A novel model based on disulfidptosis-related genes to predict prognosis and therapy of bladder urothelial carcinoma

Xin, Sixu; Li, Ruixin; Cao, Qi; Wang, Haojie; Wei, Zhihao; Li, Guanyu; Wang, Qin; Zhang, Qi; Chen, YangQuan; Zhang, Chengdong; Zhang, Jianguo

doi:10.1007/s00432-023-05235-7

Cited by 5 publications

(4 citation statements)

References 55 publications

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“…According to these findings, POU5F1 and CTSE could be potential targets for clinical treatment of BCa [ 27 ]. Furthermore, a group of disulfidptosis-related genes (GYS1, LRPPRC, NDUFA11, OXSM, RPN1, SLC3A2, and SLC7A1) are thought to influence the prognosis of bladder urothelial carcinoma (UC) via immune cell infiltration [ 28 ]. Significantly, knocking down TM4SF1 reduces bladder urothelial carcinoma proliferation, revealing the role of disulfidptosis in bladder urothelial carcinoma and sheds light on its potential regulatory mechanisms [ 28 ].…”

Section: Disulfidptosis and Diseasementioning

confidence: 99%

“…Furthermore, a group of disulfidptosis-related genes (GYS1, LRPPRC, NDUFA11, OXSM, RPN1, SLC3A2, and SLC7A1) are thought to influence the prognosis of bladder urothelial carcinoma (UC) via immune cell infiltration [ 28 ]. Significantly, knocking down TM4SF1 reduces bladder urothelial carcinoma proliferation, revealing the role of disulfidptosis in bladder urothelial carcinoma and sheds light on its potential regulatory mechanisms [ 28 ]. The AJAP1 gene encodes a protein that plays an important role in facilitating cell adhesion and migration [ 179 ].…”

Section: Disulfidptosis and Diseasementioning

confidence: 99%

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Disulfidptosis decoded: a journey through cell death mysteries, regulatory networks, disease paradigms and future directions

Chen,

Ma,

Yang

et al. 2024

Biomark Res

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Cell death is an important part of the life cycle, serving as a foundation for both the orderly development and the maintenance of physiological equilibrium within organisms. This process is fundamental, as it eliminates senescent, impaired, or aberrant cells while also promoting tissue regeneration and immunological responses. A novel paradigm of programmed cell death, known as disulfidptosis, has recently emerged in the scientific circle. Disulfidptosis is defined as the accumulation of cystine by cancer cells with high expression of the solute carrier family 7 member 11 (SLC7A11) during glucose starvation. This accumulation causes extensive disulfide linkages between F-actins, resulting in their contraction and subsequent detachment from the cellular membrane, triggering cellular death. The RAC1-WRC axis is involved in this phenomenon. Disulfidptosis sparked growing interest due to its potential applications in a variety of pathologies, particularly oncology, neurodegenerative disorders, and metabolic anomalies. Nonetheless, the complexities of its regulatory pathways remain elusive, and its precise molecular targets have yet to be definitively identified. This manuscript aims to meticulously dissect the historical evolution, molecular underpinnings, regulatory frameworks, and potential implications of disulfidptosis in various disease contexts, illuminating its promise as a groundbreaking therapeutic pathway and target.

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Section: Disulfidptosis and Diseasementioning

confidence: 99%

Section: Disulfidptosis and Diseasementioning

confidence: 99%

Disulfidptosis decoded: a journey through cell death mysteries, regulatory networks, disease paradigms and future directions

Chen,

Ma,

Yang

et al. 2024

Biomark Res

View full text Add to dashboard Cite

show abstract

“…We adopted the same research criteria as in several previous studies. A total of 10 disulfidptosis genes were obtained from the previously published literature: GYS1, NDUFS1, OXSM, LRPRC, NDUFA11, NUBPL, NCKAP1, RPN1, SLC3A2, and SLC7A11 [30][31][32][33]. Subsequently, we performed Pearson correlation analysis of the disulfidptosis genes and lncRNA genes to obtain lncRNAs associated with disulfidptosis in hepatocellular carcinoma using a threshold of |Pearson| ≥ 0.3 and p < 0.…”

