“…Interestingly, several independent reports described mutations or downregulation of KLF6 gene in human malignancies such as in prostate cancer, astrocytic gliomas, colorectal cancer and non-small-cell lung cancer, thus KLF6 has been proposed as a potential candidate tumor suppressor gene (Narla et al, 2001;Chen et al, 2003;Jeng and Hsu, 2003;Reeves et al, 2004;Ito et al, 2004). Additionally, KLF6 regulates the transcription of several genes such as those encoding the pregnancyspecific glycoprotein 5 (PSG) (Koritschoner et al, 1997), transforming growth factor (TGF)-b1, types I and II TGF-b receptors (Kim et al, 1998), leukotriene C 4 synthase (LTC 4 ) (Zhao et al, 2000), urokinase plasminogen activator (uPA) (Kim et al, 1998) and inducible Nitric Oxide Synthase (Warke et al, 2003), most of which are implicated in proliferation and development of the tissues where they are expressed.…”