A novel method of extraction of bamboo seed oil (Bambusa bambos Druce) and its promising effect on metabolic symptoms of experimentally induced polycystic ovarian disease

Soumya, V; Muzib, Y. Indira; Venkatesh, P

doi:10.4103/0253-7613.178833

Cited by 30 publications

(15 citation statements)

References 13 publications

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“…Vaginal smears were taken using cotton buds dipped in saline and allowed to dry after rolling on a clean slide to confirm PCOS induction. According to, cells were fixed in methanol, allowed to dry, and stained with 0.76 g giemsa [ 44 ].…”

Section: Methodsmentioning

confidence: 99%

Turmeric extract alleviates endocrine-metabolic disturbances in letrozole-induced PCOS by increasing adiponectin circulation: A comparison with Metformin

Shah

Shrivastava

2022

Metabolism Open

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One of the most common causes of female infertility is polycystic ovarian syndrome, which affects 6–21% of the population. Regrettably, the currently available treatments are mostly symptomatic and ineffective. As a result, safer options are needed now more than ever. In a letrozole PCOS albino mouse model, the current study compares the therapeutic advantages of Turmeric extract (Curcuma longa) to metformin. Adiponectin is a circulating protein generated by adipocytes that has been linked to metabolic diseases (MDs) in an inverse relationship. The effects of Turmeric Extract (Curcuma Longa) in contrast to Metformin, as well as the involvement of adiponectin in endocrine-metabolic abnormalities in experimentally induced PCOS mice model, were studied in this study. Letrozole (6 mg/kg) was administered orally (p.o) for 21 days to induce PCOS, followed by a dose of Turmeric Extract (Curcuma longa) (175 mg/kg and p.o) and Metformin (150 mg/kg) for 30 days, both with normal saline water (0.9%) as the carrier. The findings revealed that LET-treated mice displayed PCOS-like characteristics, such as higher LH levels, increased body weight growth, and ovarian morphology with numerous cysts, increase in fasting blood glucose, lipid profile, plasma lipid peroxidation (MDA) and IL-6, as well as a decrease in serum Progesterone, Estrogen, FSH, SOD and GSH levels in the ovary. These changes were linked to lower levels of circulating adiponectin and were reversed when treated Turmeric extract. By altering circulating androgen-adiponectin balance, the data implies that Turmeric extract alleviates endocrine-metabolic abnormalities and inflammation-related comorbidities associated with LET-induced PCOS.

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Section: Methodsmentioning

confidence: 99%

Turmeric extract alleviates endocrine-metabolic disturbances in letrozole-induced PCOS by increasing adiponectin circulation: A comparison with Metformin

Shah

Shrivastava

2022

Metabolism Open

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“…Various solvents, including ethanol, methanol, butanol, hexane, methylene chloride, ethyl acetate and water may be used for solvent extraction ( 7 , 24 , 26 , 27 ). A novel method of microwave-assisted extraction was also developed for the extraction of Bambusa bambos ( 28 ). Different solubility and boiling points are noted between different types of solvents ( 24 , 29 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Bambusaï¿½tulda on the proliferation of human stem cells

Lee

Uddin²,

Lee

et al. 2017

Exp Ther Med

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To date, the effects of Bambusa tulda on stem cells have not been thoroughly assessed. The present study aimed to evaluate the effects of Bambusa tulda extract on the morphology and proliferative potential of human mesenchymal stem cells derived from the gingiva. The stem cells were cultured in a growth medium in the presence of Bambusa tulda methanolic extract (BBT) at concentrations ranging from 0.001 to 1%. Evaluation of cell morphology and cellular proliferation as well as immunofluorescent assays for collagen I were performed on days 1, 3, 5 and 7. Stem cells in the control group displayed a fibroblast-like morphology, and BBT treatment did not produce any noticeable morphological changes. However, application of 1% BBT produced a significant increase in cell proliferation. BBT, particularly at the concentration of 1%, also caused a noticeable increase of collagen I expression at day 1 and day 3. Based on these findings, it was concluded that BBT exerted beneficial effects on the proliferation of mesenchymal stem cells and enhanced collagen I expression at early time points.

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“…[22][23][24] The animals received following treatment A total of 30 Adult female wistar albino rats are divided into 5 groups of 6 animals each. …”

Section: Methodsmentioning

confidence: 99%

“…Vaginal Smears were collected daily and evaluated microscopically using Crystal violet stain to confirm the induction of PCOS. [22][23][24] …”

Section: Pcos Inductionmentioning

confidence: 99%

The Pharmacological Activity of Leaves of Erythrina Variegata Linn., on Metabolic Symptoms of Experimentally Induced Polycystic Ovarian Disease

Shalini¹

2017

WJPPS

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To evaluate the beneficial effect of Ethanolic extract of Erythrina variegata Linn., in decreasing the major metabolic symptoms associated with Letrozole induced Polycystic Ovarian Disease (PCOD or PCOS) using female rat model. Erythrina variegata Linn., is commonly known as Indian coral tree belongs to the family of Fabaceae. Female wistar albino rats were grouped into five groups with six animals each. All rats were daily administered with letrozole (1mg/kg b.tw.) for 21 days except control, and during this period, changes in estrus cycle were observed. After letrozole treatment, group 2 was considered negative control, group 3 was considered standard, group 4 and 5 were treated orally with Ethanolic extract of Erythrina variegata Linn., 200 mg/kg b.wt. and 400 mg/kg b.wt., respectively, for 4 weeks (7 consecutive estrus cycles). Various parameters such as estrus cycle, blood sugar level, lipid profile and weights of reproductive system were determined. The characteristic of ovary and uterus were evaluated by histopathological studies.

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A novel method of extraction of bamboo seed oil (Bambusa bambos Druce) and its promising effect on metabolic symptoms of experimentally induced polycystic ovarian disease

Cited by 30 publications

References 13 publications

Turmeric extract alleviates endocrine-metabolic disturbances in letrozole-induced PCOS by increasing adiponectin circulation: A comparison with Metformin

Turmeric extract alleviates endocrine-metabolic disturbances in letrozole-induced PCOS by increasing adiponectin circulation: A comparison with Metformin

Effects of Bambusaï¿½tulda on the proliferation of human stem cells

The Pharmacological Activity of Leaves of Erythrina Variegata Linn., on Metabolic Symptoms of Experimentally Induced Polycystic Ovarian Disease

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