A novel long noncoding RNA AK001796 acts as an oncogene and is involved in cell growth inhibition by resveratrol in lung cancer

Yang, Qiaoyuan; Xu, Enwu; Dai, Jiabin; Liu, Binbin; Han, Zhiyuan; Wu, Jianjun; Zhang, Shaozhu; Peng, Baoying; Zhang, Yajie; Jiang, Yiguo

doi:10.1016/j.taap.2015.04.003

Cited by 94 publications

(78 citation statements)

References 48 publications

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“…We at G1 phase. 17 We found that LINC00978 knockdown also resulted in G1 phase arrest in gastric cancer cells, leading to the inhibition of proliferation. LINC00978 is suggested to regulate multiple cell cycleassociated genes in lung cancer cells.…”

Section: Discussionmentioning

confidence: 78%

“…LINC00978 is suggested to regulate multiple cell cycleassociated genes in lung cancer cells. 17 We showed that LINC00978 knockdown upregulated the expression of p21, an important cell cycle regulator, indicating that LINC0097 is critically involved in the regulation of cell cycle progression. We also showed that LINC00978 knockdown induced apoptosis in gastric cancer cells, suggesting that LINC00978 may also promote gastric cancer cell proliferation by protecting them from apoptosis.…”

Section: Discussionmentioning

confidence: 81%

“…17 Further study revealed that LINC00978 can be used as a potential biomarker to predict prognosis in breast cancer patients. 18 Recently, LINC00978 was reported as one of the 4 serum lncRNAs that might serve as a panel for gastric cancer diagnosis.…”

Section: Discussionmentioning

confidence: 99%

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Long noncoding RNA LINC00978 promotes cancer growth and acts as a diagnostic biomarker in gastric cancer

Huang

Zang

et al. 2017

Cell Proliferation

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Objectives: Long noncoding RNAs (lncRNAs) play important roles in cancer development and progression. The deregulated expression of LINC00978 has been reported in human cancers. However, the expression pattern and biological roles of LINC00978 in gastric cancer (GC) remain unclear. In this study, we investigated the potential roles and clinical value of LINC00978 in gastric cancer. Materials and methods:QRT-PCR was performed to investigate the expression of LINC00978 in gastric cancer cell lines, tissues and serum samples. Cell counting, colony formation, transwell migration and matrigel invasion assays were performed to determine the effects of shRNA-mediated knockdown of LINC00978 on gastric cancer cell functions. In vivo tumour growth assay was also conducted. Flow cytometry, immunohistochemistry, western blot and qRT-PCR were used for potential mechanism study.Results: LINC00978 expression level was elevated in GC tumour tissues, serum samples and cell lines. The expression level of LINC00978 was significantly correlated with tumour size (P = 0.02), lymphatic metastasis (P = 0.009) and TNM stage (P = 0.009). LINC00978 knockdown inhibited the proliferation of GC cells by suppressing cell cycle progression and inducing apoptosis. LINC00978 knockdown also inhibited the migration and invasion of GC cells. In addition, LINC00978 knockdown inhibited the activation of TGF-β/SMAD signalling pathway and the process of epithelial-mesenchymal transition (EMT) in GC cells. Moreover, the in vivo tumorigenicity of LINC00978 knockdown GC cells in mice was significantly decreased.Conclusions: LINC00978 promotes gastric cancer progression and may serve as a potential biomarker for GC.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 81%

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Long noncoding RNA LINC00978 promotes cancer growth and acts as a diagnostic biomarker in gastric cancer

Huang

Zang

et al. 2017

Cell Proliferation

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“…Higher levels of ANRIL are regarded as a risk factor in several types of human cancers, including hepatocellular carcinoma (15), lung cancer (16), ovarian cancer (17), gastric cancer (18), bladder cancer (19), and colorectal cancer (20). ANRIL also regulates a large number of genes related to gene expression, cell proliferation, cell adhesion, and apoptosis (21), suggesting that ANRIL is involved in various cellular processes.…”

Section: Anril/cdkn2b-as1mentioning

confidence: 99%

Short-lived non-coding transcripts (SLiTs): Clues to regulatory long non-coding RNA

Tani

2017

DD&T

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“…NPs can enter cells via clathrin-or caveolin-mediated endocytosis, phagocytosis, macropinocytosis, or translocation. 20,21 In caveolin-mediated endocytosis, cell membrane invagination occurs in a flasklike shape. Here, the membrane proteins and caveolins bind to the membrane cholesterol and develop the vesicle.…”

mentioning

confidence: 99%

Future trends and emerging issues for nanodelivery systems in oral and oropharyngeal cancer

Irimie

Sonea²,

Jurj

et al. 2017

IJN

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Oral cancer is a prevalent cancer type on a global scale, whose traditional treatment strategies have several drawbacks that could in the near future be overcome through the development of novel therapeutic and prognostic strategies. Nanotechnology provides an alternative to traditional therapy that leads to enhanced efficiency and less toxicity. Various nanosystems have been developed for the treatment of oral cancer, including polymeric, metallic, and lipid-based formulations that incorporate chemotherapeutics, natural compounds, siRNA, or other molecules. This review summarizes the main benefits of using these nanosystems, in parallel with a particular focus on the issues encountered in medical practice. These novel strategies have provided encouraging results in both in vitro and in vivo studies, but few have entered clinical trials. The use of nanosystems in oral cancer has the potential of becoming a valid therapeutic option for patients suffering from this malignancy, considering that clinical trials have already been completed and others are currently being developed.

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A novel long noncoding RNA AK001796 acts as an oncogene and is involved in cell growth inhibition by resveratrol in lung cancer

Cited by 94 publications

References 48 publications

Long noncoding RNA LINC00978 promotes cancer growth and acts as a diagnostic biomarker in gastric cancer

Long noncoding RNA LINC00978 promotes cancer growth and acts as a diagnostic biomarker in gastric cancer

Short-lived non-coding transcripts (SLiTs): Clues to regulatory long non-coding RNA

Future trends and emerging issues for nanodelivery systems in oral and oropharyngeal cancer

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