A novel human rotavirus serotype with dual G5-G11 specificity.

Timenetsky, María do Carmo Sampaio Tavares; Gouvêa, Vera; Santos, Norma; Carmona, Rita de Cássia Compagnoli; Hoshino, Yasutaka

doi:10.1099/0022-1317-78-6-1373

Cited by 48 publications

(36 citation statements)

References 27 publications

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“…Consubstanciando essa notória singularidade antigênica e genotípica, assinalem-se recentes observações de Santos et al (1998), no Rio de Janeiro, associando a ocorrência dos tipos G5, G8 e G10 a 40% dos quadros diarréicos agudos envolvendo crianças com idades inferiores a cinco anos. Reservou particular interesse nesse contexto a caracterização, em bases moleculares, de amostra viral oriunda de criança diarréica cuja dualidade antigênica se expressava em termos dos tipos G5 e G11 (Timenetsky et al, 1997). Este último, cumpre assinalar, reconhecido até então como um agente patogênico exclusivo de suínos.…”

Section: Sorotipos Genótipos E Eletroferotipos De Rotavírus No Brasiunclassified

Epidemiologia das infecções por rotavírus no Brasil e os desafios para o seu controle

Linhares

2000

Cad. Saúde Pública

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Section: Sorotipos Genótipos E Eletroferotipos De Rotavírus No Brasiunclassified

Epidemiologia das infecções por rotavírus no Brasil e os desafios para o seu controle

Linhares

2000

Cad. Saúde Pública

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“…These results could improve the understanding of RV transmission in tropics, paying close attention to human and climatological variables, and its relationship to other viral gastroenteritis pathogens. A major finding in the present study was the detection of the G2 P[4]+P [6] genotype, reflecting the importance of continued monitoring of RV strains circulating throughout the world.…”

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confidence: 80%

“…A P-mixed unusual infection G2P [4]+P [6] was detected in 1 sample from a 10-year-old unvaccinated male. The dual infection was confirmed by RT-PCR using specific set of primers; however, although several attempts were made to obtain the VP4 sequences from this sample, they were unsuccessful.…”

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confidence: 95%

“…RV-positive stool samples were typed after reverse transcription (RT) followed by semi-nested polymerase chain reaction (PCR) 6 and sequencing on an ABI 3100 thermocycler (Applied Biosystems, Foster City, CA, USA). Sequence data was aligned and edited with the BioEdit Sequence Alignment Editor (version 7.0.5.2) software (Ibis Therapeutics, Carlsbad, CA).…”

mentioning

confidence: 99%

“…In Nigeria, a G2 RV strain displaying dual P [4] and P [6] The inclusion of alternative P types in serotype G2 strain gene constellations may provide a means of escaping protective immunity and generating increased RV diversity 12 . Uncommon associations could also be related to reassortment between cocirculating RV strains 15 .…”

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confidence: 99%

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Rotavirus G2P[4] and G2P[4]+[6] infections during norovirus gastroenteritis outbreak: summer season 2010, Brazil

Luchs

Morillo

Ribeiro

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Introduction: This study aimed to monitor the seasonality of rotavirus infection, and gain insight into the variability of Brazilian strains. Methods: A total of 28 stool samples were analyzed from 698 revised cases of gastroenteritis during a norovirus outbreak in the summer of 2010 in Guarujá, Brazil. Diagnosis was performed using enzyme-linked immunosorbent assay (ELISA), reverse transcription polymerase chain reaction (RT-PCR), and sequencing. Results: Rotavirus infection was detected in 17.9% (5/28) of samples; 4 samples were G2P[4] genotype, and one G2P[4]+P[6] genotype. G2 and P[4] sequences showed a genetic relationship to strains from India and Russia, respectively. Conclusions: The seasonal pattern of rotavirus may be a consequence of human activity apart from climate factors.

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Serological and genomic characterization of human rotaviruses detected in China

Taniguchi

Urasawa

et al. 1998

J. Med. Virol.

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A total of 1,385 stool specimens were collected from children with diarrhea at two hospitals in Wuhan, Hubei Province, China, in 1994 and 1995, and screened for rotavirus by polyacrylamide gel electrophoresis of viral RNA. Group A rotavirus was detected with high frequency; 56.5% (87/154) and 40.8% (502/1,231) of the specimens collected in 1994 and 1995, respectively, were positive for rotavirus. Assignment of G serotype and P type (VP4 genotype) of group A rotavirus by ELISA with monoclonal antibodies and/or PCR, respectively, showed that strains of G2-P[4] and G1-P[8] specificity were predominant in 1994 and in 1995, respectively. In contrast, a single strain was found to have a P[9] type specificity, and no G4 strain was detected. Unusual combinations of RNA pattern-subgroup-G serotype-P type, such as long pattern-subgroup I-G1-P[8], short pattern-subgroup II-G3-P[4] and short pattern-subgroup I-G1-P[4], were detected in four specimens. Nucleotide sequences of the VP8* and/or NSP5 genes from two Chinese P[8] strains 470 and 582 and one Chinese P[9] strain 512 as well as five Japanese P[9] strains (K8, AU1, M318, 0264, and 0265) were determined and compared with the published sequences of the corresponding gene. In the phylogenetic tree of VP8* sequences of P[9] strains, which formed two clusters each having strain K8 or AU-1 as the representative strain, the Chinese P[9] strain was found in the cluster represented by AU-1, although it was most distantly related to other strains. While NSP5 sequences of human strains with P[9] specificity were related to simian and bovine strains, that of Chinese P[8] strains was most closely related to those of porcine strains. A single group C rotavirus (No. 208) was detected. Nucleotide sequences of its VP4, VP6, VP7, and NSP4 genes were very similar to those of group C human rotaviruses detected worldwide.

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A novel human rotavirus serotype with dual G5-G11 specificity.

Cited by 48 publications

References 27 publications

Epidemiologia das infecções por rotavírus no Brasil e os desafios para o seu controle

Epidemiologia das infecções por rotavírus no Brasil e os desafios para o seu controle

Rotavirus G2P[4] and G2P[4]+[6] infections during norovirus gastroenteritis outbreak: summer season 2010, Brazil

Serological and genomic characterization of human rotaviruses detected in China

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