A novel fluorescent probe for the detection of Golgi nitroreductase under hypoxic conditions

Abstract

The first golgi-targeted fluorescent probe (named as Gol-NTR) for detecting nitroreductase (NTR) was developed. Gol-NTR had good selectivity for NTR and low cytotoxicity. Furthermore, it is worth noting that Gol-NTR...

Fluorescent probes for targeting the Golgi apparatus: design strategies and applications

“…Using naphthalimide as the fluorescent core and a nitro group as the response group, attached to a Golgi targeting sulfonamide group, the Lin group developed a Golgi-targeting fluorescent probe 20 (Gol-NTR) for detecting nitroreductase (NTR). 74 The probe exhibits high biocompatibility, good photostability, high sensitivity and selectivity for NTR recognition, and was used to detect NTR in the Golgi apparatus. Consequently, the Golgi apparatus state could be monitored under different oxygen levels via the detection of NTR (Fig.…”