A novel method to produce solid lipid nanoparticles using n-butanol as an additional co-surfactant according to the o/w microemulsion quenching technique

Mojahedian, Mohammad Mahdi; Daneshamouz, Saeid; Mohammadi-Samani, Soliman; Zargaran, Arman

doi:10.1016/j.chemphyslip.2013.05.001

Cited by 28 publications

(8 citation statements)

References 12 publications

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“…Lipid nanoparticles could be prepared by different methods such as hot and cold high pressure homogenization( 13 14 ), solvent emulsification/evaporation( 15 ), microemulsion formation technique( 16 ), and ultrasonic solvent emulsification( 3 ). Large-scale productions of lipid nanoparticles are mainly obtained by high pressure homogenization technique.…”

Section: Methods Of Lipid Nano-particles Preparationmentioning

confidence: 99%

Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages

2018

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During the recent years, more attentions have been focused on lipid base drug delivery system to overcome some limitations of conventional formulations. Among these delivery systems solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are promising delivery systems due to the ease of manufacturing processes, scale up capability, biocompatibility, and also biodegradability of formulation constituents and many other advantages which could be related to specific route of administration or nature of the materials are to be loaded to these delivery systems. The aim of this article is to review the advantages and limitations of these delivery systems based on the route of administration and to emphasis the effectiveness of such formulations.

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Section: Methods Of Lipid Nano-particles Preparationmentioning

confidence: 99%

Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages

2018

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“…These emulsion droplets on cooling produced relatively small nanoparticles [33,38]. Additionally, this combined surfactant solution acted as a steric stabiliser by preventing their coalescence, leading to high drug entrapment [38,39]. Thus, the amount of combined surfactant was chosen as 0.5 g, due to the relatively small particle size and high entrapment efficiency.…”

Section: Irinotecan-loaded Thermosensitive Slnmentioning

confidence: 99%

Particle and Gel Characterization of Irinotecan-Loaded Double-Reverse Thermosensitive Hydrogel

2021

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The irinotecan-loaded double-reverse thermosensitive hydrogel (DRTH) is a dispersed system of irinotecan-loaded solid lipid nanoparticles (SLN) in a thermosensitive hydrogel. To optimise the particle and gel properties of DRTHs for rectal administration of irinotecan, SLNs and DRTHs were prepared with tricaprin, triethanolamine, Tween 80, and Span 20. Among the SLNs tested, an SLN composed of 1 g irinotecan, 0.5 g lipid mixture, and 0.5 g combined surfactant gave the highest entrapment efficiency and smallest particle size. A DRTH composed of (poloxamer 407/poloxamer 188/combined surfactant/SLN dispersion/H2O (10/15/17/4/54%)) showed easy administration, fast gelling, and strong gel-forming in the body.

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“…is was the reason why the molecules of Brij 721 and Myrj 52 were small and could cover the particle's surface with more stability. Concerning microemulsion preparation using the surfactant with small particles or cosurfactant, the microemulsion remained more stable than using the surfactant with large particles [15,[19][20][21][22]. Figure 7 shows the morphology of SLN from both types of surfactants (Brij 721; Myrj 52), which had spherically-shaped particles under SEM.…”

Section: Characteristics Of Stingless Bee Wax Solid Nanoparticlesmentioning

confidence: 99%

Development and Characterization of Stingless Bee Propolis Properties for the Development of Solid Lipid Nanoparticles for Loading Lipophilic Substances

Khongkaew

Chaemsawang

2021

International Journal of Biomaterials

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Stingless bees are insects which are popularly bred by agriculturists in the eastern region of Thailand for the pollination of their orchards. The products from stingless bee breeding include bee honey and bee propolis. The objective of this experiment is to study the possibility of developing stingless bee propolis wax into solid lipid nanoparticles (SLN) by the comparison of five surfactants (Brij 721, Cremophor WO 7, Myrj 52, Poloxamer 188, and Tween 80). Each surfactant is used at three concentrations: 10%, 20%, and 30%. A master formula is selected according to the following: physical features, particle size, zeta potential, and entrapment. The results showed that Brij 721 and Myri 52 at 20% can be used in preparing SLN and have good preservation properties for vitamin E (size: 451.2 nm and 416.8 nm, zeta potential: - 24.0 and - 32.7; % EE: 92.32% and 92.00%, resp.). Therefore, they are further developed by adding the following drugs at low solubility: curcumin, ibuprofen, and astaxanthin. It is found that a formula using the surfactants Brij 721 and Myrj 52 at 20% have similar drug entrapment. The entrapment study involves curcumin 82%, ibuprofen 40%, and astaxanthin 67%. Moreover, the cytotoxicity test of blank solid lipid nanoparticle found no toxicty in fibroblast cell line (CRL-2522). Therefore, from this study, it is determined that stingless bee propolis wax has the potential to be developed to provide more efficient SLN in the future.

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A novel method to produce solid lipid nanoparticles using n-butanol as an additional co-surfactant according to the o/w microemulsion quenching technique

Cited by 28 publications

References 12 publications

Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages

Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages

Particle and Gel Characterization of Irinotecan-Loaded Double-Reverse Thermosensitive Hydrogel

Development and Characterization of Stingless Bee Propolis Properties for the Development of Solid Lipid Nanoparticles for Loading Lipophilic Substances

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