A novel microfluidic driver via AC electrokinetics

Kuo, Cheng-Tzu; Liu, Cheng-Hsien

doi:10.1039/b719968f

Cited by 17 publications

(14 citation statements)

References 22 publications

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“…2(c)), 31,32 partial modification of the surface of the electrodes with dielectrics ( Fig. 2(d)), 33 and the use of ACETF. 34…”

Section: •1 Fluid Pumpingmentioning

confidence: 99%

Recent Applications of AC Electrokinetics in Biomolecular Analysis on Microfluidic Devices

Sasaki

2012

ANAL. SCI.

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AC electrokinetics is a generic term that refers to an induced motion of particles and fluids under nonuniform AC electric fields. The AC electric fields are formed by application of AC voltages to microelectrodes, which can be easily integrated into microfluidic devices by standard microfabrication techniques. Moreover, the magnitude of the motion is large enough to control the mass transfer on the devices. These advantages are attractive for biomolecular analysis on the microfluidic devices, in which the characteristics of small space and microfluidics have been mainly employed. In this review, I describe recent applications of AC electrokinetics in biomolecular analysis on microfluidic devices. The applications include fluid pumping and mixing by AC electrokinetic flow, and manipulation of biomolecules such as DNA and proteins by various AC electrokinetic techniques. Future prospects for highly functional biomolecular analysis on microfluidic devices with the aid of AC electrokinetics are also discussed.

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“…2(c)), 31,32 partial modification of the surface of the electrodes with dielectrics ( Fig. 2(d)), 33 and the use of ACETF. 34…”

Section: •1 Fluid Pumpingmentioning

confidence: 99%

Recent Applications of AC Electrokinetics in Biomolecular Analysis on Microfluidic Devices

Sasaki

2012

ANAL. SCI.

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“…Recently, AC electroosmotic flow (AC-EOF) has attracted an increasing research interest, and shown great potential for lab-on-a-chip applications, such as fluid pumping (Brown et al 2001;Debesset et al 2004;Kuo and Liu 2008), fluid mixing (Sasaki et al 2006;Kim et al 2007), transportation (Tresset and Takeuchi 2005;Hilber et al 2008), as well as concentration of bioparticles (Wong et al 2004;Bown and Meinhart 2006), with its low-voltage operation (\10 Vrms), and operated frequency below 1 MHz. Basically, AC-induced flow originates from the applied AC voltage to planar electrodes immersed in a liquid electrolyte.…”

Section: Introductionmentioning

confidence: 99%

Configurable AC electroosmotic generated in-plane microvortices and pumping flow in microchannels

Huang

Hsueh

Hung

2009

Microfluid Nanofluid

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This paper proposes the patterned AC electroosmotic flows (AC-EOF) by simply grouping discrete electrodes together to form various electrode configurations for generation of in-plane microvortices with clockwise/counter-clockwise rotation, and pumping flow in a microchannel. The rotational direction of in-plane microvortices and pumping flow direction can be controlled using the same electrode pattern by simple switching of the voltages on the electrodes. Microparticle image velocimetry (lPIV) was used to characterize the flow fields of the generated in-plane microvortices and pumping flow. The rotational strength of microvortices and flow rates of pumping flows were found to increase with the increase of the applied voltages, and an optimal value was achieved at an appropriately applied frequency. Moreover, the dependency of the applied voltages, frequencies, and the heights of the measured planes on the rotational strength of inplane microvortices between the interdigitated and discrete electrode configurations were examined. The discrepancy in electrode geometry results in a small performance reduction, whereas it can be compensated for the ability of switching the rotational direction of in-plane microvortices using the same device. The configurable in-plane microvortices and pumping flow in microchannels provide the potential for micromixing applications and for the integration into a lab-on-a-chip system.

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“…Over the last decade, considerable efforts have been devoted to the exploration of ACEO based on the concept of travelling-wave ACEO using asymmetric electrode arrays. [4][5][6][7][8][9][10] To be asymmetric, the EO must be non-linear. One of the mechanisms of EO non-linearity is due to ionic concentration polarization (CP).…”

Section: Introductionmentioning

confidence: 99%

Asymmetric electroosmotic pumping across porous media sandwiched with perforated ion-exchange membranes

et al. 2017

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To have non-zero net flow in AC electroosmotic pumps, the electroosmosis (EO) has to be non-linear and asymmetric. This can be achieved due to ionic concentration polarization. This is known to occur close to micro-/nano-interfaces provided that the sizes of the nanopores are not too large compared to the Debye screening length. However, operation of the corresponding EO pumps can be quite sensitive to the solution concentration and, thus, unstable in practical applications. Concentration polarization of ion-exchange membranes is much more robust. However, the hydraulic permeability of the membrane is very low, which makes EO flows through them extremely small. This communication shows theoretically how this problem can be resolved via making scarce microscopic perforations in an ion-exchange membrane and putting it in series with an EO-active nano-porous medium. The problem of coupled flow, concentration and electrostatic-potential distributions is solved numerically by using finite-element methods. This analysis reveals that even quite scarce perforations of micron-scale diameters are sufficient to observe practically-interesting EO flows in the system. If the average distance between the perforations is smaller than the thickness of the EO-active layer, there is an effective homogenization of the electrolyte concentration and hydrostatic pressure in the lateral direction at some distance from the interface. The simulations show this distance to be somewhat lower than the half-distance between the perforations. On the other hand, when the surface fraction of perforations is sufficiently small (below a fraction of a percent) this "homogeneous" concentration is considerably reduced (or increased, depending on the current direction), which makes the EO strongly non-linear and asymmetric. This analysis provides initial guidance for the design of high-productivity and inexpensive AC electroosmotic pumps.

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A novel microfluidic driver via AC electrokinetics

Cited by 17 publications

References 22 publications

Recent Applications of AC Electrokinetics in Biomolecular Analysis on Microfluidic Devices

Recent Applications of AC Electrokinetics in Biomolecular Analysis on Microfluidic Devices

Configurable AC electroosmotic generated in-plane microvortices and pumping flow in microchannels

Asymmetric electroosmotic pumping across porous media sandwiched with perforated ion-exchange membranes

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