018.07.001

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…The anti-inflammatory and antinociceptive activity of PP extract has been verified through different manners of administration: oral, gel, nano-emulsions, intraperitoneal, and intra-cerebroventricular (Lansky and Newman 2007 ; Janardan Salwe et al 2014 ; González-Trujano et al 2015 ; Nirwana 2018 ). This is in agreement with other studies regarding in vivo and in vitro assays (Verotta et al 2018 ; Sudheesh et al 2018 ; Mastrogiovanni et al 2019 ). An extract of the whole pericarp also showed anti-inflammatory activity in damaged mice and albino rats (Syeda 2018 ; Wang et al 2014 ).…”

Section: Evolution Of Scientific Interestsupporting

confidence: 93%

Pomegranate variety and pomegranate plant part, relevance from bioactive point of view: a review

Melgarejo-Sánchez

Núñez-Gómez

Martínez-Nicolás

et al. 2021

Bioresour. Bioprocess.

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Pomegranate (Punica granatum L.) belongs to the Punicaceae plant family. It is an important fruit due to its nutritional and medicinal properties. Pomegranates are widely distributed around the world and, therefore, have a broad genetic diversity, resulting in differences in their phytochemical composition. The scientific community has focused on the positive health effects of pomegranate as a whole, but the different varieties have rarely been compared according to their bioactive compounds and bioactivity. This review aims to provide a holistic overview of the current knowledge on the bioactivity of pomegranate trees, with an emphasis on differentiating both the varieties and the different plant parts. This review intends to provide a general and organized overview of the accumulated knowledge on pomegranates, the identification of the most bioactive varieties, their potential consumption pathways and seeks to provide knowledge on the present gaps to guide future research.

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Section: Evolution Of Scientific Interestsupporting

confidence: 93%

Pomegranate variety and pomegranate plant part, relevance from bioactive point of view: a review

Melgarejo-Sánchez

Núñez-Gómez

Martínez-Nicolás

et al. 2021

Bioresour. Bioprocess.

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“…Inflammation is a localized reaction of living mammalian tissues to damage . White blood cell activation, immune system chemical release, creation of inflammatory mediators, and release of prostaglandins are all components of inflammatory processes …”

Section: Pharmacological Properties Of Pomegranate Peelmentioning

confidence: 99%

“… 55 White blood cell activation, immune system chemical release, creation of inflammatory mediators, and release of prostaglandins are all components of inflammatory processes. 56 Punica granatum peels have long been employed in a variety of diseases treatments such as inflammation. 57 …”

Section: Pharmacological Properties Of Pomegranate Peelmentioning

confidence: 99%

Pomegranate Peel Phytochemistry, Pharmacological Properties, Methods of Extraction, and Its Application: A Comprehensive Review

Singh,

Kaur,

Verma

et al. 2023

ACS Omega

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Pomegranate peel, derived from the processing of Punica granatum L. (pomegranate), has traditionally been considered agricultural waste. However, recent studies have revealed its potential as a rich source of bioactive compounds with diverse pharmacological effects. Pomegranate peel is a rich reservoir of antioxidants, polyphenols, dietary fiber, and vitamins, which contribute to its remarkable bioactivity. Studies have demonstrated the anti-inflammatory, cardioprotective, wound healing, anticancer, and antimicrobial properties of pomegranate peel owing to the presence of phytochemicals, such as gallic acid, ellagic acid, and punicalagin. The extraction of bioactive compounds from pomegranate peel requires a careful selection of techniques to maximize the yield and quality. Green extraction methods, including pressurized liquid extraction (PLE), ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE), and enzyme-assisted extraction (EAE), offer efficient and sustainable alternatives to traditional methods. Furthermore, pomegranate peel has been utilized in the food industry, where it can significantly enhance the nutritional value, organoleptic characteristics, and shelf life of food products. Pomegranate peel has the potential to be used to develop innovative functional foods, nutraceuticals, and other valueadded products, providing new opportunities for the pharmaceutical, cosmetic, and food industries.

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The whole pomegranate (Punica granatum. L), biological properties and important findings: A review

Valero-Mendoza

Meléndez-Rentería

Chávez‐González

et al. 2023

Food Chemistry Advances

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A novel chalcone derivative from Punica granatum peel inhibits LOX/COX enzyme activity

Cited by 4 publications

References 16 publications

Pomegranate variety and pomegranate plant part, relevance from bioactive point of view: a review

Pomegranate variety and pomegranate plant part, relevance from bioactive point of view: a review

Pomegranate Peel Phytochemistry, Pharmacological Properties, Methods of Extraction, and Its Application: A Comprehensive Review

The whole pomegranate (Punica granatum. L), biological properties and important findings: A review

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