A novel electrochemical sensor for the detection of oxidative stress and cancer biomarker (4-nitroquinoline N-oxide) based on iron nitride nanoparticles with multilayer reduced graphene nanosheets modified electrode

Rajaji, Umamaheswari; Muthumariyappan, Akilarasan; Chen, Shen‐Ming; Ramalingam, R. Jothi

doi:10.1016/j.snb.2019.04.041

Cited by 35 publications

(14 citation statements)

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“…Reduced graphene oxide sheets were decorated with iron nitride nanoparticles (Fe 2 N) NPs produced by a solvothermal method and followed by a nitridation process [665]. The nanocomposite was screen printed to fabricate electrodes possessing high electrochemical sensing properties toward 4-nitroquinoline N-oxide (4-NQO) an important cancer marker.…”

Section: Figure 38mentioning

confidence: 99%

Carbon Nanomaterials: Synthesis, Functionalization and Sensing Applications

Speranza

2021

Nanomaterials

211

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Recent advances in nanomaterial design and synthesis has resulted in robust sensing systems that display superior analytical performance. The use of nanomaterials within sensors has accelerated new routes and opportunities for the detection of analytes or target molecules. Among others, carbon-based sensors have reported biocompatibility, better sensitivity, better selectivity and lower limits of detection to reveal a wide range of organic and inorganic molecules. Carbon nanomaterials are among the most extensively studied materials because of their unique properties spanning from the high specific surface area, high carrier mobility, high electrical conductivity, flexibility, and optical transparency fostering their use in sensing applications. In this paper, a comprehensive review has been made to cover recent developments in the field of carbon-based nanomaterials for sensing applications. The review describes nanomaterials like fullerenes, carbon onions, carbon quantum dots, nanodiamonds, carbon nanotubes, and graphene. Synthesis of these nanostructures has been discussed along with their functionalization methods. The recent application of all these nanomaterials in sensing applications has been highlighted for the principal applicative field and the future prospects and possibilities have been outlined.

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Section: Figure 38mentioning

confidence: 99%

Carbon Nanomaterials: Synthesis, Functionalization and Sensing Applications

Speranza

2021

Nanomaterials

211

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“…29,30 Additionally, our dual-MIP device detects 4-NQO with the highest performance when compared with the nanomaterial-modified electrodes zinc ferrite nanocubes (ZnFe 2 O 4 ), 25 iron nitride nanoparticles (Fe 2 N), 10 bismuth tungstate nanospheres (Bi 2 WO 6 ) 9 decorating reduced graphene oxide (rGO) nanocomposite modified on a glassy carbon electrode (GCE), 9,25 and screen-printed carbon electrode (SPCE). 10 Our results suggest that the new GQDs-AuNPs@dual-MIP sphere is important in enhancing the electrochemical activity. Our as-prepared nanosphere provides the synergistic effects of the excellent electrocatalytic activity of the GQDs-AuNPs core, combined with the specific properties of MIP.…”

Section: Analyticalmentioning

confidence: 99%

“…Among the ePAD, the 3-NT detection range of our dual-MIPs (0.01−500 μM) is comparable to SiO 2 @AgNPs@MIP-modified SPGE 31 and broader than previously reported. 29,30 Additionally, our dual-MIP device detects 4-NQO with the highest performance when compared with the nanomaterial-modified electrodes zinc ferrite nanocubes (ZnFe 2 O 4 ), 25 iron nitride nanoparticles (Fe 2 N), 10 bismuth tungstate nanospheres (Bi 2 WO 6 ) 9 decorating reduced graphene oxide (rGO) nanocomposite modified on a glassy carbon electrode (GCE), 9,25 and screen-printed carbon electrode (SPCE). 10 Our results suggest that the new GQDs-AuNPs@dual-MIP sphere is important in enhancing the electrochemical activity.…”

Section: Analyticalmentioning

confidence: 99%

“…Furthermore, the development of ready-to-use 4-NQO sensors using screen-printed electrodes (SPE) modified with iron nitride nanoparticles decorated on rGO (Fe 2 N NPs@rGO) has been successful. 10 Additionally, an electrochemical paperbased analytical device (ePAD) is preferred to overcome the challenging and critical issues for point-of-care (POC) analysis because it is a simple-to-fabricate, cost-effective, durable, readyto-use sensor that can be readily modified or enhanced by antiinterferent abilities. A facile ePAD for detecting 3-NT has been developed by screen-printing an electrode with carbon ink.…”

