A novel controllable molecularly imprinted drug delivery system based on the photothermal effect of graphene oxide quantum dots

Xu, Yarong; Hu, Xiaoling; Guan, Ping; Du, Chunbao; Tian, Yuan; Ding, Shichao; Li, Zhiling; Yan, Chaoren

doi:10.1007/s10853-019-03500-0

Cited by 42 publications

(26 citation statements)

References 67 publications

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“…In recent years, the applications of GQDs in drug delivery [123][124][125][126][127], sensors [128][129][130][131][132][133][134], bio-imaging [10,63,[135][136][137][138][139][140], magnetic hyperthermia [141][142][143], photothermal therapy [144][145][146][147][148], antibacterial [145,149,150], catalyst [69,[151][152][153][154][155], environmental protection [38,156,157], and energy [158][159][160][161][162][163] has made remarkable accomplishment. In order to better apply GQDs to drug delivery, some researchers had used density functional theory (DFT) calculations [164]…”

Section: Applications Of Gqds In Drug Deliverymentioning

confidence: 99%

“…While developing new nanomaterials, new drug delivery-release modes have also been explored. Generally, there are enhanced permeability and retention (EPR)-pH delivery-release mode [184], ligand-pH delivery-release mode [99,185,186], EPR-Photothermal Delivery-Release Mode [123], and Core/Shell-photothermal/magnetic thermal delivery-release mode [187,188]. In addition, other delivery-release modes are generally used to treat non-tumor diseases.…”

Section: Applications Of Gqds In Drug Deliverymentioning

confidence: 99%

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Synthesis of graphene quantum dots and their applications in drug delivery

et al. 2020

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This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-release modes of GQDs-based drug delivery systems such as EPR-pH delivery-release mode, ligand-pH delivery-release mode, EPR-Photothermal delivery-Release mode, and Core/Shell-photothermal/magnetic thermal delivery-release mode are reviewed. Finally, the current challenges and the prospective application of GQDs in drug delivery are discussed.

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Section: Applications Of Gqds In Drug Deliverymentioning

confidence: 99%

Section: Applications Of Gqds In Drug Deliverymentioning

confidence: 99%

Synthesis of graphene quantum dots and their applications in drug delivery

et al. 2020

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“…The loading capacity noted here is rather greater than a previous report by Zhang et al (who obtained a loading of 151.4 mg per gram of a MoS2-PEG nanocomposite) and close to that reported for graphdiyne (38%) [42][43] . The loading observed here is significantly improved over other a range of other delivery systems which have been explored in the literature, such as molecularly imprinted polymers (7.08%), polyprodrug nanoparticles (13%), or mesoporous silica nanoparticles (5.8%) [44][45][46] .…”

Section: Resultsmentioning

confidence: 99%

Synergistic Chemo-Photothermal Suppression of Cancer by Melanin Decorated MoO_x Nanosheets

Liu

Williams

et al. 2019

ACS Appl. Bio Mater.

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Two-dimensional (2D) nanomaterials able to effectively absorb near-infrared (NIR) radiation have shown considerable potential as multifunctional platforms in the treatment of cancer. Here we report a molybdenum dioxide (MoOx)-based system for synergistic chemo-and photothermal therapy of cancer. MoOx nanosheets were generated via a one-step hydrothermal route, grafted with polyethylene glycol (PEG), and decorated with melanin (Mel), with successful functionalization confirmed by IR spectroscopy. The mean diameter and thickness of the MoOx particles are found to be 302 ± 34 nm and 19 ± 2 nm using atomic force microscopy. The hydrodynamic size of the MoOx nanosheets was 105 ± 17 nm, and the final MoOx-PEG-Mel-DOX formulation had a diameter of 161 ± 26 nm). The MoOx-PEG-Mel nanosheets efficiently convert NIR light to heat, possessing a photothermal conversion efficiency of 61.7%. They can also be loaded with doxorubicin (DOX), giving a high drug loading (325.6 mg DOX / g MoOx-PEG-Mel). MoOx-PEG-Mel-DOX shows DOX release influenced by pH and NIR irradiation. Systematic in vitro and in vivo evaluations reveal that synergistic chemo-and photothermal therapy using MoOx-PEG-Mel-DOX can completely eradicate a tumor, with no observable off-target cytotoxicity. This is the first report of the fabrication of enhanced photothermal agents by combining MoOx nanosheets and a natural product. This work proffers a strategy for efficiently treating cancer, as well as potentially extending the photothermal applications of 2D nanomaterials by surface melanin functionalisation.

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“…Molecularly imprinted polymers (MIPs) are functional receptors with specific rebinding sites for targets . Due to MIPs′ predetermined selectivity and high physical/thermal stability, they have received extensive attention in SPE , biosensors and chemosensors , biomimetic catalysis , and drug delivery . However, the reported MIPs are mainly synthesized in aprotic and low‐polar organic solvents , and their molecular recognition ability was very poor in aqueous solutions because of the disturbance of water molecules, which leads to nonspecific adsorption and restricts the practical applications .…”

Section: Introductionmentioning

confidence: 99%

One‐step polymerization of hydrophilic ionic liquid imprinted polymer in water for selective separation and detection of levofloxacin from environmental matrices

Zhu

Wang

et al. 2019

J of Separation Science

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A novel green hydrophilic levofloxacin imprinted polymer was presented via onestep polymerization in water using ionic liquid 1,6-hexa-3,3 ′ -bis-1-vinylimidazolium bromine with multiple hydrophilic groups and 2-hydroxyethyl methacrylate as a cofunctional monomer. Adsorption experiment revealed that the ionic liquid significantly improved the water compatible of imprinted polymer, and the excellent recognition of molecularly imprinted polymer for levofloxacin in water corresponds to the synergetic effect of H-bonding and the electrostatic and π-π interactions between the levofloxacin and co-functional monomer. Furthermore, the adsorption process of the imprinted material towards levofloxacin fitted the Langmuir model, and the maximum binding amount of levofloxacin onto the imprinted and corresponding non-imprinted polymer were 16.45 and 6.82 mg/g at 25 • C, respectively. After optimizing the parameters affecting solid phase extraction performance, an enrichment and determination system was achieved to separate and detect levofloxacin from water and sediment samples with recoveries that ranged from 83.67 to 101.33% and relative standard deviation of less than 5.59%. K E Y W O R D Sionic liquids, levofloxacin, molecularly imprinted polymers, water

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A novel controllable molecularly imprinted drug delivery system based on the photothermal effect of graphene oxide quantum dots

Cited by 42 publications

References 67 publications

Synthesis of graphene quantum dots and their applications in drug delivery

Synthesis of graphene quantum dots and their applications in drug delivery

Synergistic Chemo-Photothermal Suppression of Cancer by Melanin Decorated MoO_x Nanosheets

One‐step polymerization of hydrophilic ionic liquid imprinted polymer in water for selective separation and detection of levofloxacin from environmental matrices

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A novel controllable molecularly imprinted drug delivery system based on the photothermal effect of graphene oxide quantum dots

Cited by 42 publications

References 67 publications

Synthesis of graphene quantum dots and their applications in drug delivery

Synthesis of graphene quantum dots and their applications in drug delivery

Synergistic Chemo-Photothermal Suppression of Cancer by Melanin Decorated MoOx Nanosheets

One‐step polymerization of hydrophilic ionic liquid imprinted polymer in water for selective separation and detection of levofloxacin from environmental matrices

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Synergistic Chemo-Photothermal Suppression of Cancer by Melanin Decorated MoO_x Nanosheets