A novel flow‐injection chemiluminescence method for determination of andrographolide in andrographis tablets

Abstract

A novel method for determination of andrographolide using flow-injection chemiluminescence (FI-CL) analysis is described in this paper. The chemiluminescence intensity of the solution was enhanced proportionally while the concentration of andrographolide increased. Under the selected experimental conditions, the calibration curve of andrographolide was linear within the range of 0.2 to 35.0 µg mL(-1) with a linear equation of ΔI = 23.391x (µg mL(-1)) + 34.191, R(2) = 0.9965. The detection limit (3σ) was 7.42 × 10(-2) µg mL(-1). At the case of continuous determination of andrographolide, the relative standard deviation (RSD, n =11) was less than 1.82%. The method has been successfully applied to the determination of andrographis tablets with satisfactory results.

Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches

“…f.) Wall. ex Nees, can be used to treat cold, fever, sore throat, sore mouth and tongue (Jiang et al, 2013). In recent decades, with the increasing interest in the research of this phytomedicine, abundant of researches has proven that the intervention of modern novel technics to excavate the main effective components from it has become a hot spot (Patil & Jain, 2021; Stopponi et al, 2021).…”

Multiway analysis applied to time‐resolved chemiluminescence for simultaneous determination of paracetamol and codeine in pharmaceuticals

“…However, each of these methods often has its own set of advantages and disadvantages. There are some disadvantages, such as several time‐consuming manipulations, special training or the requirement for comparatively expensive equipment, and some methods are not readily easily made cost‐effective or amenable to miniaturization of the instrumentation . Multiway calibration methods play important roles in solving the problem of closely overlapping peaks.…”

Simultaneous chemiluminescence determination of citric acid and oxalic acid using multi-way partial least squares regression

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