A novel colonoscope with panoramic visualization detected more simulated polyps than conventional colonoscopy in a live swine model

Abstract

Background and study aims: The Aer-O-Scope™ Colonoscope System (AOS) combines panoramic 360° view with standard forward view. We assessed the AOS’s ability to identify lesions implanted in live swine, compared to conventional colonoscopy (CC). Patients and methods: Twelve swine colons were surgically ligated and beads sewn within. Five procedures (3 AOS and 2 CC) were performed on each swine and findings reported. Physicians were blinded to number, size, and color of beads. The sequence of procedures and physicians was randomized. Pigs, physicians, and colonoscopes were randomly alternated between examination rooms, maintaining physician blindness. Two independent blinded physicians interpreted procedure videos offline. Results: A total of 259 /273 (94.9 %) of lesions were visualized by AOS compared to 158 /182 with CC (86.8 %) (P = 0.002). Miss rates of lesions ≥ 6 mm were 2.6 % and 10.5 %, respectively (P = 0.022), and 6.9 % and 15.1 %, respectively, for lesions < 6 mm (P = 0.031). Mean agreement between AOS and CC for lesion detection was 88.3 %. The benefit of AOS was maintained in offline video review. Conclusions: AOS, featuring panoramic 360° view, demonstrated high detection rates for simulated colonic lesions in a live swine model.

The evolution of lower gastrointestinal endoscopy: where are we now?

“…The tip contains an LED light source with irrigation, suction and a recently introduced therapeutic channel. 41 Aer-O-Scope has achieved caecal intubation rates of 98.2%, but has only visualised 87.5% of polyps seen on conventional colonoscopy. This was despite a 94.9% lesion recognition on a simulated double-blinded porcine study.…”

Emerging next‐generation robotic colonoscopy systems towards painless colonoscopy

“…This is a self‐propelling, self‐navigating and disposable colonoscope developed for diagnostic colonoscopy by GI View, Ramat Gan, Israel. It consists of an external workstation with a full joystick control and a disposable unit (Figure ) . The disposable unit consists of 3 components: a rectal introducer, a supply cable and an endoscope that is embedded within a scanning balloon that together acts as the vehicle.…”

“…The miss rates for beads larger or equal to 6 mm were 2.6% and 10.5%, whereas for beads less than 6 mm, the reported miss rates were 6.9% and 15.1%, respectively. The results of the study proposed that the 360° omnidirectional viewing capacity was superior to that of a conventional colonoscope . The efficacy of the device was evaluated in a clinical study involving 58 participants who presented for CRC screening.…”

Robotics for Advanced Therapeutic Colonoscopy

“…The colonoscope is a 5.5-mm soft multi-lumen tube with a unique pneumatic self-propulsion mechanism that uses balloons and low-pressure carbon dioxide gas for self-propelled intubation and suction. A pre-clinical study in a live swine model showed high detection rates for simulated colonic lesions [24]. A small study of 56 subjects showed that the system has a cecal intubation and polyp detection rate of 98.2% and 87.5%, respectively.…”