A novel method for calculating prevalence of multiple sclerosis in Australia

Palmer, Andrew J.; Hitchens, Peta L.; Simpson, Steve; O'Leary, BA; Colman, Sam; Taylor, Bruce

doi:10.1177/1352458513479841

Cited by 20 publications

(24 citation statements)

References 23 publications

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“…There was generally higher use of RRMS DMM in the more southerly Australian administrative areas than in the more northerly ones, consistent with the known higher prevalence of the disease with increasing distance from the equator in both hemispheres [16][17][18][19][20][21][22][23], the reasons for which remain unclear [24]. There was, however, an exception to this relationship in the relatively high use of RRMS DMM in the ACT, compared with their use in the surrounding state of NSW -a usage pattern driven by heavy prescribing of glatiramer acetate in the ACT.…”

Section: Discussionsupporting

confidence: 70%

“…There was, however, an exception to this relationship in the relatively high use of RRMS DMM in the ACT, compared with their use in the surrounding state of NSW -a usage pattern driven by heavy prescribing of glatiramer acetate in the ACT. There is no obvious explanation for the different patterns of preferred use of the various agents in the different jurisdictions, apart from consequences of individual neurologist preferences [23]. The differences are more noticeable in jurisdictions with fewer people and fewer neurologists where one neurologist's different pattern of practice may have more obvious consequences for the data.…”

Section: Discussionmentioning

confidence: 96%

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Multiple sclerosis disease modifying medicine utilisation in Australia

Hollingworth¹,

Walker²,

Page³

et al. 2014

Journal of Clinical Neuroscience

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 96%

Multiple sclerosis disease modifying medicine utilisation in Australia

Hollingworth¹,

Walker²,

Page³

et al. 2014

Journal of Clinical Neuroscience

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“…In nearly all of these regions, a statistically significant association could be shown with either the MS prevalence, or the MS mortality, or the regional “case-control ratio” as an indicator of MS prevalence, ([39–49]; Table 1). Only in Australia, including seven territories, did a more complex pattern emerge [50]: whereas the MS prevalence based on data from the MS society 2010 [51], as compared with diet in 1995 [52], indicated an even “protective” role of processed meat ( n = 7; r S = −0.739; p = 0.058), data from the Survey of Disability, Ageing and Carers (SDAC) of the Australian Bureau of Statistics [51] revealed exactly the reverse ( n = 7; r S = +0.775; p = 0.041; [50], Table 1). Since this data source included only the more disabled patients of MS, it might be speculated that processed food causes a more severe course of MS rather than the risk per se .…”

Section: Further Epidemiological Findings In Support Of the Hypothesismentioning

confidence: 99%

Notes on the Epidemiology of Multiple Sclerosis, with Special Reference to Dietary Habits

Lauer¹

2014

IJMS

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A hypothesis, based primarily on the occurrence of multiple sclerosis (MS) in the Faroe Islands and supported by numerous analytical epidemiological studies, is described. It proposes that MS is caused by the interaction of a virus disease with intestinal pathology, e.g., infectious mononucleosis, and application of smoked and nitrate/nitrite-cured meat products in the diet during circumscribed time intervals. The biological mechanisms might involve a break of tolerance by an alteration of self within the central nervous system, by nitrophenylated compounds conjugated to animal tissue, in particular to proteins occurring in the central nervous system. Further research is needed.

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“…With unknown aetiology, MS is the most common CNS disease in people under the age of 40 years and is more prevalent in women . In Australia, MS affects 95 per 100 000 people . The disease is characterized by relapses of neurological dysfunction that generally plateau, followed by either complete or incomplete improvement .…”

Section: Introductionmentioning

confidence: 99%

Oral health and behaviours of people living with Multiple Sclerosis in Australia

Sexton

Lalloo

Stormon

et al. 2019

Comm Dent Oral Epid

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Objectives The literature describing the oral health of people with Multiple Sclerosis (MS) is scant and the findings equivocal. The aim of this study was to describe the oral health and oral self‐care behaviours of people living with MS and compare it to the Australian population. Methods Participants enrolled with the Australian MS Longitudinal Study (AMSLS) were invited to participate in the survey using an online or paper‐based questionnaire. Data were collected on level of disability, oral health, oral self‐care and factors influencing attendance for oral health care. Results Completed questionnaires were received for 1523 respondents. Over one‐fifth (n = 320; 22%) rated their oral health as fair or poor, and more than half (n = 840; 57%) reported toothache in the last 12 months. These proportions were higher than those for the general Australian adult population (oral health prevalence ratio (PR) = 1.25 [1.12, 1.40]; toothache PR = 3.63 [3.39, 3.88]), and this is despite comparable or better self‐maintenance habits and dental attendance reported by respondents. People with MS reported high rates of mouth dryness (68.4%), teeth sensitivity (64.7%), change of taste (40.5%) and orofacial pain (39.0%); fewer than 10% experienced none of these. There was a lower prevalence of self‐reported need for treatment (extraction or filling) than in the Australian adult population (15.8% vs 32.9%). Conclusions People with MS have a greater oral health burden, demonstrated by their poorer self‐reported oral health than the Australian adult population. Furthermore, they experience high rates of toothache, mouth dryness, teeth sensitivity, change of taste and orofacial pain. These findings are contrary to their self‐reported good oral self‐care and dental attendance habits and suggest some of the oral health impacts are due to MS rather than dental behaviours.

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A novel method for calculating prevalence of multiple sclerosis in Australia

Abstract: Calculation of prevalence of MS using nation-wide prescription data is a novel method that generates results similar to other potentially more resource-intensive methods.

Cited by 20 publications

References 23 publications

Multiple sclerosis disease modifying medicine utilisation in Australia

Multiple sclerosis disease modifying medicine utilisation in Australia

Notes on the Epidemiology of Multiple Sclerosis, with Special Reference to Dietary Habits

Oral health and behaviours of people living with Multiple Sclerosis in Australia

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