A novel long noncoding RNA HOXC-AS3 mediates tumorigenesis of gastric cancer by binding to YBX1

Zhang, Erbao; He, Xu; Zhang, Chongguo; Sawada, Jun; Lu, Xiyi; Si, Xinxin; Chen, Jinfei; Yin, Dandan; Han, Liang; De, Wei

doi:10.1186/s13059-018-1523-0

Cited by 238 publications

(208 citation statements)

References 44 publications

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“…Increasing evidences revealed that non‐coding RNAs, particularly lncRNAs and miRNAs, have considerable potential values in improving the diagnostic and therapeutic of GC . Researchers have found a large number of lncRNAs in GC development, such as lncRNA HOXC‐AS3, LINC01234 and lncRNA‐KRTAP5‐AS1 . Aberrantly expressed lncRNAs are involved in various malignant cytological behaviours of GC cells.…”

Section: Discussionmentioning

confidence: 99%

Long non‐coding RNA MYOSLID functions as a competing endogenous RNA to regulate MCL‐1 expression by sponging miR‐29c‐3p in gastric cancer

Han

Jiang

et al. 2019

Cell Proliferation

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Objective Long non‐coding RNA (lncRNA) has become an important regulator of many human malignancies. However, the biological role and clinical significance of most lncRNA in gastric cancer (GC) remain unclear. Methods We investigate the biological function, mechanism of action and clinical expression of lncRNA MYOSLID in GC. First, we analysed the differential expression of lncRNA MYOSLID in GC tissues and non‐cancerous tissues by analysing the sequencing data obtained from The Cancer Genome Atlas. Subsequently, we verified that lncRNA MYOSLID regulates the proliferation and apoptosis of GC cells by acting as a ceRNA against miR‐29c‐3p. The nude mouse xenograft was used to further confirm the functional significance of lncRNA MYOSLID in vivo. Results We found for the first time that the expression of lncRNA MYOSLID was significantly up‐regulated in GC tissues, and the up‐regulation of lncRNA MYOSLID in GC was correlated with tumour size, AJCC stage, depth of invasion and survival time. In addition, apoptosis and growth arrest can be induced in vitro after knockdown of lncRNA MYOSLID, which inhibits tumorigenesis in mouse xenografts in vivo. Further in‐depth studies revealed that lncRNA MYOSLID acts as a ceRNA of miR‐29c‐3p, resulting in de‐repression of its downstream target gene MCL‐1. Conclusion The lncRNA MYOSLID‐miR‐29c‐3p‐MCL‐1 axis plays a key role in the development of GC. Our findings may provide potential new targets for the diagnosis and treatment of human GC.

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Section: Discussionmentioning

confidence: 99%

Long non‐coding RNA MYOSLID functions as a competing endogenous RNA to regulate MCL‐1 expression by sponging miR‐29c‐3p in gastric cancer

Han

Jiang

et al. 2019

Cell Proliferation

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“…37,47 Studies have reported that YB1 can regulate proliferation and metastasis by binding to lncRNAs 37,47 or miRNAs, 48 and even demonstrate that YB1 effects EMT. 37,47 Studies have reported that YB1 can regulate proliferation and metastasis by binding to lncRNAs 37,47 or miRNAs, 48 and even demonstrate that YB1 effects EMT.…”

Section: Discussionmentioning

confidence: 99%

LINC00511 contributes to glioblastoma tumorigenesis and epithelial‐mesenchymal transition via LINC00511/miR‐524‐5p/YB1/ZEB1 positive feedback loop

Liu

et al. 2019

J Cellular Molecular Medi

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Tumour invasion is closely related to the prognosis and recurrence of glioblastoma multiforme and partially attributes to epithelial‐mesenchymal transition. Long intergenic non‐coding RNA 00511 (LINC00511) plays a pivotal role in tumour; however, the role of LINC00511 in GBM, especially in the epigenetic molecular regulation mechanism of EMT, is still unclear. Here, we found that LINC00511 was up‐regulated in GBM tissues and relatively high LINC00511 expression predicted poorer prognosis. Moreover, ectopic LINC00511 enhanced GBM cells proliferation, EMT, migration and invasion, whereas LINC00511 knockdown had the opposite effects. Mechanistically, we confirmed that ZEB1 acted as a transcription factor for LINC00511 in GBM cells. Subsequently, we found that LINC00511 served as a competing endogenous RNA that sponged miR‐524‐5p to indirectly regulate YB1, whereas, up‐regulated YB1 promoted ZEB1 expression, which inversely facilitated LINC00511 expression. Finally, orthotopic xenograft models were performed to further demonstrate the LINC00511 on GBM tumorigenesis. This study demonstrates that a LINC00511/miR‐524‐5p/YB1/ZEB1 positive feedback loop provides potential therapeutic targets for GBM progression.

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“…[26][27][28][29] A recent study reported that YBX1 participates in HOXC-AS3-mediated gene transcription, further regulating the tumorigenesis of gastric cancer. 30 However, the mechanism of HOXC-AS3 to regulate GBM cell progression is not clear, which requires further study and discussion.…”

Section: Discussionmentioning

confidence: 99%

HOXB13 promotes proliferation, migration, and invasion of glioblastoma through transcriptional upregulation of lncRNA HOXC‐AS3

Wang

Sun

et al. 2019

J of Cellular Biochemistry

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HOXB13 exerts a close relation in several human cancers. This study explored the role of HOXB13 in glioblastoma (GBM), a brain tissue with the highest aggressive rate and mortality in adults. Through microarray and immunohistochemistry analyses, HOXB13 was highly expressed in GBM tissues. Furthermore, we showed that high‐level expression of HOXB13 in GBM was associated with worse survival, suggesting that HOXB13 could be a prognostic marker for patients with GBM. GBM cells U87 and U251 overexpressing HOXB13 showed enhanced proliferation, migration, and invasion relative to the control cells, while knockdown of HOXB13 led to decreased cell proliferation, migration, and invasion abilities. In addition, dual‐luciferase report assay, chromatin immunoprecipitation assay, and quantitative real‐time polymerase chain reaction data showed that HOXB13 directly bound to HOXC‐AS3 promoter. HOXC‐AS3 was involved in HOXB13‐induced proliferation, migration, and invasion of GBM cells. In summary, this study revealed the prognostic potential of HOXB13 in GBM. We believed that HOXB13/HOXC‐AS3 signaling axis can be served as therapeutic targets for this highly aggressive cancer.

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A novel long noncoding RNA HOXC-AS3 mediates tumorigenesis of gastric cancer by binding to YBX1

Cited by 238 publications

References 44 publications

Long non‐coding RNA MYOSLID functions as a competing endogenous RNA to regulate MCL‐1 expression by sponging miR‐29c‐3p in gastric cancer

Long non‐coding RNA MYOSLID functions as a competing endogenous RNA to regulate MCL‐1 expression by sponging miR‐29c‐3p in gastric cancer

LINC00511 contributes to glioblastoma tumorigenesis and epithelial‐mesenchymal transition via LINC00511/miR‐524‐5p/YB1/ZEB1 positive feedback loop

HOXB13 promotes proliferation, migration, and invasion of glioblastoma through transcriptional upregulation of lncRNA HOXC‐AS3

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