A novel multifunctional nano-platform with enhanced anti-cancer and photoacoustic imaging modalities using gold-nanorod-filled silica nanobeads

Chen, Po Jung; Hu, Shang‐Hsiu; Fan, Chih Tai; Li, Meng Lin; Chen, San‐Yuan; LIu, Dean-Mo

doi:10.1039/c2cc37702k

Cited by 41 publications

(26 citation statements)

References 19 publications

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“…In addition, AuNPs can attain high photothermal conversion effect upon laser illumination and are highly biocompatible, have good chemical inertness, excellent physiochemical properties, and a high extinction coefficient . AuNPs have been synthesized as nanorods, nanoprisms, nanocages, nanospheres, nanostars, nanodisks, bipyramids and rhombic dodecahedra, nanoplates, nanoshells, nanotripods, and nanowreaths …”

Section: Inorganic Contrast Agentsmentioning

confidence: 99%

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

et al. 2018

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Photoacoustic (PA) imaging as a fast‐developing imaging technique has great potential in biomedical and clinical applications. It is a noninvasive imaging modality that depends on the light‐absorption coefficient of the imaged tissue and the injected PA‐imaging contrast agents. Furthermore, PA imaging provides superb contrast, super spatial resolution, and high penetrability and sensitivity to tissue functional characteristics by detecting the acoustic wave to construct PA images. In recent years, a series of PA‐imaging contrast agents are developed to improve the PA‐imaging performance in biomedical applications. Here, recent progress of PA contrast agents and their biomedical applications are outlined. PA contrast agents are classified according to their components and function, and gold nanocrystals, gold‐nanocrystal assembly, transition‐metal chalcogenides/MXene‐based nanomaterials, carbon‐based nanomaterials, other inorganic imaging agents, small organic molecules, semiconducting polymer nanoparticles, and nonlinear PA‐imaging contrast agents are discussed. The applications of PA contrast agents as biosensors (in the sensing of metal ions, pH, enzymes, temperature, hypoxia, reactive oxygen species, and reactive nitrogen species) and in bioimaging (lymph nodes, vasculature, tumors, and brain tissue) are discussed in detail. Finally, an outlook on the future research and investigation of PA‐imaging contrast agents and their significance in biomedical research is presented.

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Section: Inorganic Contrast Agentsmentioning

confidence: 99%

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

et al. 2018

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“…EDTA attached to the Au NR surfaces through electrostatic interactions with the stabilizer CTAB. With the addition of ethanol, which is a nonsolvent for both PSa and EDTA, counterion condensation of cationic PSa-NH 2 and anionic EDTA occurred around the Au NRs as the nucleation center 35,37 . After the formation of Schiff base bonds between the amino groups of PSa-NH 2 and the aldehyde groups of GA, EDTA was removed through centrifugation, and Au NRs were encapsulated in the PSa-NH 2 matrix to form Au@PSa nanocomposites.…”

Section: Resultsmentioning

confidence: 99%

“…Taking the enhanced photothermal effects from the large amount of unlocked Au NRs into account, the PTT performance of the Au@PSa nanocomposites is worth examination. Compared with the previous work in which more than one Au NR was encapsulated in mesoporous silica nanobeads 37 , diverse natural PSa provide not only a responsive self-destructible matrix but also inherent targeting properties, which could enhance the therapeutic effects while minimizing side effects. The responsive self-destruction and high-performance PTT of the Au@PSa nanocomposites were investigated in detail.…”

Section: Introductionmentioning

confidence: 96%

Self-destructible polysaccharide nanocomposites with unlockable Au nanorods for high-performance photothermal therapy

et al. 2018

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Multifunctional organic/inorganic nanocomposites are highly attractive for effective biomedical applications. In this work, versatile types of self-destructible polysaccharide (dextran or pullulan) nanocomposites (denoted Au@PSa) with adjustable amounts of unlockable Au nanorods (Au NRs) were fabricated as highly efficient photothermal cancer therapy systems. Taking advantage of the acidic endosomes and high concentration of glutathione (GSH) present in cancer cells, the responsive self-destruction of Au@PSa nanocomposites could unlock the abundant encapsulated Au NRs within cells. Notably, the pullulan-based nanocomposites (denoted Au@Pul) demonstrated liver cell-targeting properties, which could enhance the therapeutic effects while minimizing side effects. The strong absorption of the unlocked Au NRs in the near-infrared region was utilized to examine the photothermal performance. The Au@PSa nanocomposites with a moderate amount of Au NRs in the matrix exhibited very impressive photothermal effects in tumor therapy, where the encapsulated Au NRs were unlocked in the tumor region to realize the observed high performance. The proposed system could be further extended, as the polysaccharides were functionalized with amino groups. The current work provides a facile strategy to construct flexible therapeutic platforms with responsive selfdestruction features.

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“…280 The Plasmon resonance absorption and scattering of AuRNBs in the NIR region makes them attractive for many in vivo imaging applications. 281 282 Significantly high photothermal stability and tunable heating capability can be reached by the nanoprobes with its multifunctional capabilities, which also offers potential advantages for anticancer purposes and PA imaging. 283 284 Recently, the sentinel lymph-node (SLN) mapping methods with the help of blue dye or nanometer-sized radioactive colloid injections have become intraoperative, because of the need for visual detection.…”

Section: Photoacoustic Imagingmentioning

confidence: 99%

Nanoparticles for Molecular Imaging

Yang¹,

Liao²,

Thakor³

et al. 2014

j biomed nanotechnol

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Imaging techniques have been instrumental in the visualization of fundamental biological processes, identification and diagnosis of diseased states and the development of structure-function relationships at the cellular, tissue and anatomical levels. Together with the advancements made in imaging techniques, complementary chemical compounds, also known as imaging probes or contrast agents, are developed to improve the visibility of the image by enhancing sensitivity, and for the identification and quantitation of specific molecular species or structures. Extensive studies have been conducted to explore the use of inorganic nanoparticles which exhibit magnetic and optical properties unique to the nano regime so as to enhance the signals sensitivity for magnetic resonance and fluorescent imaging. These physical properties are tailored by controlling the size, shape and surface properties of nanoparticles. In addition, surface modification of nanoparticles is often required to improve its stability, compatibility and functionality. Surfactants, surface-active agents, have been used to engineer the surface characteristics of nanoparticles to improved particle stability and functionality. Surfactants enhance nanoparticle stability through the reduction of surface energy, and by acting as a barrier to agglomeration through either steric hindrance or repulsive electrostatic forces. Coupling of nanoparticles with biomolecules such as antibodies or tumor targeting peptides are enabled by the presence of functional groups (e.g., carboxyl or amine groups) on surfactants. This paper provides an overview of the chemistry underlying the synthesis and surface modification of nanomaterials together with a discussion on how the physical properties (e.g., magnetic, absorption and luminescent) can be controlled. The applications of these nanoparticles for magnetic resonance, fluorescent and photoacoustic imaging techniques that do not rely on ionizing radiation are also covered in this review.

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A novel multifunctional nano-platform with enhanced anti-cancer and photoacoustic imaging modalities using gold-nanorod-filled silica nanobeads

Cited by 41 publications

References 19 publications

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications

Self-destructible polysaccharide nanocomposites with unlockable Au nanorods for high-performance photothermal therapy

Nanoparticles for Molecular Imaging

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