For industrial buildings and logistics centres truck lifts are usually used. Therefore, there are special requirements for flatness tolerance of ground floor. The ground floor settlements differences in selected distances are limited. The article reviews the behaviour of soils and the importance of the actual behaviour assessment of soils during the design of floor slab on elastic subgrade. Particular attention is given to the behaviour of floor slab areas above pile foundations that support the building’s columns. Calculation results show the impact of subgrade stiffness on the behaviour of the floor slab, especially in areas above pile foundations, where the stiffness of subgrade is much higher. The article presents a solution for achieving the required level of settlements’ differences in areas where pile foundations for the building’s columns under the ground slab are used. The paper proposes an efficient engineering method to reduce ground slab settlements differences. The results of performed calculations confirm the efficiency of presented method.