A novel experimental approach to evaluate guided bone regeneration (GBR) in the rat femur using a 3D-printed CAD/CAM zirconia space-maintaining barrier

Abstract

Graphical abstract

Chemical Composition and Flexural Strength Discrepancies Between Milled and Lithography‐Based Additively Manufactured Zirconia

“…Currently, subtractive manufacturing methods are considered the gold standard for fabricating zirconia dental restorations, but AM technologies are in continuous development. Limited dental literature has assessed the potential of AM zirconia for prosthodontic dental applications 6–17 . Among the different AM technologies available to process zirconia material, vat‐polymerized AM zirconia including stereolithography (SLA), digital light processing (DLP), and lithography‐based ceramic manufacturing (LCM) methods are frequently selected in the dental field 6–11,13,15–17 …”

“…Limited dental literature has assessed the potential of AM zirconia for prosthodontic dental applications. [6][7][8][9][10][11][12][13][14][15][16][17] Among the different AM technologies available to process zirconia material, vatpolymerized AM zirconia including stereolithography (SLA), digital light processing (DLP), and lithography-based ceramic…”

Three-Dimensional Zirconia-Based Scaffolds for Load-Bearing Bone-Regeneration Applications: Prospects and Challenges

“…Even though the authors mimicked the bone implantation of the zirconia scaffolds via tribological tests, it is essential to verify the cell activity of the scaffolds in the biological environment. To all the above, most recently, Tetre et al, revealed a unique method for evaluating bone reconstruction using zirconia scaffolds in the rat femur via a 3D-CAD/CAM approach [70]. A thorough illustration of the design and milling of 3D-tailored CAD/CAM zirconia space-maintaining strategies for a rat femur is presented in Figure 5b.…”

Incorporation of Magnesium and Zinc Metallic Particles in PLGA Bi-layered Membranes with Sequential Ion Release for Guided Bone Regeneration

“…The resorbable collagen membrane is considered the standard reference for GBR because of its good biocompatibility and biodegradability . However, the insufficient mechanical properties and fast degradation induced by proteases limit their clinical application, especially for vertical augmentation . In addition, almost all membrane products only act as a passive barrier, lacking bioactive functions, such as osteogenesis and anti-infection.…”

“…7 However, the insufficient mechanical proper-ties and fast degradation induced by proteases limit their clinical application, especially for vertical augmentation. 8 In addition, almost all membrane products only act as a passive barrier, lacking bioactive functions, such as osteogenesis and anti-infection. In this perspective, the need to engineer active barrier membranes which can favor osteogenesis in the underlying defect during GBR, protect the wound from the penetration of bacteria, and exhibit favorable mechanical behaviors is still ongoing.…”