A novel green amino acid derivative hydrogel with multi-stimulus responsiveness

Ma, Mingfang; Wang, Tongyu; Liu, Renrui; Jiang, Wenwen; Niu, Zhaocan; Bai, Mingjuan; Wu, Weiwei; Hao, Aiyou; Shang, Wen-Qing

doi:10.1007/s00396-023-05095-0

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…The 1700−1500 cm −1 region was previously assigned to the stretching vibration of amide I and the bending peak of amide II for dipeptides and Fmoc-protected amino acids. 44,55 The stretching vibration band for carbonyl at 1703 cm −1 was redshifted in the presence of metal ions. The band became weak for the ZF/Ca 2+ and ZF/Hg 2+ systems, whereas splitting was observed with trivalent metal ions (Y 3+ , Al 3+ , Ga 3+ , and In 3+ ).…”

mentioning

confidence: 99%

Metal Ion-Induced Unusual Stability of the Metastable Vesicle-like Intermediates Evolving during the Self-Assembly of Phenylalanine: Prominent Role of Surface Charge Inversion

Bagchi,

Maity,

Chakraborty

2024

J. Phys. Chem. Lett.

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The underlying mechanism and intermediate formation in the self-assembly of aromatic amino acids, peptides, and proteins remain elusive despite numerous reports. We, for the first time, report that one can stabilize the intermediates by tuning the metal ion−amino acid interaction. Microscopic and spectroscopic investigations of the self-assembly of carboxybenzyl (Z)-protected phenylalanine (ZF) reveal that the bivalent metal ions eventually lead to the formation of fibrillar networks similar to blank ZF whereas the trivalent ions develop vesicle-like intermediates that do not undergo fibrillation for a prolonged time. The time-lapse measurement of surface charge reveals that the surface charge of blank ZF and in the presence of bivalent metal ions changes from a negative value to zero, implying unstable intermediates leading to the fibril network. Strikingly, a prominent charge inversion from an initial negative value to a positive value in the presence of trivalent metal ions imparts unusual stability to the metastable intermediates.

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mentioning

confidence: 99%

Metal Ion-Induced Unusual Stability of the Metastable Vesicle-like Intermediates Evolving during the Self-Assembly of Phenylalanine: Prominent Role of Surface Charge Inversion

Bagchi,

Maity,

Chakraborty

2024

J. Phys. Chem. Lett.

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show abstract

“…The 1700-1500 cm -1 region was previously assigned to the stretching vibration of amide I and the bending peak of amide II for dipeptides and Fmocprotected amino acids. 47,56 The stretching vibration band for carbonyl at 1703 cm -1 red-shifted in the presence of metal ions. The band became weak for ZF/Ca 2+ and ZF/Hg 2+ , whereas splitting was observed in trivalent metal ions (Y 3+ , Al 3+ , Ga 3+ , In 3+ ).…”

mentioning

confidence: 99%

Metal Ions-Induced Unusual Stability of the Metastable Vesicle-like Intermediates Evolving in the Self-Assembly Process of Phenylalanine: The Role of Hydrophobic Interaction, Metal-Coordination, and Surface Charge Inversion

BAGCHI,

MAITY,

CHAKRABORTY

2024

Preprint

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The underlying mechanism and the intermediates formation in the self-assembly of aromatic amino acids, peptides and proteins remain elusive despite numerous reports. We, for the first time, report that one can modulate the stability of the intermediates by tuning the metal ions-amino acid interaction of carboxybenzyl (Z)-protected phenylalanine (ZF). The microscopic and spectroscopic investigations reveal that the bivalent metal ions lead to the formation of fibrillar networks after a certain interval similar to blank ZF, whereas the trivalent ions develop vesicle-like intermediates which do not undergo fibrillation for a prolonged time. The time-lapse measurement of surface charge reveals that the surface charge of blank ZF and in the presence of bivalent metal ions alters from negative value to zero implying unstable intermediates leading to the fibril network. Strikingly, a prominent charge inversion from an initial negative to a positive value in the presence of trivalent metal ions imparts unusual stability to the metastable intermediates.

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