2024
DOI: 10.3389/fimmu.2024.1395018
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A novel humanized mouse model for HIV and tuberculosis co-infection studies

José Alejandro Bohórquez,
Sitaramaraju Adduri,
Danish Ansari
et al.

Abstract: BackgroundTuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), continues to be a major public health problem worldwide. The human immunodeficiency virus (HIV) is another equally important life-threatening pathogen. HIV infection decreases CD4+ T cell levels markedly increasing Mtb co-infections. An appropriate animal model for HIV/Mtb co-infection that can recapitulate the diversity of the immune response in humans during co-infection would facilitate basic and translational research in HIV/Mtb infec… Show more

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