A Novel Clerodane Diterpene from &lt;i&gt;Vitex cofassus&lt;/i&gt;

Rasyid, Faradiba Abdul; Fukuyoshi, Shuichi; Ando, Hirokazu; Miyake, Katsunori; Atsumi, Toshiyuki; Fujie, Tetsuo; Saito, Yohei; Goto, Masuo; Shinya, Tomohiro; Mikage, Masayuki; Sasaki, Yohei; Nakagawa‐Goto, Kyoko

doi:10.1248/cpb.c16-00775

Cited by 13 publications

(11 citation statements)

References 25 publications

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“…In addition, the methanol extract of this plant displayed an ability to inhibit cell growth in several human cell lines such as HUVECs stimulated by vascular endothelial growth factor. [ 18 ] Previous chemical studies involving V. cofassus indicated the presence of various types of compounds, including a novel clerodane diterpene with antiproliferative activities, against lung carcinoma (A549), epidermoid carcinoma (KB), vincristine-resistant KB subline (KB-VIN), triple-negative breast cancer (MDA-MB-231), and estrogen receptor–positive breast cancer (MCF-7), with IC 50 values of 5.4 to 11.4 µM. [ 18 ]…”

Section: Discussionmentioning

confidence: 99%

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Chemical composition and bioactivity of Vitex cofassus Reinw. extracts on the larval and pupal stages of Aedes aegypti

et al. 2020

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Aims and Objectives: This study sought to investigate the chemical composition, larvicidal, and cytotoxic potentials of the fruit extract of Vitex cofassus Reinw. Materials and Methods: The chemical composition was analyzed using the gas chromatography–mass spectrometry technique. Separately, mortality data were evaluated by probit analysis to determine the lethal concentration (LC) 50 and LC 90 values on brine shrimp and Aedes aegypti larvae. Moreover, the effects on different stages of Ae. aegypti were also examined. Results: Fourteen majority components representing carboxylic acid were identified. The extract was very toxic to both brine shrimp and Ae. aegypti larvae with LC 50 values of 0.308 and 0.514 µg/mL, whereas the LC 90 values were 4.317 and 1.921 µg/mL, respectively. The effect of the fruit extract of V. cofassus on different stages of Ae. aegypti indicated that high concentrations (2.00–4.00 µg/mL) promoted complete mortality. A concentration of 0.125 to 1.00 µg/mL inhibited larval metamorphosis. Conclusion: To the best of our knowledge, this is the first study to evaluate the chemical composition and larvicidal effects of the fruit extract of V. cofassus . The results indicate that the extract may be a promising source of larvicidal compounds that could be useful for pharmaceutical applications.

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Section: Discussionmentioning

confidence: 99%

“…[ 17 ] More recently, Rasyid et al . [ 18 ] reported on a new clerodane diterpene, 16-hydroxy-pentadralactone acuminolide, as an anticancer agent against human umbilical vein endothelial cells (HUVECs) that was isolated from the methanol extract of V. cofassus .…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and bioactivity of Vitex cofassus Reinw. extracts on the larval and pupal stages of Aedes aegypti

et al. 2020

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“…Powder Samples of BS (Caesalpinia sappan L.) leaves which have been taken, then cleaned by washing with running water, then dried in a drying cabinet with 40-50 o C temperature. After that, it is powded using a blender, and then the sample is ready to be extracted (Rasyid et al, 2017).…”

Section: Research Methods Ii1 Preparation Of Biancaea Sappan Leavesmentioning

confidence: 99%

Spectrophotometric Determination of Total Flavonoid Content in Biancaea Sappan (Caesalpinia sappan L.) Leaves

Nurlinda

Handayani²,

Rasyid

2021

IJPF

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Biancaea sappan (BS) is traditionally used to treat anticonvulsants, anti-inflammatory, antiproliferative, anticoagulant, antiviral, immunostimulant, antioxidant, and antimicrobial treatments. Flavonoids are found in Secang; flavonoids are secondary metabolites that have antioxidant activity. This study aims to identify the flavonoids using TLC and determination of flavonoids content in BS leaves. Initially, The methanol extract of BS was obtained by maceration with ethanol. The qualitative analysis of flavonoid was using TLC and visualization by sprayed with AlCl3. The determination of total flavonoid content is conducted based on the AlCl3 method with total flavonoids expressed in QE (Quercetin equivalent) at the maximum wavelength of 431 nm. The research results showed that BS leaves contain flavonoids and the total flavonoid content of BS leaf extract is 1.0318 mg QE / g extract.Keywords: Caesalpinia sappan; Flavonoid content, Spectrophotometric

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“…13 General procedure for the synthesis of propargyl-derivatives (10a-e and 12a,b). To a stirred suspension of compound 9 (11) (5 mmol) and potassium carbonate (0.76 g, 5.5 mmol) in absolute DMF (30 mL) the propargyl bromide (5.5 mmol) was added dropwise. The reaction mixture was maintained at 50-60 o C for 5 h. Then the reaction mixture was cooled at room temperature, and water was added (50 mL).…”

Section: -[4-(azidoacetyl)piperazin-1-yl]-33-dimethyl-8-propyl-34-dihydro-1h-pyrano[34-c]pyridine-5-carbonitrile (8c)mentioning

confidence: 99%

“…For this reason, research into the development of methods for the synthesis of novel substituted triazoles is constantly increasing. 8,9 Of particular value are studies on the isolation and investigation of substances from natural raw materials that possess cytotoxic, 10 antitumor 11 activities, or being inhibitors of topoisomerase, 12 DPP-4 and cancer cell growth. 13 The main method to prepare 1,2,3-triazoles involves the 1,3-cycloaddition of organic azides with a terminal triple bond, via a click reaction.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of novel 1,2,3-triazole-based hybrids via click reactions

Sirakanyan¹,

Ghochikyan²,

Spinelli³

et al. 2021

Arkivoc

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1,2,3-Triazoles have attracted the interest of researchers due to their wide range of biological activities which include antitumor, anti-leishmanial, bioluminescent and fungicidal activities This paper describes the synthesis of novel triazole hybrids containing biologically active fragments through cycloaddition (click) reactions, with the aim of increasing the diversity of known and active 1,2,3-triazole derivatives. All new compounds have been characterized by physicochemical methods.

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A Novel Clerodane Diterpene from <i>Vitex cofassus</i>

Cited by 13 publications

References 25 publications

Chemical composition and bioactivity of Vitex cofassus Reinw. extracts on the larval and pupal stages of Aedes aegypti

Chemical composition and bioactivity of Vitex cofassus Reinw. extracts on the larval and pupal stages of Aedes aegypti

Spectrophotometric Determination of Total Flavonoid Content in Biancaea Sappan (Caesalpinia sappan L.) Leaves

Synthesis of novel 1,2,3-triazole-based hybrids via click reactions

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