A Novel Method for miRNA-Disease Association Prediction based on Space Projection and Label Propagation (SPLPMDA)

Abstract

miRNAs, a subclass of non-coding small RNAs, are about 18-22 nucleotides long. It has been revealed that miRNAs are responsible many diseases such as cancer. Therefore, great efforts have been made recently by researchers to explore possible relationships between miRNAs and diseases. Experimental studies to identify new disease-associated miRNAs are very expensive and at the same time a long process. Therefore, to determine the relationships between miRNA and disease many computational methods have been developed. In this paper, a new method for the identification of miRNA-disease associations based on space projection and label propagation (SPLPMDA) is proposed. The forecast the precision of SPLPMDA was demonstrated using 5-fold cross-validation and LOOCV techniques. Values of 0.9333 in 5-fold cross validation and 0.9441 in LOOCV were obtained. Moreover, case studies on breast neoplasms and lymphoma were performed to further confirm the predictive reliability of SPLPMDA.