Section: Identification Of Lncrnas Associated With Disulfidptosis In Hccmentioning

confidence: 99%

Constructed Risk Prognosis Model Associated with Disulfidptosis lncRNAs in HCC

Jia,

Wang,

Yang

et al. 2023

IJMS

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Disulfidptosis is a novel cell death mode in which the accumulation of disulfide bonds in tumor cells leads to cell disintegration and death. Long-stranded noncoding RNAs (LncRNAs) are aberrantly expressed in hepatocellular carcinoma (HCC) and have been reported to carry significant potential as a biomarker for HCC prognosis. However, lncRNA studies with disulfidptosis in hepatocellular carcinoma have rarely been reported. Therefore, this study aimed to construct a risk prognostic model based on the disulfidptosis-related lncRNA and investigate the mechanisms associated with disulfidptosis in hepatocellular carcinoma. The clinical and transcriptional information of 424 HCC patients was downloaded from The Cancer Genome Atlas (TCGA) and divided into test and validation sets. Furthermore, 1668 lncRNAs associated with disulfidptosis were identified using Pearson correlation. Six lncRNA constructs were finally identified for the risk prognostic model using one-way Cox proportional hazards (COX), multifactorial COX, and lasso regression. Kaplan–Meier (KM) analysis, principal component analysis, receiver operating characteristic curve (ROC), C-index, and column-line plot results confirmed that the constructed model was an independent prognostic factor. Based on the disulfidptosis risk score, risk groups were identified as potential predictors of immune cell infiltration, drug sensitivity, and immunotherapy responsiveness. Finally, we confirmed that phospholipase B domain containing 1 antisense RNA 1 (PLBD1-AS1) and muskelin 1 antisense RNA (MKLN1-AS) were highly expressed in hepatocellular carcinoma and might be potential biomarkers in HCC by KM analysis and quantitative real-time PCR (RT-qPCR). This study demonstrated that lncRNA related to disulfidptosis could serve as a biomarker to predict prognosis and treatment targets for HCC.

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“…Ten disulfidptosis-related genes (NCKAP1, SLC7A11, NUBPL, SLC3A2, RPN1, NDUFA11, GYS1, NDUFS1, OXSM, LRPPRC) were selected based on previous studies (18,27,28). The mRNA and lncRNA expression data and corresponding clinical data of 707 glioma patients were retrieved from the TCGA data portal (https:// portal.gdc.cancer.gov/).…”

Section: Dataset and Sourcementioning

confidence: 99%

Construction and experimental validation of a signature for predicting prognosis and immune infiltration analysis of glioma based on disulfidptosis-related lncRNAs

Guo,

Jiang,

Chen

et al. 2023

Front. Immunol.

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BackgroundsDisulfidptosis, a newly discovered mechanism of programmed cell death, is believed to have a unique role in elucidating cancer progression and guiding cancer therapy strategies. However, no studies have yet explored this mechanism in glioma.MethodsWe downloaded data on glioma patients from online databases to address this gap. Subsequently, we identified disulfidptosis-related genes from published literature and verified the associated lncRNAs.ResultsThrough univariate, multivariate, and least absolute shrinkage and selection operator (LASSO) regression algorithms analyses, we identified 10 lncRNAs. These were then utilized to construct prognostic prediction models, culminating in a risk-scoring signature. Reliability and validity tests demonstrated that the model effectively discerns glioma patients’ prognosis outcomes. We also analyzed the relationship between the risk score and immune characteristics, and identified several drugs that may be effective for high-risk patients. In vitro experiments revealed that LINC02525 could enhances glioma cells’ migration and invasion capacities. Additionally, knocking down LINC02525 was observed to promote glioma cell disulfidptosis.ConclusionThis study delves into disulfidptosis-related lncRNAs in glioma, offering novel insights into glioma therapeutic strategies.

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A novel model based on disulfidptosis-related genes to predict prognosis and therapy of bladder urothelial carcinoma

Cited by 5 publications

References 55 publications

Disulfidptosis decoded: a journey through cell death mysteries, regulatory networks, disease paradigms and future directions

Disulfidptosis decoded: a journey through cell death mysteries, regulatory networks, disease paradigms and future directions

Constructed Risk Prognosis Model Associated with Disulfidptosis lncRNAs in HCC

Construction and experimental validation of a signature for predicting prognosis and immune infiltration analysis of glioma based on disulfidptosis-related lncRNAs

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