A Novel Clinical Observation in Neuroleptic Malignant-Like Syndrome

Kazdal, Hızır; Kanat, Ayhan; Şen, Ahmet; Kırbaş, Serkan; Ardic, Gizem; Tüfekçi, Ahmet; Ersoz, Tahir

doi:10.1097/jcp.0000000000000293

Cited by 12 publications

(5 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In some contexts, red flags mean that something important needs to be brought to immediate attention. [ 6 ] The present study may provide a red flag and added dimension to the pathophysiologic basis of sudden death of patients with SAH in critical care unit. The findings of our study suggest that new management strategies for cervical spine at early stages after SAH for minimizing cardiopulmonary arrest are required to effectively alter the clinical course of this disease.…”

Section: Discussionmentioning

confidence: 99%

“…[ 3 4 5 ] New advances in the management of severely ill patients in the critical care unit have been observed. Even in the presence of modern technology and facilities in medical practice,[ 6 7 ] including the evolution of neurocritical care, however, their impact on sudden death following SAH is unclear. Some patients following severe SAH lapse into coma and go into cardiorespiratory arrest.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Sudden death and cervical spine: A new contribution to pathogenesis for sudden death in critical care unit from subarachnoid hemorrhage; first report – An experimental study

Kazdal

Kanat

Aydın

et al. 2017

J Craniovert Jun Spine

Self Cite

View full text Add to dashboard Cite

Context:Sudden death from subarachnoid hemorrhage (SAH) is not uncommon.Aims:The goal of this study is to elucidate the effect of the cervical spinal roots and the related dorsal root ganglions (DRGs) on cardiorespiratory arrest following SAH.Settings and Design:This was an experimental study conducted on rabbits.Materials and Methods:This study was conducted on 22 rabbits which were randomly divided into three groups: control (n = 5), physiologic serum saline (SS; n = 6), SAH groups (n = 11). Experimental SAH was performed. Seven of 11 rabbits with SAH died within the first 2 weeks. After 20 days, other animals were sacrificed. The anterior spinal arteries, arteriae nervorum of cervical nerve roots (C6–C8), DRGs, and lungs were histopathologically examined and estimated stereologically.Statistical Analysis Used:Statistical analysis was performed using the PASW Statistics 18.0 for Windows (SPSS Inc., Chicago, Illinois, USA). Intergroup differences were assessed using a one-way ANOVA. The statistical significance was set at P < 0.05.Results:In the SAH group, histopathologically, severe anterior spinal artery (ASA) and arteriae nervorum vasospasm, axonal and neuronal degeneration, and neuronal apoptosis were observed. Vasospasm of ASA did not occur in the SS and control groups. There was a statistically significant increase in the degenerated neuron density in the SAH group as compared to the control and SS groups (P < 0.05). Cardiorespiratory disturbances, arrest, and lung edema more commonly developed in animals in the SAH group.Conclusion:We noticed interestingly that C6–C8 DRG degenerations were secondary to the vasospasm of ASA, following SAH. Cardiorespiratory disturbances or arrest can be explained with these mechanisms.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sudden death and cervical spine: A new contribution to pathogenesis for sudden death in critical care unit from subarachnoid hemorrhage; first report – An experimental study

Kazdal

Kanat

Aydın

et al. 2017

J Craniovert Jun Spine

Self Cite

View full text Add to dashboard Cite

show abstract

“…The recognition of this fact may be important if indeed one is the first to report something and that something is of value. [ 57 58 59 ]…”

Section: Discussionmentioning

confidence: 99%

Ligamentum flavum hematomas: Why does it mostly occur in old Asian males? Interesting point of reported cases: Review and case report

Özdemi̇r¹,

Kanat²,

Batçık³

et al. 2016

J Craniovert Jun Spine

Self Cite

View full text Add to dashboard Cite

Hematoma of the ligamentum flavum (LF) is a rare cause of neural compression and sciatica. Currently, the etiology and epidemiological characteristics of ligamentum flavum hematoma (LFH) are unknown and epidemiological investigations using rewieving of reported cases have not been performed. We report the case of a 63-year-old man with a LFH compressing the spinal canal at the left L2–L3 level, rewieved relevant literature. In Medline research, wefound a total of 50 reported cases with LFHs, and the interesting point of these cases were analyzed. Many of cases were old males. Interestingly, 39 of the 50 cases were reported from Asian countries. The ages of 42 patients could be verified. The youngest age was 45 years, oldest age was 81 years, and mean age was 66.07 years. Thirty-three out of these 42 patients (78.53%) were older than 60 years. An important aspect of the present review is to bring attention for occurrence in older Asian males. With an increasing number of elderly people in the general population, there is a need to investigate risk factors such as sexual gender, age, and geographic location for LFH.

show abstract

“…5 It may be caused by obstruction of the flow of CSF at any point in its path, irregular absorption, or, very rarely, excessive production. 5 It is a known disease from ancient times, 6 A comprehensive understanding of pathophysiology is an important issue in medical practice. 7 Alcohol has complex effects on the brain tissue.…”

Section: Introductionmentioning

confidence: 99%

Important Finding for COVID-19 Pandemic: Hydrocephalus-producing effect of Vaporized Alcohol Disinfectant

Kanat

Aydın

Şahin

et al. 2022

J Neurol Surg A Cent Eur Neurosurg

Self Cite

View full text Add to dashboard Cite

BACKGROUND: Alcohol exposure may cause hydrocephalus. In this study, the effect of vaporized nasal alcohol exposure on the choroid plexus, ependymal cells, and developing hydrocephalus was investigated. METHODS: 24 males (∼380g) Wistar rats were used in this study. Animals were divided into three groups, as the control, SHAM and study groups. Then, the study group was again divided into two groups as exposed to light or heavy dose alcohol. The choroid plexuses and intraventricular ependymal cells and ventricles volumes were assessed and compared. RESULTS: Degenerated epithelial cells density 22±5 /mm3 in the control group, 56±11 /mm3 in the SHAM group, 175±37 /mm3 in the light, and 356±85 /mm3 in the heavy alcohol exposure group. Evan's index was less than <34% in the control, larger than >36% in the SHAM, larger than >40% in the group which was exposed to light alcohol (light alcohol group), larger than >50% in heavy alcohol (heavy alcohol group) exposed. CONCLUSIONS: It was found that alcohol exposure causes choroid plexus and ependymal cell degeneration with ciliopathy and the enlarged lateral ventricles or hydrocephalus. In the COVID-19 Pandemic Era, our findings are functionally important; alcohol has often been used for hygiene and prevention of transmission of COVID-19 pandemic.

show abstract

A Novel Clinical Observation in Neuroleptic Malignant-Like Syndrome

Cited by 12 publications

References 17 publications

Sudden death and cervical spine: A new contribution to pathogenesis for sudden death in critical care unit from subarachnoid hemorrhage; first report – An experimental study

Sudden death and cervical spine: A new contribution to pathogenesis for sudden death in critical care unit from subarachnoid hemorrhage; first report – An experimental study

Ligamentum flavum hematomas: Why does it mostly occur in old Asian males? Interesting point of reported cases: Review and case report

Important Finding for COVID-19 Pandemic: Hydrocephalus-producing effect of Vaporized Alcohol Disinfectant

Contact Info

Product

Resources

About