2023
DOI: 10.21037/atm-22-5741
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A novel human multiple myeloma cell line with a 1q21 gain genetic abnormality and CKS1B overexpression

Abstract: Background Multiple myeloma (MM) is an incurable hematologic malignancy mainly due to its cytogenetic abnormalities. Therefore, it is important to establish permanent malignant MM cell lines as tools to develop more effective therapies. Methods Pleural effusion cells of a 70-year-old patient was collected to establish the CZ2 cell line. Characterization of CZ2 was determined with nephelometry, flow cytometry, fluorescence in situ hybridization (FISH), and chromosomal mi… Show more

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