A Novel Device for Intravaginal Electronic Brachytherapy

Schneider, Frank; Fuchs, H; Lorenz, Friedlieb; Steil, Volker; Ziglio, F.; Kraus-Tiefenbacher, U.; Lohr, Frank; Wenz, Frederik

doi:10.1016/j.ijrobp.2009.01.082

Cited by 40 publications

(35 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4.3 (Schneider et al 2009b ). To analyse the isotropy, an applicator or probe shape was cut out from the fi lm and the fi lm was then placed around an applicator or the bare probe.…”

Section: Film Measurementmentioning

confidence: 96%

“…In a second step the depth dose curve, which is calculated by the INTRABEAM terminal, can be fi tted using another exponential function. Finally these two functions can be correlated to obtain an assignment of grey values to dose (Schneider et al 2009b ). However, in this approach some extra knowledge is needed to keep the compound error of the fi lm-scanner system as low as possible (Schneider et al 2009a ;Andres et al 2010 ).…”

Section: Film Measurementmentioning

confidence: 99%

See 1 more Smart Citation

Quality Assurance and Commissioning

Schneider

Clausen

Eaton

2013

Targeted Intraoperative Radiotherapy in Oncology

Self Cite

View full text Add to dashboard Cite

“…4.3 (Schneider et al 2009b ). To analyse the isotropy, an applicator or probe shape was cut out from the fi lm and the fi lm was then placed around an applicator or the bare probe.…”

Section: Film Measurementmentioning

confidence: 96%

Section: Film Measurementmentioning

confidence: 99%

Quality Assurance and Commissioning

Schneider

Clausen

Eaton

2013

Targeted Intraoperative Radiotherapy in Oncology

Self Cite

View full text Add to dashboard Cite

“…11 Solid spherical applicators were developed to deliver intraoperative radiotherapy (IORT) to the tumour bed for breast cancer, as described below. Further applicators have been designed for gynaecological, skin and kyphoplasty treatments, 12,19,20 but only a few clinical results have been reported. 21,22 The Xoft® Axxent® system (iCAD Inc., Nashua, NH) is a miniature X-ray tube integrated with a cooling sheath into a multilumen catheter, first released in 2006 (Figure 1b).…”

Section: Clinical Systemsmentioning

confidence: 99%

Electronic brachytherapy—current status and future directions

Eaton¹

2015

BJR

View full text Add to dashboard Cite

In the past decade, electronic brachytherapy (EB) has emerged as an attractive modality for the treatment of skin lesions and intraoperative partial breast irradiation, as well as finding wider applications in intracavitary and interstitial sites. These miniature X-ray sources, which operate at low kilovoltage energies (,100 kV), have reduced shielding requirements and inherent portability, therefore can be used outside the traditional realms of the radiotherapy department. However, steep dose gradients and increased sensitivity to inhomogeneities challenge accurate dosimetry. Secondly, ease of use does not mitigate the need for close involvement by medical physics experts and consultant oncologists. Finally, further studies are needed to relate the more heterogeneous dose distributions to clinical outcomes. With these provisos, the practical convenience of EB strongly suggests that it will become an established option for selected patients, not only in radiotherapy departments but also in a range of operating theatres and clinics around the world.

show abstract

“…Recently miniaturized x-ray tubes have drawn attention of researchers for medical applications [1][2][3]. Due to their small sizes these x-ray sources give an opportunity to use them inside the body for applications where close contact to the site of the target is required.…”

Section: Introductionmentioning

confidence: 99%

Miniature CNT-based X-ray tube: assessment for use in intraoperative radiation therapy

Mahmoud-Pashazadeh

Illanes

Joseph

et al. 2017

Current Directions in Biomedical Engineering

View full text Add to dashboard Cite

Carbon nanotube (CNT) is a new technology used to generate gamma photons in X-ray tubes. CNTs, in comparison to other small X-ray sources, produce high X-ray intensities and as they are not based on a thermionic principle they considered cold electron sources with a very high conversion of electrical to photon energy. Their small size and other interesting properties could make them feasible for use in intraoperative radiation therapy applications. In this study, physical characteristics of the photon beam generated by the CNT-based X-ray source were assessed. A soft X-ray ionization chamber and a flat panel detector was used to measure dose and photon counts, respectively. The repetitively produced pulses had almost the same photon intensities with differences of less than 1% between them. For a typical selected pulse, the variation in the pulse amplitude was also insignificant, which shows a stable radiation exposure of the tube during the ON-mode. When moving from the center of the beam profile to the lateral distance of 25 mm, both intensity profile and dose profile showed a falling trend by a factor of almost 3 in the measured values.We also tested the miniature tube with our novel radiation beam shaping collimator designed for a possible application to treat larynx tumor, which showed the possibility of interventional radiation therapy using this miniature source. An endoscopic camera attached to the system can also make it possible to optically visualize the radiation exposed area.In conclusion, CNT-based X-ray source with suitable attached collimator to shape the beam of the source, seems to provide an opportunity to deliver radiation to a desired tumor area in minimally invasive image guided medical procedures mainly in the normal cavities of the body.

show abstract

A Novel Device for Intravaginal Electronic Brachytherapy

Cited by 40 publications

References 37 publications

Quality Assurance and Commissioning

Quality Assurance and Commissioning

Electronic brachytherapy—current status and future directions

Miniature CNT-based X-ray tube: assessment for use in intraoperative radiation therapy

Contact Info

Product

Resources

About