A novel electrochemical sensor for determination of uric acid in the presence of ascorbic acid and dopamine based on a carbon paste electrode modified with an electrochemically reduced <i>para</i>-nitrobenzoic acid/graphene oxide nanocomposite

Hadi, Z.; Ghanbari, Kh.

doi:10.1039/d2nj01358d

Cited by 11 publications

(5 citation statements)

References 48 publications

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“…The ZnO NR-CuO NS/GC sensor showed 0.5 μM (S/N = 3) limit of detection. Table shows a comparative sensing performance of different sensors, where we can see that our fabricated sensor showed better sensing performance. ,,− Such boosted sensing performance could be attributed to the ZnO NR-CuO NS hybrid nanostructure, where electro-active sites may be present in abundance. However, the enzymeless UA catalysis over the working electrode surface having nanomaterials is not well reported in the literature.…”

Section: Results and Discussionmentioning

confidence: 91%

Electrochemical Sensing of Uric Acid with Zinc Oxide Nanorods Decorated with Copper Oxide Nanoseeds

Masrat,

Nagal,

Khan

et al. 2023

ACS Appl. Nano Mater.

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The use of hybrid nanostructured nanomaterials in sensor development has the potential to overcome the sensitivity issue due to the combination of different nanoscale features of the desired nanomaterials that are accumulated together and offer entirely different characteristics. The sensitive quantification of biomolecules is required for early disease diagnosis. Herein, a hybrid (zinc oxide nanorods modified with copper oxide nanoseeds (ZnO NRs-CuO NSs)) nanostructured nanomaterial-integrated sensor that detects uric acid (UA) is reported. A low-temperature solution-based method was described for ZnO NR and ZnO NR-CuO NS hybrid nanomaterial syntheses. The use of the ZnO NR-CuO NS hybrid nanomaterial resulted in ultra-high sensitivity (1477.88 μA/mM cm 2 ) toward UA detection using the differential pulse voltammetry (DPV) technique. DPV resulted in ∼7.7 times better sensitivity compared to cyclic voltammetry (CV)-measured sensitivity (187.32 μA/mM cm 2 ). The surface modification of ZnO NRs with CuO NS "hybrid nanostructures" showed a significant impact and synergistic effect that enhanced the sensing performance. Furthermore, selectivity, stability, fabrication reproducibility, and applicability in the real sample are other crucial factors of this ZnO NR-CuO NS hybrid nanomaterial-based UA sensor.

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Section: Results and Discussionmentioning

confidence: 91%

Electrochemical Sensing of Uric Acid with Zinc Oxide Nanorods Decorated with Copper Oxide Nanoseeds

Masrat,

Nagal,

Khan

et al. 2023

ACS Appl. Nano Mater.

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“…Nitrobenzoic acid and its derivatives are essential materials in pharmaceutical industries [ 14 , 15 , 16 ]. A literature study revealed a good deal of work on the properties of NBA and its substituted derivatives [ 17 ].…”

Section: Nitrobenzoic Acid (Nba)mentioning

confidence: 99%

Biological Activity of Complexes Involving Nitro-Containing Ligands and Crystallographic-Theoretical Description of 3,5-DNB Complexes

Fonseca-López,

Lozano,

Macías

et al. 2024

IJMS

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Drug resistance in infectious diseases developed by bacteria and fungi is an important issue since it is necessary to further develop novel compounds with biological activity that counteract this problem. In addition, new pharmaceutical compounds with lower secondary effects to treat cancer are needed. Coordination compounds appear to be accessible and promising alternatives aiming to overcome these problems. In this review, we summarize the recent literature on coordination compounds based on nitrobenzoic acid (NBA) as a ligand, its derivatives, and other nitro-containing ligands, which are widely employed owing to their versatility. Additionally, an analysis of crystallographic data is presented, unraveling the coordination preferences and the most effective crystallization methods to grow crystals of good quality. This underscores the significance of elucidating crystalline structures and utilizing computational calculations to deepen the comprehension of the electronic properties of coordination complexes.

