A Novel Flavonoid Composition Targets Androgen Receptor Signaling and Inhibits Prostate Cancer Growth in Preclinical Models

Mamouni, Kenza; Zhang, Shumin; Li, Xin; Chen, Yanhua; Yang, Yang; Kim, Jaeah; Bartlett, Michael G.; Coleman, Ilsa M.; Nelson, Peter S.; Küçük, Ömer; Wu, Daqing

doi:10.1016/j.neo.2018.06.003

Cited by 28 publications

(22 citation statements)

References 48 publications

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“…Kaempferol has been shown to induce GM-CSF release in PC-3 cells that, in turn, increase the chemotaxis of DC through activation of phospholipase C (PLC), MEK1/2, and protein kinase C (PKC) [73]. Obviously, the transcriptome of prostate cancers cells is also markedly affected by kaempferol treatment as evidenced by the down-regulation of androgen receptor genes expression [74]. In rats, orally administered kaempferol showed no significant toxicity and significantly increased survival, in addition to reducing the growth of PCa xenografts in athymic nude mice [74].…”

Section: Anticancer Properties Of Kaempferolmentioning

confidence: 99%

Kaempferol: A Key Emphasis to Its Anticancer Potential

et al. 2019

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A marked decrease in human cancers, including breast cancer, bone cancer, and cervical cancer, has been linked to the consumption of vegetable and fruit, and the corresponding chemoprotective effect has been associated with the presence of several active molecules, such as kaempferol. Kaempferol is a major flavonoid aglycone found in many natural products, such as beans, bee pollen, broccoli, cabbage, capers, cauliflower, chia seeds, chives, cumin, moringa leaves, endive, fennel, and garlic. Kaempferol displays several pharmacological properties, among them antimicrobial, anti-inflammatory, antioxidant, antitumor, cardioprotective, neuroprotective, and antidiabetic activities, and is being applied in cancer chemotherapy. Specifically, kaempferol-rich food has been linked to a decrease in the risk of developing some types of cancers, including skin, liver, and colon. The mechanisms of action include apoptosis, cell cycle arrest at the G2/M phase, downregulation of epithelial-mesenchymal transition (EMT)-related markers, and phosphoinositide 3-kinase/protein kinase B signaling pathways. In this sense, this article reviews data from experimental studies that investigated the links between kaempferol and kaempferol-rich food intake and cancer prevention. Even though growing evidence supports the use of kaempferol for cancer prevention, further preclinical and clinical investigations using kaempferol or kaempferol-rich foods are of pivotal importance before any public health recommendation or formulation using kaempferol.

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Section: Anticancer Properties Of Kaempferolmentioning

confidence: 99%

Kaempferol: A Key Emphasis to Its Anticancer Potential

et al. 2019

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“…Increased mouse survival [339,[352][353][354][355]. Reduced tumor growth and metastasis [339,[352][353][354][355][356]. Caused degranulation and accumulation of mediators in leukemia cells [357,358].…”

Section: Kaempferolmentioning

confidence: 99%

“…Studies investigating the anti-cancer effects of kaempferol in vivo were also reviewed by Irman et al [328,423]. In in vivo mouse models of various cancers, including bladder, oral, prostate, lung and bone cancers, treatment with kaempferol was able to increase survival and reduce the growth and metastasis of tumours [339,[352][353][354][355]. In a rat model of leukemia, treatment with kaempferol resulted in degranulation in basophilic leukemia cells (RBL-2H3) and increased the accumulation of mediators in human leukemic mast cells (HMC-1) [357,358].…”

Section: Kaempferolmentioning

confidence: 99%

Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Tomko

Whynot

Ellis

et al. 2020

Cancers

160

139

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In recent years, and even more since its legalization in several jurisdictions, cannabis and the endocannabinoid system have received an increasing amount of interest related to their potential exploitation in clinical settings. Cannabinoids have been suggested and shown to be effective in the treatment of various conditions. In cancer, the endocannabinoid system is altered in numerous types of tumours and can relate to cancer prognosis and disease outcome. Additionally, cannabinoids display anticancer effects in several models by suppressing the proliferation, migration and/or invasion of cancer cells, as well as tumour angiogenesis. However, the therapeutic use of cannabinoids is currently limited to the treatment of symptoms and pain associated with chemotherapy, while their potential use as cytotoxic drugs in chemotherapy still requires validation in patients. Along with cannabinoids, cannabis contains several other compounds that have also been shown to exert anti-tumorigenic actions. The potential anti-cancer effects of cannabinoids, terpenes and flavonoids, present in cannabis, are explored in this literature review.

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“…Likewise, sulforaphane (an isothiocyanate) was found to downregulate the TMPRSS2 expression through the release and translocation of the Nrf2 (nuclear factor (erythroid-derived 2)-like 2) (Gibbs et al, 2009;Meyer and Jaspers, 2015). Mamouni et al (2018) found that a standardized flavonoids formulation including luteolin, quercetin, and kaempferol significantly suppressed TMPRSS2 expression. In spite of the diverse biological effects attributed to the three flavonoids, this study has demonstrated that at low concentrations, they exhibited an important synergic effect.…”

Section: Natural Products Targeting the Tmprss2mentioning

confidence: 99%

Medicinal Plants as Sources of Active Molecules Against COVID-19

2020

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The Severe Acute Respiratory Syndrome-related Coronavirus 2 (SARS-CoV-2) or novel coronavirus (COVID-19) infection has been declared world pandemic causing a worrisome number of deaths, especially among vulnerable citizens, in 209 countries around the world. Although several therapeutic molecules are being tested, no effective vaccines or specific treatments have been developed. Since the COVID-19 outbreak, different traditional herbal medicines with promising results have been used alone or in combination with conventional drugs to treat infected patients. Here, we review the recent findings regarding the use of natural products to prevent or treat COVID-19 infection. Furthermore, the mechanisms responsible for this preventive or therapeutic effect are discussed. We conducted literature research using PubMed, Google Scholar, Scopus, and WHO website. Dissertations and theses were not considered. Only the situation reports edited by the WHO were included. The different herbal products (extracts) and purified molecules may exert their anti-SARS-CoV-2 actions by direct inhibition of the virus replication or entry. Interestingly, some products may block the ACE-2 receptor or the serine protease TMPRRS2 required by SARS-CoV-2 to infect human cells. In addition, natural products were shown to inhibit the SARS-CoV-2 life-cycle related proteins such as papain-like or chymotrypsin-like proteases. In conclusion, we suggest that natural products could be used alone or in combination as alternative medicines to treat/ prevent COVID-19 infection. Moreover, their structures may offer clues for the development of anti-SARS-CoV-2 drugs.

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A Novel Flavonoid Composition Targets Androgen Receptor Signaling and Inhibits Prostate Cancer Growth in Preclinical Models

Cited by 28 publications

References 48 publications

Kaempferol: A Key Emphasis to Its Anticancer Potential

Kaempferol: A Key Emphasis to Its Anticancer Potential

Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis

Medicinal Plants as Sources of Active Molecules Against COVID-19

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