A novel controlled drug delivery system based on alginate hydrogel/chitosan micelle composites

Cong, Zhaotong; Shi, Yanbin; Wang, Yang; Wang, Yanhong; Jing, Niu; Chen, Nana; Xue, Haoyue

doi:10.1016/j.ijbiomac.2017.09.065

Cited by 106 publications

(53 citation statements)

References 46 publications

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“…The new hydrogel is capable of storing drugs, cytokines, growth factors, cells, and other therapeutic agents [132]. Cong et al crosslinked alginate hydrogel with chitosan micelle to create a pH-sensitive drug delivery system [133].…”

Section: Drug Delivery and Nanomedicinementioning

confidence: 99%

“…Some intravenous injection applications for drug delivery have utilized polymeric micelles ( Figure 8) [133]. Polymeric micelles have hydrophobic cores with hydrophilic shells for storage and protection for the internal substrate from the surrounding environment [133]. Cong et al fabricated a pH-sensitive and drug-loaded micelle, using emodin encapsulated by chitosan within a sodium alginate hydrogel.…”

Section: Drug Delivery and Nanomedicinementioning

confidence: 99%

“…Cong et al fabricated a pH-sensitive and drug-loaded micelle, using emodin encapsulated by chitosan within a sodium alginate hydrogel. Crosslinked micelles through chemical reactions or UV irradiation are more mechanically robust and effective for targeted release when compared to polymeric micelles [133]. The empty chitosan micelles were formulated in a drop-wise fashion of calcium chloride solution and then freeze dried for further application [133].…”

Section: Drug Delivery and Nanomedicinementioning

confidence: 99%

“…Crosslinked micelles through chemical reactions or UV irradiation are more mechanically robust and effective for targeted release when compared to polymeric micelles [133]. The empty chitosan micelles were formulated in a drop-wise fashion of calcium chloride solution and then freeze dried for further application [133]. Emodin solution was mixed in the empty micelle solution, eventually following the same drop-wise procedure.…”

Section: Drug Delivery and Nanomedicinementioning

confidence: 99%

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Protein–Polysaccharide Composite Materials: Fabrication and Applications

et al. 2020

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Protein–polysaccharide composites have been known to show a wide range of applications in biomedical and green chemical fields. These composites have been fabricated into a variety of forms, such as films, fibers, particles, and gels, dependent upon their specific applications. Post treatments of these composites, such as enhancing chemical and physical changes, have been shown to favorably alter their structure and properties, allowing for specificity of medical treatments. Protein–polysaccharide composite materials introduce many opportunities to improve biological functions and contemporary technological functions. Current applications involving the replication of artificial tissues in tissue regeneration, wound therapy, effective drug delivery systems, and food colloids have benefited from protein–polysaccharide composite materials. Although there is limited research on the development of protein–polysaccharide composites, studies have proven their effectiveness and advantages amongst multiple fields. This review aims to provide insight on the elements of protein–polysaccharide complexes, how they are formed, and how they can be applied in modern material science and engineering.

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Section: Drug Delivery and Nanomedicinementioning

confidence: 99%

Section: Drug Delivery and Nanomedicinementioning

confidence: 99%

Section: Drug Delivery and Nanomedicinementioning

confidence: 99%

Section: Drug Delivery and Nanomedicinementioning

confidence: 99%

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Protein–Polysaccharide Composite Materials: Fabrication and Applications

et al. 2020

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“…Alginates have attracted much attention as carriers for drug and cell delivery 13 . Na + ions of glucuronic acid residues interact ionically with multivalent cations (usually Ca 2+ ) and then the α-Lglucuronic acid groups can connect with each other, resulting in a three-dimensional hydrogel network which has pH-sensitive property 14 . Generally, hydrogels suffer from some serious problems, such as hydrogels are hydrated and porous like living tissues 15 and also brittle in nature 16 , which have poor mechanical strength.…”

Section: Ijpsr (2020) Volume 11 Issue 3 (Research Article)mentioning

confidence: 99%

Untitled

2020

IJPSR

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In the present work, temperature/pH-sensitive copolymer beads of chitosan (CS) coated sodium alginate/xanthan gum grafted N, N'methylenediacrylamide have been synthesized by free radical polymerization in an atmosphere of nitrogen using AIBN/Fe 2+ redox pair initiator and Tetramethylethylenediamine (TEMED) as a catalyst followed by simple ionotropic gelation technique. These beads were characterized by Fourier transform infrared (FTIR) spectroscopy, Differential scanning calorimetry (DSC), Field emission scanning electron microscopy (FESEM) Energydispersive X-ray spectra (EDS) and X-ray diffraction measurements (X-RD). DSC and X-RD studies reveal the molecular dispersion of Chlorthalidone (CT) drugs. Swelling and drug release behaviors of these beads were investigated in simulated intestinal fluid (pH 7.4) and gastric fluid (pH 2.0) at 37 ºC. Results illustrated that both the swelling and degradation of the optimized beads were influenced by the pH of the test medium, which might be suitable for intestinal drug delivery. The release mechanism was analyzed by fitting the release data into the Korsmeyer-Peppas equation.

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Unlocking the Potential of Hybrid Nanocomposite Hydrogels: Design, Mechanical Properties and Biomedical Performances

Li,

Nicolas,

Mura

2024

Adv Funct Materials

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Hybrid nanocomposite hydrogels consist of the homogeneous incorporation of nano‐objects in a hydrogel matrix. The latter, whether made of natural or synthetic materials, possesses a microporous, soft structure that makes it an ideal host for a variety of polymer and lipid‐based nano‐objects as well as metal‐ and silica‐based ones. By carefully choosing the composition and the proportions of the different constituents, hybrid hydrogels can display a wide array of properties, from simple enhancement of mechanical characteristics to specific bioactivity. This review aims to provide an overview of the state of the art in hybrid hydrogels highlighting key aspects that make them a promising choice for a variety of biomedical applications. Strategies for the preparation of hybrid hydrogels are discussed by covering the selection of individual components. The review will also explore the physico‐chemical and rheological characterization of these materials, which is essential for understanding their structure and function, ultimately satisfying specifications for the intended use. Successful examples of biomedical applications will also be presented, and the main challenges to be met will be discussed, with the aim of stimulating the research community to exploit the full potential of these materials.

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A novel controlled drug delivery system based on alginate hydrogel/chitosan micelle composites

Cited by 106 publications

References 46 publications

Protein–Polysaccharide Composite Materials: Fabrication and Applications

Protein–Polysaccharide Composite Materials: Fabrication and Applications

Untitled

Unlocking the Potential of Hybrid Nanocomposite Hydrogels: Design, Mechanical Properties and Biomedical Performances

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