A novel electrochemical platform based on mesoporous silica/titania and gold nanoparticles for simultaneous determination of norepinephrine and dopamine

Morawski, Franciele de Matos; Xavier, Brenda Borges; Virgili, Anike H.; Caetano, Karine dos Santos; Menezes, Eliana Weber de; Benvenutti, Edílson V.; Costa, Tânia Maria Haas; Arenas, Leliz Ticona

doi:10.1016/j.msec.2020.111646

Cited by 32 publications

(15 citation statements)

References 42 publications

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“…It was reported that surface modification of SiTi material with AuNPs led to a significant improvement in low charge transfer resistance and redox peak current. The LODs were 0.35 µmol L −1 and 0.57 µmol L −1 for norepinephrine and dopamine, respectively [93].…”

Section: Metal Np-based Sensorsmentioning

confidence: 98%

Amino Acids, Peptides, and Proteins: Implications for Nanotechnological Applications in Biosensing and Drug/Gene Delivery

Laraib

Arshad

et al. 2021

Nanomaterials

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Over various scientific fields in biochemistry, amino acids have been highlighted in research works. Protein, peptide- and amino acid-based drug delivery systems have proficiently transformed nanotechnology via immense flexibility in their features for attaching various drug molecules and biodegradable polymers. In this regard, novel nanostructures including carbon nanotubes, electrospun carbon nanofibers, gold nanoislands, and metal-based nanoparticles have been introduced as nanosensors for accurate detection of these organic compounds. These nanostructures can bind the biological receptor to the sensor surface and increase the surface area of the working electrode, significantly enhancing the biosensor performance. Interestingly, protein-based nanocarriers have also emerged as useful drug and gene delivery platforms. This is important since, despite recent advancements, there are still biological barriers and other obstacles limiting gene and drug delivery efficacy. Currently available strategies for gene therapy are not cost-effective, and they do not deliver the genetic cargo effectively to target sites. With rapid advancements in nanotechnology, novel gene delivery systems are introduced as nonviral vectors such as protein, peptide, and amino acid-based nanostructures. These nano-based delivery platforms can be tailored into functional transformation using proteins and peptides ligands based nanocarriers, usually overexpressed in the specified diseases. The purpose of this review is to shed light on traditional and nanotechnology-based methods to detect amino acids, peptides, and proteins. Furthermore, new insights into the potential of amino protein-based nanoassemblies for targeted drug delivery or gene transfer are presented.

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Section: Metal Np-based Sensorsmentioning

confidence: 98%

Amino Acids, Peptides, and Proteins: Implications for Nanotechnological Applications in Biosensing and Drug/Gene Delivery

Laraib

Arshad

et al. 2021

Nanomaterials

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“…The performance characteristics of other recently reported electrochemical sensors for DA detection are summarized in Table I (73)(74)(75)(76)(77)(78)(79)(80)(81)(82)(83)(84)(85)(86)(87)(88)(89)(90).…”

Section: Elect Rochemical Sensors For Dopa Mine Analysismentioning

confidence: 99%

Actualities in immunological markers and electrochemical sensors for determination of dopamine and its metabolites in psychotic disorders (Review)

et al. 2021

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Psychotic disorders represent a serious health concern. At this moment, anamnestic data, international criteria for diagnosis/classification from the Diagnostic and Statistical Manual of Mental Disorders-5 and the International Classification of Diseases-10 and diagnostic scales are used to establish a diagnosis. The most commonly used biomarkers in psychotic illnesses are those regarding the neuroimmune system, metabolic abnormalities, neurotrophins and neurotransmitter systems and proteomics. A current issue faced by clinicians is the lack of biomarkers to help develop a more accurate diagnosis, with the possibility of initiating the most effective treatment. The detection of biological markers for psychosis has the potential to contribute to improvements in its diagnosis, prognosis and treatment effectiveness. The mixture of multiple biomarkers may improve the ability to differentiate and classify these patients. In this sense, the aim of this study was to analyze the literature concerning the potential biomarkers that could be used in medical practice and to review the newest developments in electrochemical sensors used for dopamine detection, one of the most important exploited biomarkers.

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“…d DPVs of Fe 3 O 4 @ppy-Pt/SPE in 0.1 M PBS with a pH of 7, and consisting of distinct concentrations of 6-mercaptopurine [ 13 ]. e SWV of SiTi/AuNP/CPE with sequential additions of norepinephrine [ 14 ]. f SWV of SiTi/AuNP/CPE with sequential additions of dopamine in the presence of 1 μmol of norepinephrine [ 14 ] …”

Section: Introductionmentioning

confidence: 99%

“…e SWV of SiTi/AuNP/CPE with sequential additions of norepinephrine [ 14 ]. f SWV of SiTi/AuNP/CPE with sequential additions of dopamine in the presence of 1 μmol of norepinephrine [ 14 ] …”

Section: Introductionmentioning

confidence: 99%

Point-of-care biochemical assays using electrochemical technologies: approaches, applications, and opportunities

et al. 2022

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Against the backdrop of hidden symptoms of diseases and limited medical resources of their investigation, in vitro diagnosis has become a popular mode of real-time healthcare monitoring. Electrochemical biosensors have considerable potential for use in wearable products since they can consistently monitor the physiological information of the patient. This review classifies and briefly compares commonly available electrochemical biosensors and the techniques of detection used. Following this, the authors focus on recent studies and applications of various types of sensors based on a variety of methods to detect common compounds and cancer biomarkers in humans. The primary gaps in research are discussed and strategies for improvement are proposed along the dimensions of hardware and software. The work here provides new guidelines for advanced research on and a wider scope of applications of electrochemical biosensors to in vitro diagnosis. Graphical abstract

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A novel electrochemical platform based on mesoporous silica/titania and gold nanoparticles for simultaneous determination of norepinephrine and dopamine

Cited by 32 publications

References 42 publications

Amino Acids, Peptides, and Proteins: Implications for Nanotechnological Applications in Biosensing and Drug/Gene Delivery

Amino Acids, Peptides, and Proteins: Implications for Nanotechnological Applications in Biosensing and Drug/Gene Delivery

Actualities in immunological markers and electrochemical sensors for determination of dopamine and its metabolites in psychotic disorders (Review)

Point-of-care biochemical assays using electrochemical technologies: approaches, applications, and opportunities

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