2022
DOI: 10.1016/j.ejphar.2022.175381
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A novel gut-restricted RIPK1 inhibitor, SZ-15, ameliorates DSS-induced ulcerative colitis

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Cited by 5 publications
(2 citation statements)
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“…The same study found that RIKP1 inhibitors can prevent sustained damage to intestinal tissue caused by inflammatory factors such as TNF-α, IL-1β, IL-22, and IL-6 mRNA while inhibiting cell necroptosis. This may offer a therapeutic option and new hope for UC (Zeng et al, 2022). Additionally, RIPK3 deficiency can alleviate the production of inflammatory factors and ROS in UC mice, providing potential evidence for the use of RIPK3 inhibitors in treating UC disease (Duan et al, 2022).…”
Section: Necroptosismentioning
confidence: 99%
“…The same study found that RIKP1 inhibitors can prevent sustained damage to intestinal tissue caused by inflammatory factors such as TNF-α, IL-1β, IL-22, and IL-6 mRNA while inhibiting cell necroptosis. This may offer a therapeutic option and new hope for UC (Zeng et al, 2022). Additionally, RIPK3 deficiency can alleviate the production of inflammatory factors and ROS in UC mice, providing potential evidence for the use of RIPK3 inhibitors in treating UC disease (Duan et al, 2022).…”
Section: Necroptosismentioning
confidence: 99%
“…Necroptosis, a novel kind of programmed cell death, has been shown to play a pivotal role in a variety of immunological diseases, including inflammatory conditions, 10–12 rheumatoid arthritis (RA), 13 and certain cancers 14 . Characterized by organelle swelling, disruption of cell membrane integrity and the release of intracellular contents, necroptosis is activated by receptor‐interacting protein kinases 1/3 (RIPK1/3) and mixed lineage kinase domain‐like protein (MLKL), with caspase‐8 being a crucial factor in inhibiting this process 15–18 .…”
Section: Introductionmentioning
confidence: 99%