A novel double-coating approach for improved pH-triggered delivery to the ileo-colonic region of the gastrointestinal tract

Liu, Feng; Moreno, P.; Basit, Abdul W.

doi:10.1016/j.ejpb.2009.11.008

Cited by 42 publications

(17 citation statements)

References 20 publications

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“…Liu et al [21] adopted dual coating approach by using the alkaline aqueous solution of Eudragit ® S with buffering agents for inner layer and the organic solution of Eudragit ® S for outer layer, accelerating the drug dissolution at pH > 7. Subsequently, Varum et al [22] evaluated in vivo performance of this dual coated system in humans, demonstrating more consistent disintegration of dual coated tablets mainly in the lower intestinal tract.…”

Section: Ph-dependent Drug Delivery Systemsmentioning

confidence: 99%

Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements

et al. 2020

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Colon targeted drug delivery systems have gained a great deal of attention as potential carriers for the local treatment of colonic diseases with reduced systemic side effects and also for the enhanced oral delivery of various therapeutics vulnerable to acidic and enzymatic degradation in the upper gastrointestinal tract. In recent years, the global pharmaceutical market for biologics has grown, and increasing demand for a more patient-friendly drug administration system highlights the importance of colonic drug delivery as a noninvasive delivery approach for macromolecules. Colon-targeted drug delivery systems for macromolecules can provide therapeutic benefits including better patient compliance (because they are pain-free and can be self-administered) and lower costs. Therefore, to achieve more efficient colonic drug delivery for local or systemic drug effects, various strategies have been explored including pH-dependent systems, enzyme-triggered systems, receptor-mediated systems, and magnetically-driven systems. In this review, recent advancements in various approaches for designing colon targeted drug delivery systems and their pharmaceutical applications are covered with a particular emphasis on formulation technologies.

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Section: Ph-dependent Drug Delivery Systemsmentioning

confidence: 99%

Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements

et al. 2020

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“…Thus, the swelling of the coated pellets was suppressed and then affected the rupture of coated pellets, retarding the drug release. Moreover, less water uptake was not beneficial to the production of microenvironments inside the pellets, delaying the dissolution of the enteric polymer coatings (28,29).…”

Section: Effect Of Blend Ratio On Drug Releasementioning

confidence: 99%

Eudragit L/HPMCAS Blend Enteric-Coated Lansoprazole Pellets: Enhanced Drug Stability and Oral Bioavailability

Wang²,

Zhang³

et al. 2014

AAPS PharmSciTech

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Abstract. The objectives of the present work were to use blends of Eudragit L and hydroxypropyl methylcellulose acetate succinate (HPMCAS) as enteric film coatings for lansoprazole (LSP) pellets. The entericcoated pellets were prepared with a fluid-bed coater. The influence of the blend ratio, type of plasticizer, plasticizer level, coating level, and curing conditions on gastric stability in vitro drug release and drug stability was evaluated. Furthermore, the bioavailability of the blend-coated pellets in beagle dogs was also performed. The blend-coated pellets exhibited significant improvement of gastric stability and drug stability compared to the pure polymer-coated pellets. Moreover, the AUC values of blend-coated pellets were greater than that of the pure polymer-coated pellets. It was concluded that the using blends of Eudragit L and HPMCAS as enteric film coatings for LSP pellets improved the drug stability and oral bioavailability.

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“…Since most pharmaceutical drugs are applied orally [1], understanding the process of the liberation of the tablets and capsules in the gastrointestinal tract is highly relevant for pharmaceutical research. This process, which involves the disintegration of the pharmaceutical into smaller pieces as well as the dissolution in the intragastric medium, can be controlled with coating technologies in order to influence the place of liberation in the gastrointestinal tract [4]. It is well known that this process strongly depends on individual characteristics such as gender, sports activities, nutrition, stress as well as functional disorders or interactions with other pharmaceuticals [5].…”

Section: Introductionmentioning

confidence: 99%

Dissolution of magnetically marked tablets: Investigations in a physical phantom

Biller

Domey

Fiedler

et al. 2012

2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Pharmacological research is strongly driven by maximizing the bioavailability of new pharmaceuticals. For orally applied drugs the bioavailability highly depends on the process of dissolution in the gastrointestinal tract and is affected by numerous physiological and environmental factors. Available techniques for in vivo monitoring of the dissolution process are very limited and not applicable for large studies. The technique of magnetic marker monitoring provides new prospects for these investigations. However, it is currently limited due to low fields common magnetic markers produce. Hence, only highly sensitive sensors are applicable. In this paper, we performed dissolution tests of novel markers in a physical phantom with magnetoresistive sensors in an unshielded environment. The markers were continuously localized and the movement through the phantom was tracked. By analyzing the changing magnetic moment of the markers we were able to monitor the progress of dissolution in the phantom. We conclude that our proposed phantom and tracking technique is an important step towards new systems for in vivo monitoring of pharmaceutical dissolution processes.

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A novel double-coating approach for improved pH-triggered delivery to the ileo-colonic region of the gastrointestinal tract

Cited by 42 publications

References 20 publications

Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements

Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements

Eudragit L/HPMCAS Blend Enteric-Coated Lansoprazole Pellets: Enhanced Drug Stability and Oral Bioavailability

Dissolution of magnetically marked tablets: Investigations in a physical phantom

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