Section: ■ Introductionmentioning

confidence: 99%

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Facile and Compact Electrochemical Paper-Based Analytical Device for Point-of-Care Diagnostic of Dual Carcinogen Oxidative Stress Biomarkers through a Molecularly Imprinted Polymer Coated on Graphene Quantum-Dot Capped Gold

et al. 2022

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Nanoscale imprinting significantly increases the specific surface area and recognition capabilities of a molecularly imprinted polymer by improving accessibility to analytes, binding kinetics, and template removal. Herein, we present a novel synthetic route for a dual molecularly imprinted polymer (dual-MIP) of the carcinogen oxidative stress biomarkers 3-nitrotyrosine (3-NT) and 4-nitroquinolin-N-oxide (4-NQO) as coatings on graphene quantum-dot capped gold nanoparticles (GQDs-AuNPs). The dual-MIP was successfully coated on the GQDs-AuNPs core via a (3-mercaptopropyl) trimethoxysilane (MPTMS) linkage and copolymerization with the 3-aminopropyltriethoxysilane (APTMS) functional monomer. In addition, we fabricated a facile and compact three-dimensional electrochemical paper-based analytical device (3D-ePAD) for the simultaneous determination of the dual biomarkers using a GQDs-AuNPs@dual-MIP-modified graphene electrode (GQDs-AuNPs@dual-MIP/SPGE). The developed dual-MIP device provides greatly enhanced electrochemical signal amplification due to the improved electrode-specific surface area, electrocatalytic activity, and the inclusion of large numbers of dual-imprinted sites for 3-NT and 4-NQO detection. Quantitative analysis used square wave voltammetry, with an oxidation current appearing at −0.10 V for 4-NQO and +0.78 V for 3-NT. The dual-MIP sensor revealed excellent linear dynamic ranges of 0.01 to 500 μM for 3-NT and 0.005 to 250 μM for 4-NQO, with detection limits in nanomolar levels for both biomarkers. Furthermore, the dual-MIP sensor for the simultaneous determination of 3-NT and 4-NQO provides high accuracy and precision, with no evidence of interference from urine, serum, or whole blood samples.

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“…The term oxidative stress is defined to be the imbalance or the excessive production of reactive oxygen species (ROS) in cellular metabolism [18,19]. It plays an important role in living organisms such as maintenance of cell growth and production of important biologic substances, etc.…”

Section: Introductionmentioning

confidence: 99%

An Ultra-Sensitive Electrochemical Sensor for the Detection of Carcinogen Oxidative Stress 4-Nitroquinoline N-Oxide in Biologic Matrices Based on Hierarchical Spinel Structured NiCo2O4 and NiCo2S4; A Comparative Study

Chen

Tamilalagan

Akilarasan

et al. 2020

IJMS

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Various factors leads to cancer; among them oxidative damage is believed to play an important role. Moreover, it is important to identify a method to detect the oxidative damage. Recently, electrochemical sensors have been considered as the one of the most important techniques to detect DNA damage, owing to its rapid detection. However, electrode materials play an important role in the properties of electrochemical sensor. Currently, researchers have aimed to develop novel electrode materials for low-level detection of biomarkers. Herein, we report the facile hydrothermal synthesis of NiCo2O4 micro flowers (MFs) and NiCo2S4 micro spheres (Ms) and evaluate their electrochemical properties for the detection of carcinogen-causing biomarker 4-nitroquinoline n-oxide (4-NQO) in human blood serum and saliva samples. Moreover, as-prepared composites were fabricated on a glass carbon electrode (GCE), and its electrochemical activities for the determination of 4-NQO were investigated by using various electrochemical techniques. Fascinatingly, the NiCo2S4-Ms showed a very low detection limit of 2.29 nM and a wider range of 0.005 to 596.64 µM for detecting 4-NQO. Finally, the practical applicability of NiCo2S4-Ms in the 4-NQO spiked human blood serum and saliva samples were also investigated.

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A novel electrochemical sensor for the detection of oxidative stress and cancer biomarker (4-nitroquinoline N-oxide) based on iron nitride nanoparticles with multilayer reduced graphene nanosheets modified electrode

Cited by 35 publications

References 50 publications

Carbon Nanomaterials: Synthesis, Functionalization and Sensing Applications

Carbon Nanomaterials: Synthesis, Functionalization and Sensing Applications

Facile and Compact Electrochemical Paper-Based Analytical Device for Point-of-Care Diagnostic of Dual Carcinogen Oxidative Stress Biomarkers through a Molecularly Imprinted Polymer Coated on Graphene Quantum-Dot Capped Gold

An Ultra-Sensitive Electrochemical Sensor for the Detection of Carcinogen Oxidative Stress 4-Nitroquinoline N-Oxide in Biologic Matrices Based on Hierarchical Spinel Structured NiCo2O4 and NiCo2S4; A Comparative Study

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