A novel missense mutation (L280V) within POU1F1 gene strongly affects litter size and growth traits in goat

Zhang, Yanghai; Cui, Wenbo; Yang, Han; Wang, Min; Yan, Hailong; Zhu, Haijing; Liu, Jinwang; Liu, Qu; Lan, Xianyong; Pan, Chuanying

doi:10.1016/j.theriogenology.2019.06.021

Cited by 25 publications

(9 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In previous studies, SNPs in genes were shown to be associated with growth traits and litter size in goats [30][31][32][33]. Indels similarly present relationships with growth traits [34,35], as observed for a 12 bp indel in GDF9 that is related to first-born litter size in goats [4], and a 14 bp indel in CMTM2 that shows a relationship with litter size in goats [24].…”

Section: Discussionmentioning

confidence: 58%

Detection of rs665862918 (15-bp Indel) of the HIAT1 Gene and its Strong Genetic Effects on Growth Traits in Goats

Gao

Song

et al. 2020

Animals

Self Cite

View full text Add to dashboard Cite

The hippocampus abundant transcript 1 (HIAT1) gene, which was detected by the genome-wide identification of selective sweeps among elite goat breeds and water buffalo, is proposed to play an important role in meat characteristics. Four indels of the HIAT1 gene selected from the NCBI and Ensembl databases were detected via a pooling and sequencing strategy. A 15 bp insertion (rs665862918) in the first intron of HIAT1 was selected and classified on an electrophoresis platform in the Shaanbei white cashmere goat (SBWC) population. The correlation analysis revealed that rs665862918 is significantly highly associated with chest width (p = 1.57 × 10−5), chest depth (p = 8.85 × 10−5), heart girth (p = 1.05 × 10−7), body length (p = 0.022), and height at hip cross (p = 0.023) in the SBWC population (n = 1013). Further analysis revealed that individuals with a genotype insertion/insertion (II) of the rs665862918 locus exhibited better growth trait performance than individuals with an insertion/deletion (ID) or deletion/deletion (DD). These findings verify that HIAT1 affects the body size of goats and that rs665862918 could be a potential molecular marker for growth traits in goat breeding.

show abstract

Section: Discussionmentioning

confidence: 58%

Detection of rs665862918 (15-bp Indel) of the HIAT1 Gene and its Strong Genetic Effects on Growth Traits in Goats

Gao

Song

et al. 2020

Animals

Self Cite

View full text Add to dashboard Cite

show abstract

“…The interesting finding was that of association analysis of the combined genotypes showed that individuals in the STH sheep with the AA/AG genotype had larger litter sizes than did those with AA/GG, GA/AG and GG/AA genotypes in the second and third parity. This result may be explained by the fact that this mutation in linkage disequilibrium with other responsible mutations or this mutation may change some events of SYNE2 in term of the post-transcriptional regulation (Oerum et al, 2017;Zhang et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Polymorphism of SYNE2 Gene and its Association with Litter Size in Small Tail Han Sheep

Tian¹,

Wang²,

Tang³

et al. 2021

PJZ

View full text Add to dashboard Cite

show abstract

“…The goat industry, which is one of the most ancient and productive livestock industries, plays an important role in the Chinese economy. However, the current state of goat breeding in China, in particular its low efficiency and the imbalance between demand and supply, has become a major problem requiring immediate attention [13][14][15][16]. In northern Shaanxi, China, Shaanbei white cashmere (SBWC) goats are a crucial breed used for wool and meat, and are cold-tolerant, highly adaptable, and feedstuff-tolerant.…”

Section: Introductionmentioning

confidence: 99%

Detection of a 4 bp Mutation in the 3′UTR Region of Goat Sox9 Gene and Its Effect on the Growth Traits

Wang

et al. 2020

Animals

Self Cite

View full text Add to dashboard Cite

The SRY-type HMG box 9 (Sox9) gene plays an important role in chondrocyte development as well as changes in hypertrophic chondrocytes, indicating that Sox9 can regulate growth in animals. However, no studies to date have examined the correlation between variations in Sox9 and growth traits in goats. Here, we found a 4 bp indel in the 3′UTR of Sox9 and verified its association with growth traits in Shaanbei white cashmere goats (n = 1109). The frequencies of two genotypes (ID and II) were 0.397 and 0.603, respectively, and polymorphic information content (PIC) values showed that the indel had a medium PIC (PIC > 0.25). The 4 bp indel was significantly correlated with body length (p = 0.006), heart girth (p = 0.001), and hip width (p = 4.37 × 10 −4). Notably, individuals with the ID genotype had significantly superior phenotypic traits compared with individuals bearing the II genotype. Hence, we speculated that the 4 bp indel is an important mutation affecting growth traits in goat, and may serve as an effective DNA molecular marker for marker-assisted selection in goat breeding programs.

show abstract

A novel missense mutation (L280V) within POU1F1 gene strongly affects litter size and growth traits in goat

Cited by 25 publications

References 37 publications

Detection of rs665862918 (15-bp Indel) of the HIAT1 Gene and its Strong Genetic Effects on Growth Traits in Goats

Detection of rs665862918 (15-bp Indel) of the HIAT1 Gene and its Strong Genetic Effects on Growth Traits in Goats

Polymorphism of SYNE2 Gene and its Association with Litter Size in Small Tail Han Sheep

Detection of a 4 bp Mutation in the 3′UTR Region of Goat Sox9 Gene and Its Effect on the Growth Traits

Contact Info

Product

Resources

About