A novel chimeric vaccine containing multiple epitopes for simulating robust immune activation against Klebsiella pneumoniae
Morteza Hakimian,
Abbas Doosti,
Ali Sharifzadeh
Abstract:Background
Due to antibiotic resistance, the Klebsiella genus is linked to morbidity and death, necessitating the development of a universally protective vaccine against Klebsiella pathogens.
Methods
Core sequence analysis prioritized non-redundant host molecules and expected lipid bilayer peptides from fully sequenced Klebsiella genomes. These proteins were refined to identify epitopes, examining their immunogenicity, toxicity, solubility, and int… Show more
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