A Novel Cycloartane Triterpenoid Bisdesmoside from Actaea vaginata

Abstract

A new cycloartane triterpenoid bisdesmoside, soulieoside S (1), was isolated from the ethanolic extract of rhizomes of Actaea vaginata. The structure was determined by extensive spectroscopic analysis including 1D-and 2D NMR and HRESIMS, as well as chemical methods. Compound 1 was evaluated for its cytotoxic activities against HepG2, MDA-MB231 and A549 cancer cell lines.

Discovery and synthesis of novel beesioside I derivatives with potent anti-HIV activity

“…Compounds 1-12 were isolated from S. vaginata similarly to our previous reported studies [15][16][17][18][19][20][21]. Scheme 1 outlines the general synthetic procedure leading to six derivatives 1a, 13 and 13a-d including two new ones (13b-c).…”

“…Such glycosides show various biological effects, including anti-HIV, cytotoxic, anti-acetylcholinesterase, and neuroprotective activities [11][12][13][14]. In our previous investigation on this species, we isolated a series of new cycloartane triterpene glycosides [15][16][17][18][19][20][21]. Herein, twelve known cycloartane triterpenoids with four different skeletons, beesioside I (1), beesioside K (2), soulieoside M (3), beesioside M (4), soulieoside N (5), soulieoside R (6), soulieoside Q (7), beesioside O (8), (20S,24S)-15αacetoxy-16β,24;20,24-diepoxy-3β-(β-D-xylopyranosyloxy)-9,19-cyclolanostane-18,25-diol (9), soulieoside S (10), soulieoside O (11), and soulieoside P (12) (Fig.…”