A Novel In Vitro Tool to Study Cyst Nematode Chemotaxis

Laloum, Yohana; Ngala, Bruno M.; Ianszen, Mé Lina; Boulogne, Isabelle; Plasson, Carole; Fournet, Sylvain; Gotté, Maxime; Nguema-Ona, Éric; Roux, Anne-Claire Le; Gobert, Virginie; Driouich, Azeddine; Vicré, Maïté

doi:10.3389/fpls.2020.01024

Cited by 3 publications

(1 citation statement)

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“…Chemotaxis also occurs in the cyst nematodes [150]. FMRF-amide-like peptides (FLPs) are responsible for locomotion [151], so they could be responsible for initiation of movement after hatching in G. pallida, marking the activation of the dauer exit pathway in order to exploit a suitable food source, and ultimately, redirect development towards reproduction.…”

Section: Dauer In Clade 12 Parasitic Nematodesmentioning

confidence: 99%

On the role of dauer in the adaptation of nematodes to a parasitic lifestyle

et al. 2021

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Nematodes are presumably the most abundant Metazoa on Earth, and can even be found in some of the most hostile environments of our planet. Various types of hypobiosis evolved to adapt their life cycles to such harsh environmental conditions. The five most distal major clades of the phylum Nematoda (Clades 8–12), formerly referred to as the Secernentea, contain many economically relevant parasitic nematodes. In this group, a special type of hypobiosis, dauer, has evolved. The dauer signalling pathway, which culminates in the biosynthesis of dafachronic acid (DA), is intensively studied in the free-living nematode Caenorhabditis elegans, and it has been hypothesized that the dauer stage may have been a prerequisite for the evolution of a wide range of parasitic lifestyles among other nematode species. Biosynthesis of DA is not specific for hypobiosis, but if it results in exit of the hypobiotic state, it is one of the main criteria to define certain behaviour as dauer. Within Clades 9 and 10, the involvement of DA has been validated experimentally, and dauer is therefore generally accepted to occur in those clades. However, for other clades, such as Clade 12, this has hardly been explored. In this review, we provide clarity on the nomenclature associated with hypobiosis and dauer across different nematological subfields. We discuss evidence for dauer-like stages in Clades 8 to 12 and support this with a meta-analysis of available genomic data. Furthermore, we discuss indications for a simplified dauer signalling pathway in parasitic nematodes. Finally, we zoom in on the host cues that induce exit from the hypobiotic stage and introduce two hypotheses on how these signals might feed into the dauer signalling pathway for plant-parasitic nematodes. With this work, we contribute to the deeper understanding of the molecular mechanisms underlying hypobiosis in parasitic nematodes. Based on this, novel strategies for the control of parasitic nematodes can be developed.

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Section: Dauer In Clade 12 Parasitic Nematodesmentioning

confidence: 99%