A Novel Multifunctional Compound Camellikaempferoside B Decreases Aβ Production, Interferes with Aβ Aggregation, and Prohibits Aβ-Mediated Neurotoxicity and Neuroinflammation

Yang, Sherry; Liu, Wen; Lü, Shan; Tian, Yongzhen; Wang, Weiyun; Ling, Tie-Jun; Liu, Rui‐tian

doi:10.1021/acschemneuro.6b00091

Cited by 31 publications

(16 citation statements)

References 52 publications

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“…The TOF-MS/MS spectra of both the compounds showed the loss of A-ring of the flavanolic unit (−126 Da), whereas the loss of the [gallic acid-H 2 O] moiety provided the fragment ion at m/z 305.0673(78). The presence of gallic acid was further confirmed by the fragment ion at m/z 169.0146 (51), which was for compound 15 the base peak of the TOF-MS/MS spectrum ( Figure S4A; [35,37]). A similar fragmentation pathway characterized compound 26, which was tentatively identified as epicatechin gallate, whose TOF-MS/MS spectrum also showed the gallate ion as base peak ( Figure S4B).…”

Section: Chemical Composition Of Alcoholic Extracts From Commercializmentioning

confidence: 78%

“…Acyl flavonoid glycosides were identified as active ingredients with good Kaempferol coumaroyl glycosides, such as camellikaempferoside B, were reported as a constituent of Fuzhuan brick tea, which is a kind of uniquely microbial fermented tea in China [50]. This compound was found to possess the properties of both kaempferol and p-coumaric acid and significantly inhibit Aβ production by decreasing β-secretase activity [51]. Their biosynthesis is mediated by an acyltransferase, namely CsHCT, that can catalyze the transfer of an acyl group to the donor substrate [52].…”

Section: Chemical Composition Of Alcoholic Extracts From Commercializmentioning

confidence: 99%

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Coumaroyl Flavonol Glycosides and More in Marketed Green Teas: An Intrinsic Value beyond Much-Lauded Catechins

et al. 2020

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Marketed green teas (GTs) can highly vary in their chemical composition, due to different origins, processing methods, and a lack of standardization of GT-based products. Consequently, biological activities become difficult to correlate to the presence/content of certain constituents. Herein, ultra-high-performance liquid chromatography (UHPLC) combined with high-resolution tandem mass spectrometry (HR MS/MS) was successfully applied to six commercial GT products, extracted by ethanol sonication, to disclose their polyphenol profile beyond the well-known catechins. The relative abundance of each class of metabolites was correlated to antiradical and antilipoperoxidant data through hierarchical clustering analysis, since it reasonably affects the beneficial properties of the product that reaches the consumer. The thiobarbituric acid reactive substances (TBARS) assay demonstrated that GT extracts effectively counteracted the UV-induced lipoperoxidation of hemp oil, which is highly rich in Polyunsaturated Fatty Acids (PUFAs), and therefore highly unstable. The Relative Antioxidant Capacity Index (RACI) comprehensively emphasized that gunpower and blend in filter GTs appeared to be the less active matrices, and except for a GT-based supplement, the Sencha GT, which was particularly rich in flavonol glycosides, was the most active, followed by Bancha GT.

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Section: Chemical Composition Of Alcoholic Extracts From Commercializmentioning

confidence: 78%

Section: Chemical Composition Of Alcoholic Extracts From Commercializmentioning

confidence: 99%

Coumaroyl Flavonol Glycosides and More in Marketed Green Teas: An Intrinsic Value beyond Much-Lauded Catechins

et al. 2020

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“…Inhibition of Aβ aggregation may simultaneously alter the conformation of Aβ and reduce Aβ oligomer‐induced cytotoxicity . Our results showed that AOEP2 inhibited Aβ aggregation but did not decrease the oligomer formation.…”

Section: Discussionmentioning

confidence: 62%

A mimotope of Aβ oligomers may also behave as a β‐sheet inhibitor

et al. 2017

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Beta-amyloid (Aβ) oligomers are strongly associated with the cascade of harmful events leading to neurodegeneration in Alzheimer's disease (AD). Elimination of Aβ oligomers or inhibition of Aβ assembly is a valuable therapeutic approach for the treatment of AD. Here, we obtained a mimotope of Aβ oligomers, AOEP2, by screening a peptide library using oligomer-specific antibodies. The antibodies induced by AOEP2 specifically recognize Aβ oligomers rather than monomers and fibrils. Interestingly, the AOEP2 peptide binds to Aβ monomers and inhibits the formation of Aβ oligomers and β-sheet structure, reduces Aβ42-induced neurotoxicity, and decreases the release of proinflammatory cytokines. Taken together, AOEP2, a novel multifunctional peptide directly or indirectly targeting Aβ, has promising therapeutic potential for AD.

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“…Compelling evidence has demonstrated that Ab produces toxicity in neurons (73,74) and in glial cells (75,76). These observations have been corroborated in mice and rats (77,78), especially Tg2576 mice, which are a canonical AD experimental model.…”

Section: Signaling Pathways Involved In Mediating the Effects Of Cox-mentioning

confidence: 88%

Integrated communications between cyclooxygenase‐2 and Alzheimer's disease

Guan

Wang

2018

The FASEB Journal

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Elevated levels of cyclooxygenase-2 (COX-2) and prostaglandins (PGs) are involved in the pathogenesis of Alzheimer's disease (AD), which is characterized by the accumulation of β-amyloid protein (Aβ) and tau hyperphosphorylation. However, the gaps in our knowledge of the roles of COX-2 and PGs in AD have not been filled. Here, we summarized the literature showing that COX-2 dysregulation obviously influences abnormal cleavage of β-amyloid precursor protein, aggregation and deposition of Aβ in β-amyloid plaques and the inclusion of phosphorylated tau in neurofibrillary tangles. Neuroinflammation, oxidative stress, synaptic plasticity, neurotoxicity, autophagy, and apoptosis have been assessed to elucidate the mechanisms of COX-2 regulation of AD. Notably, an imbalance of these factors ultimately produces cognitive decline. The current review substantiates our understanding of the mechanisms of COX-2-induced AD and establishes foundations for the design of feasible therapeutic strategies to treat AD.-Guan, P.-P. and Wang, P. Integrated communications between cyclooxygenase-2 and Alzheimer's disease.

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A Novel Multifunctional Compound Camellikaempferoside B Decreases Aβ Production, Interferes with Aβ Aggregation, and Prohibits Aβ-Mediated Neurotoxicity and Neuroinflammation

Cited by 31 publications

References 52 publications

Coumaroyl Flavonol Glycosides and More in Marketed Green Teas: An Intrinsic Value beyond Much-Lauded Catechins

Coumaroyl Flavonol Glycosides and More in Marketed Green Teas: An Intrinsic Value beyond Much-Lauded Catechins

A mimotope of Aβ oligomers may also behave as a β‐sheet inhibitor

Integrated communications between cyclooxygenase‐2 and Alzheimer's disease

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