A novel compound targets the feline infectious peritonitis virus nucleocapsid protein and inhibits viral replication in cell culture

Mohseni, Nazleen; Royster, Austin; Ren, Shuo; Ma, Yuehui; Pintado, Melissa; Mir, Mohammad A.

doi:10.1016/j.jbc.2023.102976

Cited by 1 publication

(1 citation statement)

References 55 publications

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“…10.1.10. Miscellaneous Antiviral Treatments Some other drugs have only been investigated in vitro, and in vivo efficacy is unknown, such as vidarabine [359], which inhibits polymerase activity; nelfinavir, a commercially available protease inhibitor of human immunodeficiency virus [355]; Galanthus nivalis agglutinin, a carbohydrate-binding agent that binds to FCoV-glycosylated envelope glycoproteins, thereby inhibiting viral attachment to the host cell [355,392]; K31, a novel compound that binds and alters the conformation of the FCoV nucleocapsid protein [393]; plant-derived flavonoids (including isoginkgetin) [394]; and ERDRP-0516, a non-nucleoside inhibitor of the RNA-dependent RNA polymerase [395]. One study has shown evidence of antiviral synergy between GS-441524 and itraconazole in vitro, especially against a type I FCoV [352].…”

Section: Cyclosporine Amentioning

confidence: 99%

Feline Infectious Peritonitis: European Advisory Board on Cat Diseases Guidelines

Tasker,

Addie,

Egberink

et al. 2023

Viruses

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Feline coronavirus (FCoV) is a ubiquitous RNA virus of cats, which is transmitted faeco-orally. In these guidelines, the European Advisory Board on Cat Diseases (ABCD) presents a comprehensive review of feline infectious peritonitis (FIP). FCoV is primarily an enteric virus and most infections do not cause clinical signs, or result in only enteritis, but a small proportion of FCoV-infected cats develop FIP. The pathology in FIP comprises a perivascular phlebitis that can affect any organ. Cats under two years old are most frequently affected by FIP. Most cats present with fever, anorexia, and weight loss; many have effusions, and some have ocular and/or neurological signs. Making a diagnosis is complex and ABCD FIP Diagnostic Approach Tools are available to aid veterinarians. Sampling an effusion, when present, for cytology, biochemistry, and FCoV RNA or FCoV antigen detection is very useful diagnostically. In the absence of an effusion, fine-needle aspirates from affected organs for cytology and FCoV RNA or FCoV antigen detection are helpful. Definitive diagnosis usually requires histopathology with FCoV antigen detection. Antiviral treatments now enable recovery in many cases from this previously fatal disease; nucleoside analogues (e.g., oral GS-441524) are very effective, although they are not available in all countries.

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