Abstract:267
Humans with sickle cell disease (SCD) and hereditary spherocytosis (HS) have been shown to have increased plasma free hemoglobin, vascular dysfunction, and pulmonary hypertension. Increased plasma free hemoglobin (Hb) levels are associated with multiple physiologic findings, including hemoglobinuria, increased blood pressure, platelet activation, and increased mortality. Previously, we showed that SCD and HS mice have impaired systemic vasodilation and mild pulmonary hypertension. Furthermor… Show more
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