A novel, dual action chimera comprising DNA methylating agent and near-IR xanthene-cyanine photosensitizer for combined anticancer therapy

Thankarajan, Ebaston; Walunj, Dipak; Bazylevich, Andrii; Prasad, Chandrashekhar; Hesin, Arkadi; Patsenker, L. D.; Gellerman, Gary

doi:10.1016/j.pdpdt.2022.102722

Cited by 2 publications

(2 citation statements)

References 49 publications

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“…Among those mentioned above, indolenine and benz[ e ]indole derivatives are the most highlighted in the recent literature. Furthermore, anthracene units serving as heterocyclic units have been reported [ 244 , 245 ]. The nature of the heterocycles may condition the biological activity of cyanines, varying, for example, the stability of dyes to light [ 246 ]; Central ring: The introduction of cyclic structures in the center of cyanines is a strategy that allows for improving the rigidity and chemical stability of this class of molecules.…”

Section: N -Heterocyclic-bearing Dyes As Photodynamic Therap...mentioning

confidence: 99%

Section: N -Heterocyclic-bearing Dyes As Photodynamic Therap...mentioning

confidence: 99%

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Photodynamic Therapy: From the Basics to the Current Progress of N-Heterocyclic-Bearing Dyes as Effective Photosensitizers

Lima

Reis

2023

Molecules

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Photodynamic therapy, an alternative that has gained weight and popularity compared to current conventional therapies in the treatment of cancer, is a minimally invasive therapeutic strategy that generally results from the simultaneous action of three factors: a molecule with high sensitivity to light, the photosensitizer, molecular oxygen in the triplet state, and light energy. There is much to be said about each of these three elements; however, the efficacy of the photosensitizer is the most determining factor for the success of this therapeutic modality. Porphyrins, chlorins, phthalocyanines, boron-dipyrromethenes, and cyanines are some of the N-heterocycle-bearing dyes’ classes with high biological promise. In this review, a concise approach is taken to these and other families of potential photosensitizers and the molecular modifications that have recently appeared in the literature within the scope of their photodynamic application, as well as how these compounds and their formulations may eventually overcome the deficiencies of the molecules currently clinically used and revolutionize the therapies to eradicate or delay the growth of tumor cells.

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Section: N -Heterocyclic-bearing Dyes As Photodynamic Therap...mentioning

confidence: 99%

Section: N -Heterocyclic-bearing Dyes As Photodynamic Therap...mentioning

confidence: 99%

Photodynamic Therapy: From the Basics to the Current Progress of N-Heterocyclic-Bearing Dyes as Effective Photosensitizers

Lima

Reis

2023

Molecules

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Cyanine dyes in the mitochondria-targeting photodynamic and photothermal therapy

Kejík,

Hajduch,

Abramenko

et al. 2024

Commun Chem

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Mitochondrial dysregulation plays a significant role in the carcinogenesis. On the other hand, its destabilization strongly represses the viability and metastatic potential of cancer cells. Photodynamic and photothermal therapies (PDT and PTT) target mitochondria effectively, providing innovative and non-invasive anticancer therapeutic modalities. Cyanine dyes, with strong mitochondrial selectivity, show significant potential in enhancing PDT and PTT. The potential and limitations of cyanine dyes for mitochondrial PDT and PTT are discussed, along with their applications in combination therapies, theranostic techniques, and optimal delivery systems. Additionally, novel approaches for sonodynamic therapy using photoactive cyanine dyes are presented, highlighting advances in cancer treatment.

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A novel, dual action chimera comprising DNA methylating agent and near-IR xanthene-cyanine photosensitizer for combined anticancer therapy

Cited by 2 publications

References 49 publications

Photodynamic Therapy: From the Basics to the Current Progress of N-Heterocyclic-Bearing Dyes as Effective Photosensitizers

Photodynamic Therapy: From the Basics to the Current Progress of N-Heterocyclic-Bearing Dyes as Effective Photosensitizers

Cyanine dyes in the mitochondria-targeting photodynamic and photothermal therapy

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