Abstract:Carbon monoxide (CO) gas therapy is a promising cancer treatment. However, gas delivery to the tumor site remains problematic. Proper tunable control of CO release in tumors is crucial to increasing the efficiency of CO treatment and reducing the risk of CO poisoning. To overcome such challenges, we designed ZCM, a novel stable nanotechnology delivery system comprising manganese carbonyl (MnCO) combined with anticancer drug camptothecin (CPT) loaded onto a zeolitic imidazole framework-8 (ZIF-8). After intraven… Show more
“…Keli Zhong et al devised a nanodrug delivery system (DDS) ( Fig. 7 A) for tumor chemotherapy and CO gas therapy [ 104 ]. They encapsulated a manganese carbonyl complex (MnCO) and the anticancer drug camptothecin (CPT) within a zeolite-type MOF (ZIF-8), resulting in the formation of a stable DDS named ZCM.…”
Section: Cornms Based On Hybrid Nanomaterialsmentioning
confidence: 99%
“… Fig. 7 (A) A novel H 2 O 2 -triggered CO release MOF containing CORM and CPT for chemotherapy and gas therapy [ 104 ]. Copyright 2021, Frontiers Media S.A. (B) MOF based CORNM through activating the metal notes.…”
Section: Cornms Based On Hybrid Nanomaterialsmentioning
“…Keli Zhong et al devised a nanodrug delivery system (DDS) ( Fig. 7 A) for tumor chemotherapy and CO gas therapy [ 104 ]. They encapsulated a manganese carbonyl complex (MnCO) and the anticancer drug camptothecin (CPT) within a zeolite-type MOF (ZIF-8), resulting in the formation of a stable DDS named ZCM.…”
Section: Cornms Based On Hybrid Nanomaterialsmentioning
confidence: 99%
“… Fig. 7 (A) A novel H 2 O 2 -triggered CO release MOF containing CORM and CPT for chemotherapy and gas therapy [ 104 ]. Copyright 2021, Frontiers Media S.A. (B) MOF based CORNM through activating the metal notes.…”
Section: Cornms Based On Hybrid Nanomaterialsmentioning
“…Delivery of chemotherapeutic drugs by ZIF–8 for specific release in tumor tissues is one of the most widely used therapeutic approaches in cancer research ( Table 2 ) [ 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 ]. Interestingly, as many other nanomaterials have been demonstrated to elicit pro–death autophagy [ 83 , 84 ], Xu et al found that ZIF–8 induced PI3K–regulated death–promoting autophagy [ 9 ].…”
Cancer severely threatens human health and has remained the leading cause of disease–related death for decades. With the rapid advancement of nanomedicine, nanoscale metal–organic frameworks are believed to be potentially applied in the treatment and biomedical imaging for various tumors. Zeolite imidazole framework (ZIF)–8 attracts increasing attention due to its high porosity, large specific surface area, and pH–responsiveness. The designs and modifications of ZIF–8 nanoparticles, as well as the strategy of drug loading, demand a multifaceted and comprehensive understanding of nanomaterial features and tumor characteristics. We searched for studies on ZIF–8–based nanoplatforms in tumor theranostics on Web of Science from 2015 to 2022, mainly focused on the research published in the past 3 years, summarized the progress of their applications in tumor imaging and treatment, and discussed the favorable aspects of ZIF–8 nanoparticles for tumor theranostics as well as the future opportunities and potential challenges. As a kind of metal–organic framework material full of potential, ZIF–8 can be expected to be combined with more therapeutic systems in the future and continue to contribute to all aspects of tumor therapy and diagnosis.
“…Nanotechnology has developed rapidly in recent years, providing a good means to overcome the bottleneck problem of nonspecific and non-selective damage to body tissues caused by traditional therapies (e.g., chemotherapy, radiotherapy and immunotherapy), and exhibiting unique advantages in improving the effects of drugs and radiation therapy while reducing adverse reactions (44,(56)(57)(58). On the one hand, multifunctional nanocarriers can selectively transport therapeutic drugs by utilizing the difference between the tumor tissue and normal tissue to enhance drug permeability and retention.…”
Section: Smart Np-based Systems For Bc Treatment Based On the Tmementioning
Breast cancer (BC) is the most common malignant tumor in women. There are different risk characteristics and treatment strategies for different subtypes of BC. The tumor microenvironment (TME) is of great significance for understanding the occurrence, development, and metastasis of tumors. The TME plays an important role in all stages of BC metastasis, immune monitoring, immune response avoidance, and drug resistance, and also plays an important role in the diagnosis, prevention, and prognosis of BC. Smart nanosystems have broad development prospect in the regulation of the BC drug delivery based on the response of the TME. In particular, TME-responsive nanoparticles cleverly utilize the abnormal features of BC tissues and cells to achieve targeted transport, stable release, and improved efficacy. We here present a review of the mechanisms underlying the response of the TME to BC to provide potential nanostrategies for future BC treatment.
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