A Novel Liposomal Formulation of Dithranol for Psoriasis: Preliminary Results

Agarwal, Ravindra; Saraswat, Abir; Kaur, Inderjeet; Katare, Om Prakash; Kumar, Bhushan

doi:10.1111/j.1346-8138.2002.tb00321.x

Cited by 39 publications

(28 citation statements)

References 9 publications

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“…In five patients they observed disappearance of the lesions without lesional or perilesional irritation, and without staining of the skin. These preliminary results indicate that liposomal dithranol has potential advantages over presently available preparations of dithranol [46,47]. Other drugs for which topical application is limited by irritation and related effects are benzoyl peroxide and tretinoin, therapeutic agents that have a place in the treatment of acne [48,49].…”

Section: Protection Against Side Effectsmentioning

confidence: 99%

“…Diclofenac associated with transfersomes shows prolonged activity and 10-fold higher concentrations of diclofenac in the subcutaneous tissue in comparison with the free drug in a commercial hydrogel [24]. Lactoferrin Arthritis [38] Oligonucleotides Lung inflammation [41][42][43][44] Protection against side effects Toxicity to healthy nontarget tissue Dithranol Skin disorders [46,47] Expert Opin. Drug Deliv.…”

Section: Liposomes As Penetration Enhancersmentioning

confidence: 99%

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Liposomes in the treatment of inflammatory disorders

Metselaar

Storm

2005

Expert Opinion on Drug Delivery

113

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This review focuses on the therapeutic utility of liposomes in the treatment of inflammatory disorders, and aims to offer the reader an overview of the in vivo results obtained with liposomally encapsulated anti-inflammatory and immune suppressive drugs. The past 30 years has clearly indicated the added value of liposomes in the search for solutions for the delivery problems encountered. However, only a few liposomal anti-inflammatory therapeutics have entered the clinic. Reasons for the hurdles existing in the translation of promising preclinical findings to clinical studies are discussed.

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Section: Protection Against Side Effectsmentioning

confidence: 99%

Section: Liposomes As Penetration Enhancersmentioning

confidence: 99%

Liposomes in the treatment of inflammatory disorders

Metselaar

Storm

2005

Expert Opinion on Drug Delivery

113

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“…Various approaches have been tried to overcome these problems like the use of penetration enhancers, select solvents and carrier-mediated transportation using niosomes, and micro-emulsified systems [6][7][8]. Earlier, our laboratory has reported the successful use of liposomal systems for topical delivery of dithranol and miconazole nitrate [10,11]. In the present study too, liposomes were chosen in an attempt to attain better access of NIM into the skin.…”

Section: Introductionmentioning

confidence: 99%

Design, Development and Optimization of Nimesulide-Loaded Liposomal Systems for Topical Application

Singh¹,

Mehta²,

Kumar³

et al. 2005

CDD

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Nimesulide, a non-steroidal anti-inflammatory drug, was incorporated into multilamellar liposomes to improve its performance on topical administration. The drug was loaded onto liposomes employing thin film hydration technique. Various process and formulation variables were investigated to obtain the liposomal products of desired quality. Liposomes were monitored for percent drug entrapment, after separating the unentrapped drug by mini column centrifugation, for vesicular properties (such as size distribution profile, morphological attributes and agglomeration tendency), drug diffused through synthetic semipermeable membrane, and drug leakage. Systematic optimization studies were carried out using 3(2) factorial design to select the optimized liposomal composition with reference to percent drug entrapment, drug diffusion and leakage. The optimized batch of liposomes was subjected to drug permeation and drug retention studies employing rat skin and human cadaver skin. In comparison to methanolic solution of pure nimesulide, liposomal formulations were found to retain higher amounts of nimesulide in the skin. Anti-inflammatory studies, using carragenan-induced rat paw edema model, indicated significantly better performance of liposomally entrapped nimesulide in comparison to the marketed gel formulation and the Carbopol gel containing nimesulide.

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“…In the case of the plaque type psoriasis, the entrapment of dithranol in liposomes has promoted its epidermal bioavailability and enabled the dose lowering, resulting in the reduction of consequent dose-dependent side-effects [43]. Conventional liposomes have also been examined for the targeting to the skin appendages [44,45], for improved treatment of hair follicle disorders such as alopecia.…”

Section: Conventional Liposomesmentioning

confidence: 99%

(Phospho)lipid-based Nanosystems for Skin Administration

Vanić¹,

Holæter²,

Škalko‐Basnet

2015

CPD

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Nanotechnology and nanomedicine provide a platform for advanced therapeutic strategies for dermal and transdermal drug delivery. The focus of this review is on the current state-of-art in lipid-based nanotechnology and nanomedicine for (trans)dermal drug therapy. Drug delivery nanosystems based on the (phospho)lipid constituents are characterized and compared, with the emphasis on their ability to assure the controlled drug release to the skin and skin appendages, drug targeting and safety. Different types of liposomes, biphasic vesicles, particulate lipid-based nanosystems and micro-and nano-emulsions are discussed in more details. Extensive research in preclinical studies has shown that numerous parameters including the composition, size, surface properties and their combinations affect the deposition and/or penetration of carrier-associated drug into/through the skin, and consequently determine the therapeutic effect. The superiority of the most promising nanopharmaceuticals has been confirmed in clinical studies. We have selected several common skin disorders and provided overview over promises of nanodermatology in antimicrobial skin therapy, anti-acne treatment, skin oncology, gene delivery and vaccines. We addressed the potential toxicity and irritation issues and provided an overview of registered lipid-based products

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A Novel Liposomal Formulation of Dithranol for Psoriasis: Preliminary Results

Cited by 39 publications

References 9 publications

Liposomes in the treatment of inflammatory disorders

Liposomes in the treatment of inflammatory disorders

Design, Development and Optimization of Nimesulide-Loaded Liposomal Systems for Topical Application

(Phospho)lipid-based Nanosystems for Skin Administration

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