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“…On the other hand, electrochemical-based sensors have the potential for rapid detection and offer high-sensing performance during biomolecules detection [ 8 , 9 , 10 , 12 , 13 , 14 ]. Recently, considerable attention has been given to electrochemical-based UA sensors due to their high selectivity, accuracy, less interference, and low-cost [ 15 , 16 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…There are two types of electrodes (i.e., metal-based and carbon-based electrodes) that are mostly used in electrochemical sensor fabrication. The carbon-based electrodes (i.e., glassy carbon, screen-printed, and carbon-paste electrodes) are the preferred working electrodes due to the minimum over potential requirement compared to the metal-based electrodes [ 19 ]. Due to their low costs and ease of preparation, the carbon-based electrodes have been extensively used in electrochemical sensing applications.…”

Section: Introductionmentioning

confidence: 99%

“…The improved electro-catalytic activity and charge transfer capabilities of metal/metal oxide have attracted considerable interest for their applications in electrode modifications [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. Among different metal oxides, cobalt oxide nanomaterials have been utilized to fabricate enzymatic/non-enzymatic sensors where the use of cobalt oxide nanostructures enhances the desired electrochemical properties [ 23 , 24 , 25 , 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

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Electrochemical Ultrasensitive Sensing of Uric Acid on Non-Enzymatic Porous Cobalt Oxide Nanosheets-Based Sensor

et al. 2022

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Transition metal oxide (TMO)-based nanomaterials are effectively utilized to fabricate clinically useful ultra-sensitive sensors. Different nanostructured nanomaterials of TMO have attracted a lot of interest from researchers for diverse applications. Herein, we utilized a hydrothermal method to develop porous nanosheets of cobalt oxide. This synthesis method is simple and low temperature-based. The morphology of the porous nanosheets like cobalt oxide was investigated in detail using FESEM and TEM. The morphological investigation confirmed the successful formation of the porous nanosheet-like nanostructure. The crystal characteristic of porous cobalt oxide nanosheets was evaluated by XRD analysis, which confirmed the crystallinity of as-synthesized cobalt oxide nanosheets. The uric acid sensor fabrication involves the fixing of porous cobalt oxide nanosheets onto the GCE (glassy carbon electrode). The non-enzymatic electrochemical sensing was measured using CV and DPV analysis. The application of DPV technique during electrochemical testing for uric acid resulted in ultra-high sensitivity (3566.5 µAmM−1cm−2), which is ~7.58 times better than CV-based sensitivity (470.4 µAmM−1cm−2). Additionally, uric acid sensors were tested for their selectivity and storage ability. The applicability of the uric acid sensors was tested in the serum sample through standard addition and recovery of known uric acid concentration. This ultrasensitive nature of porous cobalt oxide nanosheets could be utilized to realize the sensing of other biomolecules.

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A novel electrochemical sensor for determination of uric acid in the presence of ascorbic acid and dopamine based on a carbon paste electrode modified with an electrochemically reduced para-nitrobenzoic acid/graphene oxide nanocomposite

Abstract: In this study, a highly sensitive electrochemical sensor based on a carbon paste electrode was modified by an electrochemically reduced para-nitrobenzoic acid/graphene oxide nanocomposite to measure uric acid.

Cited by 11 publications

References 48 publications

Electrochemical Sensing of Uric Acid with Zinc Oxide Nanorods Decorated with Copper Oxide Nanoseeds

Electrochemical Sensing of Uric Acid with Zinc Oxide Nanorods Decorated with Copper Oxide Nanoseeds

Biological Activity of Complexes Involving Nitro-Containing Ligands and Crystallographic-Theoretical Description of 3,5-DNB Complexes

Electrochemical Ultrasensitive Sensing of Uric Acid on Non-Enzymatic Porous Cobalt Oxide Nanosheets-Based Sensor

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